Shuwen Zhang

Immunopipe: A comprehensive and flexible scRNA-seq and scTCR-seq data analysis pipeline

Immunopipe provides a flexible pipeline for integrated analysis of scRNA-seq and scTCR-seq data to enhance understanding of T-cell immunity and immunotherapy.

Single-cell multiomics reveals disrupted glial gene regulatory programs in Alzheimer's disease via interpretable machine learning

This study uses single-cell multi-omics data to identify disrupted glial gene regulatory programs in Alzheimer's disease using interpretable machine learning.

Salt-dependent non-catalytic allostery of human USP14-regulated 26S proteasome

This study uses cryo-EM and genetic engineering to show how USP14 non-catalytically regulates proteasome activity through salt-dependent allosteric changes.

Rod-shaped microglia interact with neuronal dendrites to regulate cortical excitability in TDP-43 related neurodegeneration

The paper identifies rod-shaped microglia in a TDP-43 mouse model that interact with neuronal dendrites to reduce cortical hyperexcitability and protect against neurodegeneration.