metabolism & bioenergetics

The paper models magnetic-based biofabrication of spheroids to predict structure and mechanical stress, using experiments and a particle-based simulation.

This paper uses β-galactosidase to convert raffinose oligosaccharides into β-GOS, which are less fermentable by some gut microbes but still usable by beneficial bacteria.

This study shows statin exposure reduces mitochondrial CoQ levels and impairs bioenergetics in astrocytes, but CoQ10 supplementation reverses these effects.

This study maps microbial metabolic phases using online pressure and backscatter measurements in closed batch vials, identifying distinct catabolic and anabolic phases in yeast and syngas fermentation.

This study shows that liver sinusoidal endothelial cells (LSECs) integrate metabolic and immune signals through the MAPK pathway to regulate BMP6 and induce hepcidin, maintaining iron homeostasis during inflammation and stress.

This paper introduces a nanoflow ion-pairing LC-MS method for ultra-low-input polar metabolomics and isotope tracing, showing improved sensitivity and retention for metabolites.

This study shows that phosphate and phosphorylated metabolites, not just compatible solutes, are critical for charge balance and metabolic responses in E. coli during osmotic upshift.

This paper demonstrates that heterologous Pdu BMCs in E. coli can metabolize a broader range of diols and triols than previously known, including glycerol and up to 1,2-pentanediol, and shows their potential for biotechnological applications.

This study shows doxycycline inhibits apicoplast and mitochondrial translation in Plasmodium falciparum and Toxoplasma gondii, reducing protein abundance and mitochondrial complex IV activity.

This study shows N-acetylcysteine's antibacterial activity against S. aureus depends on pH, with neutral pH reducing activity and altering metabolism without inhibiting growth.

The paper identifies ESCRT-dependent plasma membrane remodeling as a mechanism to prevent amino acid toxicity caused by vacuole pH loss in budding yeast.

This study shows that loss of PSAE in Arabidopsis enhances PGR5-dependent cyclic electron transfer and redirects PGRL1 to PSI, while NDH supports CO2 fixation under disrupted PSI conditions.

The paper compares night-time carbohydrate control in grasses and Arabidopsis, finding differences in sucrose and starch turnover rates and suggesting regulatory mechanisms involving Tre6P.

The paper investigates how half-site reactivity in enzymes allows metabolic reactions to redistribute chemical potential, enhancing catalytic efficiency and pathway flexibility.

This paper optimizes and parallelizes the SIFT method to increase throughput and stability, applying it to study single-cell glycolysis and iron homeostasis in Jurkat cells.

The paper introduces ArchaeaHQ, a curated database of 21,644 archaeal genomes with quality control and metadata, to improve representation in computational biology tools.

This study shows that time-restricted feeding extends healthspan in both sexes and lifespan in male mice under normal dietary conditions.

This study quantifies heatwave effects on tree stem water content in a Mediterranean climate, showing species-specific sensitivity and resilience to heat stress.

This study identifies metabolic stress in high-density erythroblast cultures, showing that small molecular weight metabolites limit proliferation and suggesting strategies to improve cell productivity.

MARBL profiles bioenergetic heterogeneity in live cells by noncanonical methionine labeling of the surface proteome, revealing metabolic resilience differences between immune cell types.

This paper introduces molecular community networking to organize metabolite data, revealing hidden connections and discovering novel dipeptide-conjugated bile acids.

The paper investigates how marine diatoms adapt to heat stress through proteomics analysis, finding that high-temperature-tolerant populations use a conservative cellular strategy under thermal stress but fail to adapt under low nitrate conditions.

This study investigates the effects of globin digest and its peptides on skeletal muscle hypertrophy and physical performance in zebrafish, mice, and myoblasts, finding significant improvements in muscle growth and motor function.

This study shows that time-restricted feeding improves glucose intolerance and circadian disruption caused by weight cycling in young obese mice, but not in mid-aged mice.

This study identifies membrane permeability as a key limitation in long-chain alcohol metabolism by P. putida KT2440 through adaptive laboratory evolution and transporter expression.

This study shows that primary cilia in brown fat are essential for ketogenesis and thermogenesis, and their loss causes neonatal lethality in mice.

This study shows that pro- and anti-inflammatory macrophages adjust UCP2 levels based on metabolism and metabolites, with pyruvate and hypoxia playing key roles.