Jennifer A. Juno

Live attenuated YFV-17D vaccine induces robust B and T cell immunity in vaccine-draining lymph nodes

This study examines immune dynamics in lymph nodes after YFV-17D vaccination, identifying robust B and T cell responses and a conserved germinal center program across different vaccines.

Pre-existing systemic and nasal antibodies against avian H5 influenza A viruses vary according to childhood imprinting

The paper examines pre-existing antibodies against avian H5 influenza A viruses in individuals born between 1928-1999, showing variations based on childhood exposure and birth year.

High-dimensional multiomics reveals perturbations to IL-6/IL-6R axis and RUNX3 in CD4+ T cells during third trimester pregnancy

This study identifies changes in CD4+ T cell surface proteins and transcriptomes during pregnancy, highlighting perturbations in the IL-6/IL-6R axis and RUNX3 expression.

A novel chimeric coronavirus spike vaccine combining SARS-CoV-2 RBD and scaffold domains from HKU-1 elicits potent neutralising antibody responses

A chimeric coronavirus spike vaccine combining SARS-CoV-2 RBD and HKU-1 scaffold domains elicits potent neutralising antibodies and CD4 T cell help in mice and macaques.

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity

The paper identifies transcriptional modules and cytokine signaling pathways that drive functional heterogeneity in T follicular helper cells across different infections.

Immunodominance is a poor predictor of vaccine-induced T follicular helper cell quality

The paper investigates the relationship between CD4 T cell epitope immunodominance and vaccine-induced T follicular helper cell quality, finding that immunodominance is not predictive of helper quality.

Memory T and B cells with recognition of avian influenza hemagglutinins are poorly responsive to existing seasonal influenza vaccines

The paper quantifies pre-existing human B cell responses to avian influenza H5 and H7 hemagglutinins and shows limited boosting by seasonal vaccines.

Deconvoluting TCR-dependent & -independent activation is vital for reliable Ag-specific CD4+ T cell characterization by AIM assay

The paper shows that AIM assays overestimate Ag-specific CD4+ T cells due to TCR-independent activation and introduces a modified assay using CXCR4-CD137+ cells for accurate characterization.

Transiently boosting Vγ9+Vδ2+ γδ T cells early in Mtb coinfection of SIV-infected juvenile macaques does not improve Mtb host resistance.