Qing Wang

Dysregulation of transcription networks regulating oligodendrogenesis in age-related decline in CNS remyelination

The paper identifies age-related dysregulation of transcription networks in oligodendrocyte differentiation using single-nucleus RNA and ATAC sequencing in mice, with parallels in MS lesions.

Transcriptional dynamics of the oligodendrocyte lineageand its regulation by the brain erythropoietin system

This study investigates how erythropoietin (EPO) and its receptor (EPOR) regulate oligodendrocyte lineage dynamics in the adult mouse hippocampus, showing EPO promotes differentiation and maturation, and suggests potential therapeutic applications for remyelination.

Erythropoietin restrains the inhibitory potential of interneurons in the mouse hippocampus

This study shows that erythropoietin (EPO) reduces inhibitory potential in hippocampal interneurons, enhancing pyramidal neuron excitability and potentially improving neuropsychiatric symptoms.

Radiogenomics of C9orf72 expansion carriers reveals global transposable element de-repression and enables prediction of thalamic atrophy and clinical impairment

The paper investigates C9orf72 expansion carriers using radiogenomics to link peripheral blood transcriptomics with thalamic atrophy and clinical impairment, finding global transposable element de-repression and associations between C9orf72 expression and disease severity.

ROCK1/Drp1-mediated aberrant mitochondrial fission is crucial for dopaminergic nerve cell apoptosis

This study identifies ROCK1-regulated mitochondrial fission as a key mechanism in dopaminergic nerve cell apoptosis in Parkinson's disease.