Malaria Research and Control

This paper develops a method to quantify developmental synchrony in malaria parasites that accounts for population dynamics and validates it using simulated data.

This study evaluates the safety, pharmacokinetics, and potential neurological interactions of ivermectin, tafenoquine, and chloroquine in Rhesus macaques, finding no concerning interactions.

This paper identifies MMV1557817 as a dual aminopeptidase inhibitor effective against multiple Plasmodium species and highlights its potential as a multi-target antimalarial drug.

This study evaluates the precision of the Plasmodium knowlesi growth inhibition assay for Plasmodium vivax Duffy-binding protein-based malaria vaccine development, finding significant assay-to-assay variation in %GIA and GIA50.

This study presents a single-cell transcriptome atlas of Plasmodium falciparum sexual development, revealing transcriptional heterogeneity in naturally infected individuals.

This study uses low-coverage whole-genome sequencing to identify adaptation signatures at insecticide resistance loci in Anopheles mosquitoes in southern Ghana.

The paper uses Plasmodium cynomolgi to determine the delayed antimalarial effects of doxycycline and tafenoquine on P. vivax, finding IC50 values for doxycycline and tafenoquine.

The paper models how resource limitation, rather than virulence-transmission tradeoffs, restricts evolution of higher proliferation rates in malaria parasites.

This study shows that the effectiveness of translation inhibitors against Plasmodium berghei liver stages is not determined by their translation inhibition efficacy, as DDD107498, a weak inhibitor, had strong antimalarial effects.

The paper introduces a statistical model to estimate multiplicity of infection and allele frequencies while accounting for incomplete molecular data, finding that it performs better in low-quality data scenarios.

The paper develops fluorescent ATP sensors for Plasmodium falciparum to measure real-time ATP dynamics and identifies drug-class-specific effects on ATP levels.

This study shows that gARID is essential for gametocyte development in Plasmodium by participating in two chromatin remodeling events critical for both male and female gametocytes.

This study shows that malaria mosquitoes prefer plants that are less nutritious and harmful to their survival and reproduction.

The paper models how seasonal importation and genetic drift affect the establishment of drug-resistant Plasmodium falciparum genotypes in high transmission settings.

The paper analyzes P. falciparum genetic diversity and transmission patterns in Ethiopian highlands, finding local transmission and clonal parasite spread.

The paper shows that Plasmodium falciparum invasion of red blood cells does not require basigin's interaction with MCT1, as invasion remains unaffected by disrupting this interaction or removing the basigin transmembrane domain.

This study shows that IL-15 complex treatment increases IL-10 in NK cells, which promotes Tfh differentiation and antibody production against Plasmodium, improving survival from reinfection.

This study shows that older mosquitoes transmit malaria less efficiently but live longer when infected, affecting transmission dynamics.

This study identifies two cryptic species of the Anopheles gambiae complex in Kinshasa, with Anopheles gambiae being the most prevalent.

This study establishes the first laboratory colony of Anopheles coustani, a malaria vector in Madagascar, using forced copulation to enable research on its biology and vector competence.

The paper develops a Bayesian inference method to assess personal and community protection of vector-control interventions using semi-field experimental data.

The paper identifies genetic determinants of multidrug resistance in Plasmodium falciparum and their impact on parasite fitness and drug susceptibility.

This study genetically validates PfFKBP35 as a lethal target in Plasmodium falciparum, showing its role in ribosome homeostasis and revealing non-canonical modes of action for FK506.

MalariaSED predicts chromatin profiles in malaria parasites and identifies noncoding variants linked to invasion and drug resistance.

This paper presents a new high-quality reference genome for South American Plasmodium vivax isolates, showing improved representation compared to existing genomes.

The paper introduces a genomic platform using long-read sequencing to monitor pathogen diversity and identify vaccine antigens in multiclonal infections.

The paper identifies novel proteins in Plasmodium falciparum gametocyte egress vesicles using imaging and BioID, revealing distinct proteomes for osmiophilic bodies and g-exonemes.

The paper identifies epigenetically silenced RNA-binding proteins in malaria hypnozoites and proposes they regulate dormancy and reactivation.

This paper identifies a small molecule inhibitor of Plasmodium falciparum myosin A, showing it blocks ATP hydrolysis and parasite growth.