metabolism & bioenergetics

This study identifies Contact-phagy as a selective autophagy pathway that targets ER-mitochondria contact sites for turnover under metabolic and mitochondrial stress.

The paper introduces scTPPM, a single-cell multi-omics approach that co-profiles transcriptomes, proteomes, eight PTMs, and metabolomes, revealing dynamic crosstalk during mouse oocyte meiosis.

This study identifies ASP as a modulator of host cell homeostasis through proteomics and functional validation, revealing its role in DNA repair and mitochondrial function.

This paper uniformly re-analyzes public omics data from exercise studies in humans and rodents, providing standardized effect sizes and meta-analyses across multiple tissues and molecular layers.

This study examines proteomic changes in Geodermatophilus obscurus G20 under UV stress, showing distinct responses in acute and recovery phases.

The paper identifies oleate depletion as a metabolic signal sensed by C. elegans to activate innate immunity against bacterial infection.

The paper shows that CO2-concentrating nanoparticles modify photosynthesis and cell wall structure in Arabidopsis cells over time.

This study develops an LRH-1 agonist that improves insulin sensitivity and reduces liver fat in obese mice, revealing peroxisomal lipid metabolism as a key pathway.

This study investigates proteome changes in multiple organs of mice with Anorexia Nervosa using a gut microbiota-depleted model, identifying microbiota-dependent and -independent protein alterations.

The paper presents a multimodal dataset from a 40-hour forced-desynchrony protocol to study circadian rhythms and their effects on physiology, ocular function, and behavior.

The paper shows that fatty acid desaturation, specifically DGLA, influences cellular decisions between ferroptosis and senescence, with implications for aging and obesity.

This study shows that vertical sleeve gastrectomy reduces 11βHSD1 and IL6 in mice and humans, linking glucocorticoid metabolism to improved glucose homeostasis and reduced inflammation.

The paper shows that glutaminolysis and mitochondrial metabolism are conditionally crucial for B cell differentiation and cytokine signaling, revealing metabolic regulation of plasma cell generation and cytokine receptor signaling.

This study shows that engineering FAD biosynthesis in E. coli to produce nucleotide analogues increases tolerance to aminoglycoside antibiotics by altering metabolic pathways.

The paper shows that respiration-deficient cells rely on pyruvate carboxylase to prevent asparagine auxotrophy, with effects dependent on mitochondrial heteroplasmy levels.

This study identifies TMEM55B as a regulator of lysosomal acidification and ER-lysosome calcium signaling, which promotes lipolysis and cholesterol metabolism.

This study shows that cytoplasmic recapping of MALAT1 produces the micropeptide MARS, which is regulated by RNA G-quadruplex structures and involved in oxidative stress response.

This study shows that red light exposure reduces SIRT4 in aged mice, enhancing H3K9ac via fatty acid metabolism and mitigating cellular aging.

The paper examines how picocyanobacterial strains from different salinities adapt their growth and metabolism across varying salinity and light conditions.

This study uses a mathematical model to show that circadian clocks in Synechococcus elongatus enhance growth by enabling proteome adjustments that avoid inefficient nighttime growth.

This study shows that endosome motility in Aspergillus species affects light-responsive development and secondary metabolite production.

This study shows that carbon source determines metabolic states in Propionibacterium freudenreichii, affecting redox balance and vitamin B12 biosynthesis.

This study investigates the formation and persistence of a near-clonal green sulfur bacteria bloom using multi-omics approaches, revealing metabolic strategies that support high cell density and environmental stability.

This study compares 2D and 3D suspension cultures of human pluripotent stem cells, finding metabolic rewiring in 3D cultures with increased glycolysis and altered TCA cycle carbon partitioning.

The paper evaluates proteomics platforms for metabolic pathway analysis in biomanufacturing chassis organisms, showing varying proteome coverage across different instruments.

This study identifies the GID/CTLH complex as a regulator of metabolism and innate immunity in macrophages infected with Mycobacterium tuberculosis through ubiquitylation profiling and functional analysis.

This study identifies DeSI1 as a cyclin D-CDK4/6 substrate whose phosphorylation regulates membrane and mitochondrial protein supply during proliferation.

This study identifies AATRhg1 as a tonoplast amino acid transporter involved in soybean resistance to soybean cyst nematodes, with specific amino acid and metabolic changes observed upon its silencing.

This study shows Prochlorococcus forms biofilms, transitions between planktonic and biofilm states, and exudes more organic carbon, suggesting a role in deep-sea carbon export.

This study shows OPN3 promotes lipofuscin accumulation in keratinocytes under blue light and its loss reduces proteomic stress responses and lipofuscin formation.