Electrochemical sensors and biosensors

Real-Time Neurotransmitter Sensing in Midbrain Organoids Using 3D Carbon Cup Electrodes

This paper introduces 3D carbon cup electrodes for real-time, chemically selective detection of neurotransmitter release in midbrain organoids, demonstrating dopamine sensing and validating the platform with chemical perturbations.

Direct electrochemical cortisol detection via transition-resolved interrogation at a defect-engineered graphene interface

This paper develops a method for direct electrochemical cortisol detection using a defect-engineered graphene interface and transition-resolved interrogation, achieving sensitive and selective detection in biological fluids.

Rapid Electrochemical Biosensing of Listeria monocytogenes Using Rationally Designed Host-Pathogen Interface Peptides

This paper develops a biosensor using host-pathogen interaction peptides to rapidly detect Listeria monocytogenes with high selectivity and sensitivity.

SMART-NeuroDx: A Reagent-Free Multianalyte Biosensor Platform with Machine-Learning Readout for Point-of-Care Dementia Screening

SMART-NeuroDx is a reagent-free electrochemical biosensor that simultaneously detects four dementia biomarkers in unprocessed blood samples using machine learning for accurate quantification.

AI-guided Protein Inhibitor Design for Modulating FAD-dependent Glucose Dehydrogenase Redox Output

This paper develops an AI-guided method to design protein inhibitors that modulate FAD-GDH redox output, demonstrating their effectiveness in reducing GDH-mediated redox activity.

Tuning selectivity of electrochemical sensors with polymer coatings

This study shows that polymer coatings can tune the oxidation potentials of biomarkers, improving selectivity in electrochemical sensors for molecular discrimination.

Smartphone-Validated Portable Paper-Based Device Integrated with an Electropolymerized Molecularly Imprinted Polymer for Serotonin Detection in Serum Samples

This paper develops a portable, smartphone-compatible electrochemical sensor for serotonin detection in serum, demonstrating high sensitivity, selectivity, and reliability in clinical samples.

Machine Learning-Driven Multiplexed Biomarker Detection with Polymer-Enhanced Electrochemical Sensors

This paper develops a polymer-modified electrochemical sensor array combined with machine learning to accurately detect multiple biomarkers in complex mixtures.

Single-chip End-to-End Ingestible Electronics for Gut Neurotransmitter Sensing

This paper develops an ingestible pill for real-time in vivo sensing of serotonin and dopamine in the gut using a fully integrated electrochemical sensor and ASIC.

Sensitive Hormone and Neurotransmitter Detection with Carbon Flower Electrodes

This paper develops carbon flower sensors for sensitive and selective detection of hormones and neurotransmitters in complex biofluids.

Electrical Readout Strategies of GFET Biosensors for Real-World Requirements

This study compares amperometric and potentiometric readout strategies for GFET biosensors, finding that transconductance offers better detection limits but lower reproducibility, while Dirac point tracking provides higher robustness but worse limits of detection.

A nicotine biosensor derived from microbial screening

The paper develops a nicotine biosensor using a microbial-derived redox enzyme, demonstrating detection over a clinically relevant range.

Antibacterial wound dressing enables reliable detection of uric acid in exudates.

This paper develops an antibacterial wound dressing with integrated uric acid sensing capability for wound healing and recovery monitoring.

Toward Textile-Integrated Electrochemical Systems: A Flexible PCB Potentiostat for Wearable Glucose Monitoring

This study develops a flexible PCB potentiostat integrated with a glucose biosensor on polyimide filament for wearable glucose monitoring in artificial sweat.

A Novel Approach to Fabricating Sustainable Enzymatic Lactate Biofuel Cells Using Direct Laser Writing Technology for Wearable Real-Time Monitoring Applications

This paper develops a lactate/oxygen enzymatic biofuel cell using laser-induced graphene electrodes for real-time wearable biosensing, showing linear power density increase with lactate concentration.

Horseradish peroxidase as an electrochemical reporter protein for cell-free biosensors

This paper evaluates horseradish peroxidase (HRP) as an electrochemical reporter for cell-free biosensors, showing it produces a strong current and responds to regulatory signals.

Highly Efficient Coreactant-Free Electrochemiluminescence Sensing Platform Using Novel Microfabricated Multiplexed Entwined Spiral Microelectrodes for Point-of-Care Applications

This paper develops a coreactant-free ECL sensing platform with entwined spiral microelectrodes for sensitive, multiplexed POC diagnostics.

Wearable sweat nicotine biosensor based on a nicotineoxidoreductase and its natural electron acceptor

This paper develops a wearable nicotine biosensor using NicA2 and CycN, achieving high sensitivity and selectivity for real-time sweat monitoring.

Algorithm-Powered Analyzer for Continuous Electrochemistry: A Toolkit for Real-Time Electrochemical Data Analysis

The paper introduces A-PACE, an open-source toolkit for real-time electrochemical data analysis, improving peak detection, baseline fitting, and data processing efficiency.

Minimally invasive and in situ capacitive sensing of cardiac biomarker from interstitial fluid

This paper introduces a microneedle-based capacitive biosensor for in situ detection of cardiac troponin I in interstitial fluid, showing high sensitivity and rapid results.

Development of a Microelectrode Array System for Simultaneous Measurement of Field Potential and Glutamate Release in Brain Slices

This paper develops a microelectrode array system to simultaneously measure field potential and neurotransmitter release in brain slices, demonstrating its ability to detect glutamate and dopamine release and their dynamic changes following caffeine administration.

Wound state monitoring by multiplexed, electrochemical, real-time, localized, inflammation-tracking nitric oxide sensor (MERLIN)

The paper introduces MERLIN, a sensor for real-time, localized NO detection in wounds, showing NO peaks on day 3 post-injury in rat models.

Covalent conjugation of glucose oxidase on single-walled carbon nanotubes for glucose sensing

This paper develops a covalent conjugation method to attach glucose oxidase to single-walled carbon nanotubes for improved glucose sensing performance and stability.

All-Diamond Boron-Doped Microelectrodes for Neurochemical Sensing with Fast-Scan Cyclic Voltammetry

This paper develops and tests all-diamond boron-doped microelectrodes for neurochemical sensing using fast-scan cyclic voltammetry, showing improved detection of serotonin compared to dopamine.

Self-Assembled Monolayer Transporters Enable Reagentless Analysis of Small Molecule Analytes

This paper introduces a reagentless electrochemical method using self-assembled monolayers to detect small molecules in biological fluids.

Incorporating Microbial Pilin-Based Nanowires into a Water-Stable Electronic Polymer Composite

This study creates a water-stable conductive composite using microbial pilin-based nanowires and demonstrates its use as a sensitive ammonia sensor with tunable response.

An electrochemical approach for rapid, sensitive, and selective detection of dynorphin

This paper develops microimmunoelectrodes for electrochemical detection of dynorphin, showing sensitivity in the attomolar range and selectivity over other opioids.

Electrochemical Detection of Adrenaline and Hydrogen Peroxide on Carbon Nanotube Electrodes

This paper develops carbon nanotube-coated electrodes for electrochemical detection of adrenaline and hydrogen peroxide, showing improved sensitivity and reduced overpotentials compared to graphite.

Low amplitude burst detection of catecholamines

This paper introduces a machine learning method to concurrently detect dopamine, norepinephrine, and serotonin with sub-second resolution in conscious humans.

Phasic oxygen dynamics underlies fast choline-sensitive biosensor signals in the brain of behaving rodents

The paper develops a new biosensor to measure cholinergic activity and oxygen in behaving rodents, revealing that oxygen dynamics influence biosensor signals and challenge previous interpretations of cholinergic transients.