Malaria Research and Control

AP2-L-Dependent Processes Promote PVM Maintenance and Plasmodium Liver-stage Development

This study shows AP2-L is essential for Plasmodium liver-stage development by regulating PVM formation and host-cell interactions.

Human infection with an ape Plasmodium vivax-like parasite

The paper reports a case of human infection with an ape-like Plasmodium vivax parasite, identified through whole-genome sequencing, suggesting zoonotic transmission from wild gorillas and chimpanzees.

Structural insights and mechanistic inhibition of Plasmodium falciparum dihydroorotate dehydrogenase by newly identified chemotypes

This study identifies new chemotypes that inhibit Plasmodium falciparum dihydroorotate dehydrogenase, revealing structural insights and potential for improved antimalarial drugs.

Genotypic evidence of vector-mediated selection on Plasmodium falciparum in infected field-collected Anopheles mosquitoes

The paper analyzes parasite genotypes in sympatric mosquito species to show divergent selection on Plasmodium falciparum mediated by different vectors.

A PCR-based assay for the sensitive and accurate determination of malaria parasite species that commonly infect humans, including discrimination of Plasmodium ovalecurtisi and Plasmodium ovalewallikeri

The paper introduces a PCR-based assay that accurately distinguishes between Plasmodium ovalecurtisi and Plasmodium ovalewallikeri, with high sensitivity and specificity for malaria diagnosis.

Single-cell characterization of the human immune landscape reveals dysfunction in monocyte-mediated cellular interactions in symptomatic malaria

The paper uses single-cell RNA sequencing to analyze immune cell interactions in asymptomatic and symptomatic malaria patients, finding reduced monocyte-T cell interactions and increased inflammation in symptomatic cases.

Suppression of Plasmodium falciparum infection by Microsporidia MB in wild Anopheles arabiensis populations

The paper shows that Microsporidia MB in wild Anopheles arabiensis mosquitoes reduces Plasmodium falciparum infection odds by up to 60% depending on symbiont intensity.

Lowly polymorphic pathogen proteins may not be under evolutionary constraint

The paper argues that low diversity in pathogen proteins does not necessarily indicate evolutionary constraint and introduces a tool to explore diversity and divergence in Plasmodium falciparum proteins.

Prenatal immune priming to Plasmodium falciparum is characterized by multi-lineage T-cell responses that are influenced by maternal microchimerism and predict malaria outcomes

Maternal microchimerism in Malian cord blood is associated with fewer Pf-responsive ZBTB16+ CD4 and Vγ9Vδ2 T cells, and with infant malaria outcomes.

PlasmoRhythm: A comprehensive database for malaria-associated rhythmic transcripts, proteins, and metabolites

PlasmoRhythm integrates time-resolved omics data from malaria parasites, hosts, and vectors to enable comparative analysis of rhythmic molecular profiles.

Genetic surveillance of target site mutations and copy number variants associated with the escalating insecticide resistance in Anopheles gambiae (s.l.) in Ghana

The paper identifies target-site mutations and copy number variants in Anopheles gambiae s.l. from Ghana, showing their association with insecticide resistance across different intervention sites.

Evolutionarily Conserved Plasmodium falciparum HSP70-3 Enhances the Immunogenicity of the Established Malaria Vaccine Antigen Circumsporozoite Protein through Cross-Presentation

This paper shows that PfHSP70-3-SBD enhances PfCSP immunogenicity through cross-presentation, improving vaccine efficacy against malaria.

Nanopore sequencing reveals the DNA replication timing programme of the malaria parasite Plasmodium falciparum

This study uses nanopore sequencing to determine the replication timing programme of Plasmodium falciparum and links it to DNA breaking and replication fork stalling.

Identification of Adjuvants that Enhance the Magnitude and Durability of Antibody Responses to a Nanoparticle-Based Malaria Vaccine

A silent intergenic locus for efficient and versatile transgene expression in Plasmodium falciparum

The paper identifies a silent intergenic locus in Plasmodium falciparum that allows stable transgene expression without disrupting native genes, enabling versatile genetic engineering.

Repeated malaria exposure reprograms Vδ2+ γδT cell chromatin accessibility and immune function toward a reversible hyporesponsive state

Protective near-germline antibodies to malaria elicited by RTS,S/AS01E vaccination in African infants

This study identifies potent antimalarial antibodies in African infants vaccinated with RTS,S/AS01E, showing near-germline configurations and protective efficacy.

Multi-omic profiling of Plasmodium knowlesi blood stages identifies host adaptation barriers

This study identifies host adaptation barriers in Plasmodium knowlesi by analyzing multi-omic data from parasites cultured in human and macaque red blood cells.

Whole-genome characterization of Plasmodium falciparum population structure and drug resistance across Uganda and neighboring countries

The paper characterizes the population structure and drug resistance of Plasmodium falciparum in Uganda and neighboring countries using whole-genome data, identifying key resistance-associated haplotypes.

PfPHAST: Plasmodium falciparum Public Health Amplicon Sequencing Tool, a Streamlined Panel for Malaria Genomic Surveillance

PfPHAST is a streamlined amplicon sequencing panel for malaria genomic surveillance, offering better quality control and cost efficiency than MAD4HatTeR without sacrificing performance on shared targets.

De novo minibinders targeting RH5 achieve nanomolar inhibition of blood-stage malaria replication

This paper designs de novo minibinders that inhibit blood-stage malaria replication with nanomolar potency by targeting the RH5-basigin interaction.

Additional blood meals increase mosquito infectivity by accelerating the transcriptional development of Plasmodium sporozoites

The paper shows that additional blood meals increase Plasmodium falciparum sporozoite infectivity to hepatocytes by altering their transcriptional profiles.

Spatial patterns of mosquito communities and monkey malaria vectors in a tropical riverine forest in Sabah, Malaysian Borneo

The paper surveys mosquito communities in a tropical riverine forest, finding Anopheles species near rivers and detecting simian malaria parasites, suggesting zoonotic transmission risks.

L-lactate is a regulator of gametocytogenesis in Plasmodium falciparum

This paper shows that L-lactate promotes gametocytogenesis in Plasmodium falciparum by inducing histone lactylation and regulating the GDV-1/AP2-G epigenetic pathway.

Plasmodium berghei is resistant to aryl amino acetamides that inhibit P. falciparum growth by targeting the phospholipid transfer protein PfSTART1.

This paper identifies MMV006833 as an inhibitor of PfSTART1 in P. falciparum but shows it is ineffective against P. berghei due to structural differences and other factors.

Isoleucine absence from adult human hemoglobin is mirrored in mosquito proteomes and limits malaria parasite growth

The paper shows that isoleucine deficiency in human hemoglobin mirrors mosquito proteomes and limits malaria parasite growth.

Early mosquito immune patterns correlate with differential Plasmodium falciparum ookinete load

The study examines how immune responses in Anopheles mosquitoes correlate with Plasmodium falciparum ookinete load during early infection, finding that lower parasite loads are associated with stronger immune gene upregulation.

Genetic background determines allele-specific Pfkelch13-mediated artemisinin tolerance and persistence in Plasmodium falciparum

The paper shows that genetic background influences whether Pfkelch13 mutations confer short-term artemisinin tolerance or long-term persistence in Plasmodium falciparum.

Dynamic phosphorylation of the Plasmodium falciparum Myosin A motor regulates motor speed and is important for asexual replication

This study shows that phosphorylation of Plasmodium falciparum MyoA at Ser19 dynamically regulates motor speed and is essential for asexual replication.

Understanding malaria transmission in Angola: first detection of Plasmodium malariae in Anopheles spp. and the role of secondary vectors in the Balombo region, Benguela Province