experimental assay

Structural determinants underlie the essentiality of the m-type thioredoxin TrxA in Synechocystis

The paper identifies structural determinants in TrxA that confer its essentiality in Synechocystis, showing that its function cannot be replaced by other thioredoxins despite similar abundance.

Age-associated repression of HNF4α is a driver and potential therapeutic target in liver metabolic dysfunction

This study identifies age-associated repression of HNF4α as a driver of liver metabolic dysfunction and shows that restoring HNF4α can reverse some age-related liver defects.

Tfcp2l1 recruits Thrap3 to sustain ESC self-renewal via Jmjd1c exon-5 splicing and DNA repair choice

This study identifies Tfcp2l1 and Thrap3 as regulators of ESC self-renewal through exon-5 splicing of Jmjd1c and DNA repair pathway choice.

Pathogenic MYRF ICA Domain Variant is Aberrantly Trafficked in the RPE and Results in Isolated Nanophthalmos

This study identifies a pathogenic MYRF variant causing isolated nanophthalmos by showing it is cleavage deficient, mislocalized, and reduces transcriptional activity with SOX10.

Stress-adapted endophytic Pseudomonas strains isolated from unmanaged lupin promote potato growth and suppress verticillium wilt through complementary biocontrol and plant growth-promoting mechanisms

Core MCC of Arabidopsis thaliana: structural dissection provides new insights into Mad2, BubR1 and CDC20

The paper identifies protein-protein interactions in the core MCC of Arabidopsis thaliana using structural analysis, revealing new binding sites and interaction hierarchies.

The ants (Hymenoptera: Formicidae) of Iceland

The paper compiles ant records from Iceland, identifies species origins, and highlights potential ecological impacts of invasive ants.

Automatic orofacial behaviors remap within cortical substrates for voluntary motor control in freely moving primates

This study identifies cortical substrates involved in modulating automatic orofacial behaviors in macaques, showing distinct neural dynamics for voluntary and automatic actions.

Signals beneath the ectoderm: Mesodermal FGF signaling keeps the dorsally closing epithelium in shape

The paper shows that mesodermal FGF signaling stabilizes the ectoderm during dorsal closure in Drosophila, revealing a reciprocal influence between mesoderm and ectoderm.

First-in-class -PET radiotracers for GPR39: A platform for noninvasive target engagement imaging in vivo

This paper introduces [18F]GPR39 2.1, a PET radiotracer for noninvasive imaging of GPR39, showing high specificity and sensitivity in vivo.

BCAS3 regulates WIPI2b via a direct interaction in the ATG16L1-binding cleft

The paper identifies BCAS3 as a novel interactor of WIPI2b that regulates its membrane association through interaction with PtdIns3P.

Polyphosphate metabolism genes are associated with hydroxyapatite biomineralization capacity in a novel hydrogenotrophic methanogen Methanobacterium AMB_03

This study links polyphosphate metabolism genes to hydroxyapatite biomineralization in Methanobacterium AMB_03, showing that polyphosphate synthesis enables carbonate-substituted hydroxyapatite precipitation under phosphate-enriched conditions.

Impaired Fermentation in the Absence of Gut Microbiota Promotes Inulin-Induced Intestinal Inflammation

The paper shows that impaired gut microbiota fermentation of inulin leads to intestinal inflammation in mice, highlighting the importance of microbial metabolism in fiber tolerance.

MmuPV1 and HPV E6 Elevate Nuclear Accumulation of IKK? to Impair NF-κB Signaling to Promote Persistent Infection

This study shows MmuPV1 and HPV16 E6 oncoproteins disrupt NF-κB signaling by increasing nuclear IKKα localization, suggesting a shared mechanism in papillomavirus persistence.

Phosphorylation-dependent conformational change in the Keratin 19 head domain: Implications for filament assembly and binding to GSK3β and 14-3-3

This study identifies a phosphorylation-dependent conformational change in the K19 head domain that affects filament assembly and interactions with GSK3β, but not 14-3-3 proteins.

Variable errors suppress implicit motor adaptation among older adults

This study shows that older adults exhibit enhanced implicit motor adaptation only with consistent errors, not variable ones, suggesting error consistency is key for age-related adaptation.

Rapid generation of marsupial induced pluripotent stem cells suitable for use in next-generation conservation

This study generates transgene-free iPSCs from the fat-tailed dunnart, demonstrating their pluripotency and potential for use in conservation biotechnology.

Intracellular bio-synthesizing Gold Nanoparticles using bacterial systems and their applications in photothermal therapy (A green approach)

This paper develops a bio-hybrid platform using Escherichia coli to synthesize gold nanoparticles for photothermal therapy, showing enhanced thermal response and biocompatibility.

Novel Tau Interaction Partners as Potential Biomarkers and Therapeutic Targets in Neurodegenerative Diseases

This study identifies 15 novel tau-interacting proteins through yeast two-hybrid screening and validates their interactions, revealing potential biomarkers and therapeutic targets for neurodegenerative diseases.

A Standalone PD-1 Chimeric Switch Receptor T-Cell Platform Expands the Therapeutic Window of PD-L1 Targeting in Solid Tumors

This paper develops a PD-1 chimeric switch receptor T-cell platform that improves tumor targeting while reducing toxicity to normal cells in PD-L1-targeted therapies.

The Src family kinases Lck and Fyn promote transendothelial migration of T cells

This study identifies Lck and Fyn as essential Src family kinases required for T cell transendothelial migration through their regulation of PI3K signaling and cytoskeletal dynamics.

Structural evolution of Fcα/μR-mediated antibody recognition

This study characterizes the structural evolution of Fcα/μR-mediated antibody recognition across vertebrates by analyzing duck and mouse Fc/R interactions with IgM and IgA.

The role of familiarity in grouping decisions of Trinidadian guppies

This study investigates whether Trinidadian guppies prefer to group with familiar individuals, finding no evidence for familiarity preference despite a strong preference for conspecifics.

Enhanced hypoxic ventilatory response is accompanied by a decrease in carotid body mitochondrial oxygen affinity in heart failure

This study investigates changes in carotid body mitochondrial function in heart failure, finding decreased oxygen affinity and increased oxidative stress.

Diverse bacteria exhibit superadditive growth on mixed classes of carbon sources

The paper shows that some bacteria grow better on mixed carbon sources than on individual ones, and links this to their genetic makeup and metabolic preferences.

Interventional breath analysis reveals oral microbial conversion of 1,2-Propanediol into Propanal and 1-Propanol

This study shows that oral exposure to 1,2-propanediol increases exhaled propanal and 1-propanol, suggesting microbial conversion in the mouth.

ATF3 Preserves Macrophage Cholesterol Homeostasis during Metabolic Stress

This study shows ATF3 helps macrophages manage cholesterol during metabolic stress by balancing inflammation and sterol-responsive gene expression.

SEC16A/MAG5-mediated ER export shapes ABA receptor homeostasis

The paper identifies SEC16A/MAG5 as essential for ABA receptor homeostasis by mediating ER export and trafficking, impacting ABA signaling without affecting ABA levels.

Cell cycle progression and stalked cell morphogenesis in Caulobacter crescentus are regulated independently by the flagellum

This study identifies fss genes that regulate stalked cell morphogenesis and cell cycle progression independently of the flagellum in Caulobacter crescentus.

sPLA2 inhibitor-loaded nanoparticles mitigate spontaneous osteoarthritis in guinea pigs

This study shows that sPLA2 inhibitor-loaded nanoparticles reduce spontaneous osteoarthritis in guinea pigs by decreasing cartilage damage and inflammation.