Antibiotic Resistance in Bacteria

This study investigates how different antibiotic pre-treatments affect gut microbiome perturbation and the conjugative transfer of antimicrobial resistance genes in mice.

This study identifies parallel genetic mutations in A. baumannii that lead to phenotypic changes, revealing distinct adaptability mechanisms and challenging assumptions about capsule loss and antibiotic resistance.

This paper reclassifies SHV β-lactamase alleles in K. pneumoniae genomes based on mutations, improving genotype-phenotype understanding and updating the Kleborate tool.

This study sequenced and analyzed the genome of a multidrug-resistant Serratia marcescens strain to identify antibiotic resistance genes and genomic diversity.

This paper evaluates a GPT-4-based agent for detecting antimicrobial resistance mechanisms in Gram-negative bacteria, finding it less accurate and specific than human experts.

The paper identifies multidrug-resistant Klebsiella pneumoniae strains circulating between chimpanzees, termites, and humans in Senegal, showing genetic similarity across species.

The paper evaluates metagenomic assembly tools' ability to recover antibiotic resistance gene (ARG) genomic contexts, finding that Trinity performs better than metaSPAdes and MEGAHIT in reconstructing accurate ARG-containing contigs.

The paper investigates whether flumequine selects for the same resistance mechanisms in E. coli as enrofloxacin, finding similar SNPs in gyrA and comparable resistance rates.

This study identifies PhoPQ-mediated LPS modification via EptB as a mechanism conferring resistance to tetracycline and glycylcycline antibiotics in E. coli.

This study shows minocycline enhances macrophage killing of Acinetobacter baumannii and reduces inflammation in a dose-dependent manner, suggesting improved in vivo efficacy.

This study shows that Pseudomonas aeruginosa resistance to aminoglycosides is heterogeneous, with mexZ mutations improving survival by bypassing slow MexXY activation, and introduces a 'Response Dynamics' assay to measure resistance in fluctuating drug environments.

The paper uses whole genome sequencing to show high diversity and transmission of ESBL-Ec across human, animal, and environmental compartments in low-income settings, supporting the One Health approach for AMR control.

The paper analyzes the potential transfer of antimicrobial resistance genes by strain VE202-06 and concludes there is no risk of vancomycin resistance transfer.

The paper reassesses the taxonomy of Enterococcus casseliflavus and related species using genomic data, identifying three clusters and refining species boundaries.

This study investigates the relationship between CRISPR/Cas systems and antimicrobial resistance in Klebsiella pneumoniae isolates from Iraq, finding an inverse correlation between CRISPR presence and resistance levels.

This paper characterizes the carbapenem-resistant Acinetobacter baumannii isolate BAL062, detailing its resistance properties and capsular polysaccharide structure using NMR spectroscopy.

This paper introduces a protein language model to predict antibiotic resistance mechanisms in ARGs, showing improved performance and interpretability on diverse datasets.

The paper identifies soil bacteria as potential natural reservoirs of drug resistance genes by showing they harbor extensive resistance despite not colonizing humans/animals.

The paper compares plasmids from pre-antibiotic era bacteria with modern plasmids to show how resistance genes evolved and spread over time.

This study shows that artesunate, EDTA, and colistin work together to fight Salmonella strains resistant to colistin, by damaging cell membranes and inhibiting MCR-1.

The paper identifies a plasmid lineage pQEB1 carrying blaKPC-2 in a hospital outbreak, showing its multi-drug resistance and inter-patient transmission.

This study shows that IncC plasmid genome rearrangements enhance horizontal transmission while maintaining bacterial fitness, suggesting a strategy for plasmid dissemination.

This study shows plasmid-encoded insertion sequences (IS1) enhance bacterial adaptation by increasing gene inactivation rates in clinical enterobacteria.

The paper characterizes the genetic resistance mechanisms in a multidrug-resistant Acinetobacter baumannii isolate, identifying plasmid-borne mcr-1 and chromosomal carbapenemase genes linked to replicative transposition and genomic plasticity.

The paper shows natural products can reduce AMR plasmid transmission in Enterobacterales, with rottlerin being particularly effective against K. pneumoniae.

This study investigates TolC protein dynamics in Gram-negative bacteria, identifying structural shifts that facilitate β-lactam efflux and resistance, with implications for antibiotic design.

The paper analyzes ESBL-producing E. coli genomes and wastewater metagenomes to understand antibiotic resistance gene distribution and co-occurrence in Oregon wastewater systems.

This study investigates the molecular mechanisms of cefiderocol resistance and antagonism with avibactam and sulbactam in carbapenem-resistant Acinetobacter strains.

The paper analyzes whole genome sequencing data from a multidrug-resistant Shigella sonnei outbreak in Tunisia, identifying resistance genes and genetic relationships with European strains.

This study uses QSP modeling and population genomics to show that baseline resistance mechanisms in Pseudomonas aeruginosa affect bacterial killing and resistance emergence, and that fT>MIC cannot predict these outcomes.