Lymphoma Diagnosis and Treatment

Shared genetic features between lymphoma pathogenesis and oestrogen levels.

This study identifies sex-specific genetic variants associated with lymphoma subtypes and oestrogen levels, revealing shared biological pathways influenced by oestrogen.

Sequencing analysis of Helicobacter pylori infection in gastric mucosa and its progression to gastric mucosa-associated tissue (MALT) lymphoma

The paper analyzes sequencing data from gastric MALT lymphoma patients to identify genetic mutations, gene fusions, and microbiome changes associated with H. pylori infection and disease progression.

Quantitative modelling of signaling in aggressive B cell lymphoma unveils conserved core network

The paper models BCR signaling in B cell lymphoma cells to identify conserved network structures and crosstalk mechanisms.

Revisiting Reddy: A DLBCL Do-over

The paper reanalyzes Reddy et al.'s 2017 DLBCL study, revealing discrepancies in mutation detection and outcome associations that render their findings non-replicable.

Ultra Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma

This study uses ultra-deep exome sequencing to identify recurrent mutations in classical Hodgkin lymphoma HRS cells, demonstrating its utility for analyzing genomic variants in large patient cohorts.

Integrated single cell analysis reveals co-evolution of malignant B cells and the tumor microenvironment in transformed follicular lymphoma

The paper uses single-cell sequencing to study the evolution of follicular lymphoma and its microenvironment during transformation, finding gene programs and TME changes associated with progression.

Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphoma

This study identifies subtype-specific and co-occurring genetic alterations across major B-NHL subtypes using targeted sequencing of 380 genes in 685 tumors.

An IPI based immune prognostic model for diffuse large B-cell lymphoma

The paper constructs an IPI-based immune prognostic model for DLBCL using gene expression data, showing high-risk patients have shorter survival and higher potential response to ICB therapy.

CREBBP and STAT6 co-mutation and 16p13 and 1p36 loss define the t(14;18)-negative diffuse variant of follicular lymphoma

This study identifies genetic and pathologic features of t(14;18)-negative diffuse follicular lymphoma, showing recurrent 16p13 and 1p36 deletions, CREBBP and STAT6 mutations, and co-mutations.

Coding and regulatory drivers of mantle cell lymphoma identified through exome and genome sequencing

This study identifies genetic drivers of mantle cell lymphoma through exome and genome sequencing, revealing novel mutations in genes involved in RNA splicing and regulation.

Identification of Familial Hodgkin Lymphoma Predisposing Genes Using Whole Genome Sequencing

This study uses whole genome sequencing to identify potential familial Hodgkin lymphoma predisposing genes in three families, finding a novel DICER1 variant in one family.

Genomic profiling of circulating tumor DNA reveals genetics and residual disease in NK/T lymphoma

This study uses ctDNA analysis to identify genetic mutations and monitor residual disease in NK/T lymphoma patients, finding KMT2D mutations correlate with poor prognosis and treatment response.

Targetable genetic alterations of TCF4 (E2-2) drive immunoglobulin expression in the activated B-cell subtype of diffuse large B-cell lymphoma

The paper identifies TCF4 overexpression driven by 18q21.2 gains as a mechanism promoting IgM expression in ABC-like DLBCL and shows BET inhibitors can suppress it.

Single nucleotide polymorphisms of the c-MYC gene’s relationship with formation of Burkitt’s lymphoma using bioinformatics analysis

This study investigates the relationship between c-MYC gene SNPs and Burkitt’s lymphoma formation using bioinformatics analysis of 286 SNPs, identifying eight potentially disease-causing variants.

Genome-wide discovery of somatic coding and regulatory variants in Diffuse Large B-cell Lymphoma

This study identifies somatic coding and regulatory variants in DLBCL, revealing novel mechanisms of oncogene deregulation and potential therapeutic targets.

Malaria and Burkitt’s Lymphoma: An In Silico Analysis of Gene Expression Links between Malaria and Burkitt’s Lymphoma and Potential Anticancer Activity of Artemisinin Derivatives

The paper identifies molecular overlaps between malaria and Burkitt’s lymphoma and links artemisinin derivatives to shared pathways that could inform their anticancer potential.