Robert Perneczky

Automated quantification of white matter hyperintensity confluence: A measure of spatial organisation beyond volume and visual rating scales

This paper introduces an automated method to quantify white matter hyperintensity confluence, showing it correlates with cognitive performance and dementia subtypes beyond volume.

Unveiling the Power of High-Dimensional Cytometry Data with cyCONDOR

The paper introduces cyCONDOR, a computational framework for high-dimensional cytometry data analysis, offering scalable and user-friendly tools for preprocessing, clustering, and downstream biological interpretation.

SMAS: Structural MRI-Based AD Score using Bayesian VAE

This paper introduces SMAS, a Bayesian VAE-based AD score from structural MRI data, showing strong correlations with cognitive decline and brain atrophy markers, and outperforming existing measures in predicting AD.

Fornix fractional anisotropy mediates the association between Mediterranean diet adherence and memory four years later in older adults without dementia

The paper examines if fractional anisotropy of the fornix mediates the link between Mediterranean diet adherence and verbal memory decline in older adults over four years.

Lifelong musical activity is associated with multi-domain cognitive and brain benefits in older adults

This study finds that lifelong musical activity is linked to better cognitive abilities and preserved brain structure in older adults, suggesting it may enhance cognitive resilience.

Individualized Gaussian Process-based Prediction of Memory Performance and Biomarker Status in Ageing and Alzheimer's disease

The paper uses Gaussian process multikernel modeling to predict memory performance and CSF biomarkers in ageing and Alzheimer's disease using MRI and other data.

Meta-analyses identify differentially expressed microRNAs in Parkinson’s disease

This paper identifies differentially expressed microRNAs in Parkinson’s disease through meta-analyses of multiple datasets, finding significant associations in brain and blood samples.

Differential expression of microRNAs in Alzheimer’s disease brain, blood and cerebrospinal fluid: a systematic review and meta-analysis

This study identifies differentially expressed microRNAs in Alzheimer’s disease across brain, blood, and cerebrospinal fluid through a systematic review and meta-analysis of 147 datasets.

CXCR4 involvement in neurodegenerative diseases

The paper identifies a genetic variant near CXCR4 associated with increased risk for PSP and PD, showing dysregulation of CXCR4 and microglia-related genes in neurodegenerative diseases.

Immune-related genetic enrichment in frontotemporal dementia

This study identifies genetic overlaps between frontotemporal dementia and immune-mediated diseases, finding strong enrichment with rheumatoid arthritis and moderate enrichment with other immune conditions.