Mosquito-borne diseases and control

This study examines how gentrification in Miami-Dade County affects mosquito community composition and diversity using socioeconomic and mosquito control data.

This study shows that 25-hydroxycholesterol inhibits Japanese encephalitis virus infection in Vero cells with an IC50 of 4.18 µM and no cell toxicity.

This study systematically reviews temperature effects on arboviral extrinsic incubation periods, finding significant heterogeneity across viruses and mosquito species.

This study identifies a naturally occurring salivary gland barrier in NAK Ae. aegypti mosquitoes that significantly reduces ZIKV transmission potential, offering a new strategy for vector control.

This study identifies three HS-binding sites on EEEV E2 glycoprotein that contribute to both HS and protein receptor-dependent infection, affecting disease and mosquito infectivity.

This study evaluates cyclodextrins' ability to reduce endothelial dysfunction and antiviral activity against DENV and SARS-CoV-2 in vitro and in vivo.

This study models the spread of Aedes albopictus in France and finds its range is expanding due to climate change, increasing dengue transmission risk in Western Europe.

This study predicts future West Nile Virus risk in the UK by combining species distribution models of vectors, hosts, and climate scenarios.

This study finds that climate change has lengthened the West Nile virus transmission season in New York State by 19.7 days over 25 years and 29.6 days over 45 years, increasing disease risk.

This study uses a diabetic mouse model to show that hyperglycemia worsens Chikungunya virus-induced joint damage, inflammation, and organ injury, providing insights into why diabetic patients experience more severe outcomes.

This study shows that Culex pipiens molestus mosquitoes can transmit Usutu virus at 22°C, with higher viral loads and transmission rates compared to lower temperatures.

This study develops an ENTV infectious clone and evaluates its replication in mosquito cells and mosquitoes, revealing host-specific replication patterns and midgut barriers to transmission.

This paper develops insect-specific alphavirus chimeric vaccines for chikungunya and Ross River viruses, showing efficacy in protecting against disease but no cross-protection.

This study identifies HuR as a dual regulator of DENV infection, suppressing replication early and promoting cap-independent translation later.

The paper identifies 149 putative interactors of ZIKV-C in human neural stem cells, highlighting interactions with the nucleus and mitochondria and linking some proteins to neurodevelopmental diseases.

This study sequences and analyzes MVEV isolates from the Ralph Doherty collection, identifies new genotypes, and establishes mouse models of MVEV disease.

This study shows that metabolic homeostasis enables tolerance to persistent viral infection in Aedes aegypti mosquitoes, with ZacP mosquitoes showing greater tolerance than LVP.

The paper develops mRNA-LNP vaccines encoding optimized prM/ENV proteins for all four DENV serotypes that induce protective immunity and reduce antibody-dependent enhancement.

The paper describes the enantioselective resolution of a chemical probe targeting CHIKV nsP2 helicase, showing potent antiviral activity for one enantiomer and low activity for the other.

This study shows NAT10 regulates ZIKV infection by modulating stability of innate immune mRNAs, leading to altered viral replication and immune response.

The paper reports the detection of West Nile virus RNA in mosquito pools from the UK, indicating a historic presence of the virus in the region.

The paper introduces Ceudovitox, a pseudotyped-virus screening platform that identifies cell entry factors for high consequence infections, demonstrating its effectiveness in discovering novel factors like matrix metalloproteinases for CHIKV.

This study identifies KLC1 as a host susceptibility factor for dengue virus in mosquito cells by showing its interaction with NS1 and role in lipid droplet homeostasis.

This study uses QIC-seq to compare host factor requirements and transcriptional responses to flavivirus infections, revealing differences in dependency on cellular pathways.

This study optimized a colorimetric assay to identify inhibitors of ZIKV RdRp, finding two compounds with inhibitory activity.

This paper introduces a modified forced oviposition method for Culex quinquefasciatus and Aedes aegypti, showing that smaller containers increase oviposition rates and that the method is effective for generating F1 progeny for vector research.

This study shows that G-CSF protects against arthritogenic alphavirus disease through type I IFN signaling in mice.