metabolism & bioenergetics

This study investigates how phosphate and acidosis affect contractile mechanics in skeletal muscle fibers at 37°C in older adults, finding fiber-type specific changes under fatigue conditions.

This study investigates how heating affects organic matter bioavailability in marine sediments, finding that heating does not significantly alter bulk OM bioavailability but mobilizes older material.

This study uses FluidFM and FLIM to analyze how A-type and B-type lamins and microtubules respond to mechanical and chemical cues, revealing distinct roles in nuclear elasticity and viscous response.

This study investigates how RNA virus infection reprograms the metabolism of a marine diatom, revealing significant changes in lipid and nitrogen pathways and stress responses.

The paper shows how cytokinin receptor specificity and metabolic stability determine isoform-specific signaling and senescence delay in Arabidopsis.

The paper identifies PatA, GabT, and IlvE as transaminases involved in CML and CM-Cad metabolism in E. coli, revealing a branched pathway and novel metabolites.

The paper investigates Rpl40 paralogs in yeast, showing they differentially affect mitochondrial proteome and lipid homeostasis under stress.

The paper describes a protocol for producing 13C-labelled yeast extract as an internal standard for metabolomics and quantifying intracellular metabolites.

This study shows that plants redirect sugar transport to fuel tissue repair after wounding by converting sucrose to glucose in the cell wall and importing it into adjacent cells.

This paper models the Warburg effect's role in the tumor microenvironment, showing lactate secretion creates a growth-exclusion tradeoff resolved by pro-tumor stromal cross-feeding.

This study shows microtubule association regulates mitochondrial morphology and function, with polymerization driving hyperfusion during starvation.

This study shows CD300e deficiency worsens obesity-related metabolic dysfunction in mice and human cells, highlighting its role in adipose tissue macrophage metabolism and potential as a therapeutic target.

This study measures metabolic heat output of individual Drosophila brains to examine effects of sex, genotype, age, and disease on brain metabolism.

This study proposes a physical model of the nucleus that explains its mechanical behavior under deformation, highlighting the role of the envelope and chromatin in nuclear mechanics.

The paper shows that the enzyme SpeC in enterobacteria degrades Nε-modified lysine derivatives, producing biogenic amines and enabling microbial utilization of these compounds as nitrogen sources.

This study shows that mosquito larvae rely on gut microbiota for energy production, nitrogen excretion, and sterol metabolism, with bacterial vitamins and fatty acid degradation playing critical roles in larval development.

This study examines phenotypic plasticity in woodland strawberry genotypes across a latitudinal gradient, finding that plasticity varies by trait and is influenced by long-term temperature rather than precipitation.

This study shows circadian disruption affects hepatic lipid profiles, mitochondrial function, and calcium signaling via DHEA-GPR110 pathway in hepatocytes.

This study shows that acetyl-CoA inhibits PDEs in Pseudomonas aeruginosa, linking cell envelope biosynthesis to c-di-GMP signaling and biofilm formation.

This paper shows dietary fructose promotes MASH/HCC by enhancing intestinal HIF-2α-dependent iron absorption through the KHK/PKM2/HIF-2 axis.

This study uses quantitative proteomics to show that RVE4, 6, and 8 regulate proteome-level responses to osmotic and salt stress in Arabidopsis, particularly at end-of-day.

This study investigates how exercise affects insulin sensitivity and FAHFA levels in obese mice, finding that chronic exercise improves insulin sensitivity in wild-type mice but not in ADTRP KO mice.

This study shows that estrogen deficiency worsens diastolic dysfunction and energy metabolism in hypertensive female mice, with improvements seen when estrogen or its receptor agonists are administered.

The paper investigates how type I IFN reprograms CD4⁺ T cell lipid metabolism during acute HIV/SIV infection and identifies metabolic changes linked to viral reservoir establishment.

This study shows that lipid-rich waste oils reshape the gut microbiome and biomass composition of black soldier fly larvae during bioconversion, with different oils affecting growth and fatty-acid profiles differently.

The paper identifies a mitochondrial degradation pathway for metallothionein that releases zinc during zinc limitation, maintaining metabolic homeostasis.

This study identifies PIEZO1-VEGFR2 interaction as a mechanotransduction axis regulating CD34+ cell differentiation and endothelial repair in arteriovenous fistulas through the AKT-FoxO1 pathway.

This study identifies BilR and BilV as enzymes involved in the branched microbial metabolism of bilirubin to urobilinogen in the human gut.