Functional Brain Connectivity Studies

Structural integrity moderates the cognitive bearing of dopamine clearance in aging

The paper develops ADAM, a model linking dopamine clearance and structural connectivity to cognitive aging, finding elevated clearance timescales and a structure-age-dependent association with cognitive performance.

An information-borrowing Bayesian method for inferring high-dimensional population-level brain connectivity from small samples

The paper introduces a Bayesian method for estimating population-level brain connectivity from small samples, showing improved accuracy over existing methods in simulations and real data.

Distinct EEG microstate signatures across different pain types

This study identifies distinct EEG microstate patterns across different pain types, showing that microstate C differentiates experimental and clinical pain.

Alignment with sex-typical brain architecture: Links to mood pathology, sex hormones and transcriptomics of neurodegenerative conditions

The paper investigates how alignment with female-typical brain functional connectivity patterns relates to mood disorders and neurodegenerative conditions, finding overlaps with gene expression profiles linked to sex hormones and disease.

Reliable Evaluation of Transductive Population Graph Neural Networks for Multisite Autism fMRI

Site-aware population GNN on ABIDE-I: cohort AUC about 0.94 (kept with site-only edges) was not reproduced by a site-prior classifier (0.506); a directed-edge support gain (+0.252) vanished when symmetrised (−0.003).

Regional alignment with sex-typical brain architecture, maternal health and environmental enrichment predict psychiatric symptoms in early life

The paper shows that neonatal brain alignment with sex-typical functional connectivity patterns predicts psychiatric symptoms in toddlers, with different outcomes for female- and male-typical patterns.

AREION: A Foundation Model for Atlas-Agnostic Representation Learning of Brain Connectome

AREION learns atlas-agnostic representations of brain connectomes, outperforming baselines with fewer parameters and strong transferability across atlases.

Higher-order topology uncovers the multidimensional dynamics of naturalistic emotion

This paper uses higher-order topology to analyze brain activity during naturalistic emotion tasks, finding that it captures fine-grained affective structure while pairwise connectivity captures broad arousal.

Different functional connectivity gradients reflect aging and Alzheimer's disease

The paper shows aging and Alzheimer's disease alter distinct functional connectivity axes in the brain, with AD affecting the sensory-association axis and aging affecting the representation-executive axis.

Assessing the Functional-Structural Reorganization of Connector Hubs in Temporal Lobe Epilepsy

This study examines how connector hubs in temporal lobe epilepsy patients reorganize compared to healthy controls, finding widespread hub reductions and new hub emergence in contralateral regions.

VRPTR prediction of individual language activation and uncertainty from resting state fMRI

VRPTR predicts individual language activation from resting-state fMRI with improved correlation over baseline models, while providing calibrated uncertainty estimates.

Myelin-weighted Core Network Connectivity Supports Trait-Level Future Thinking

The paper links structural brain network properties to individual differences in future thinking abilities using MRI and psychometric data.

Unveiling functional-metabolic synergy in the healthy brain: multivariate integration of dynamic FDG-PET and resting-state fMRI

This paper uses multivariate PLSC to analyze functional-metabolic coupling in the brain, finding strong links between fMRI-derived functional connectivity and glucose metabolism parameters.

Saccadic network dysfunction underlies eye-movement variability in early Parkinson's disease

This study identifies increased intra-individual saccadic variability and altered functional connectivity in early Parkinson's disease, showing their potential as biomarkers for early diagnosis.

Higher-order interdependencies of the epileptogenic network in presurgical resting-state fMRI

The paper uses multivariate information theory to analyze higher-order network interactions in drug-resistant focal epilepsy patients using resting-state fMRI, finding that redundant information-sharing dominates epileptogenic networks and correlates with surgical outcomes.

Hippocampal and large-scale functional connectivity reorganization following freediving training, and relationships with episodic memory

This study examines functional connectivity changes in the hippocampus and brain networks of freedivers before and after training, finding reorganization linked to preserved episodic memory.

Evaluating the value and limits of null-models for Lesion Network Mapping

This paper evaluates null models for Lesion Network Mapping, showing they replace the connectome matrix but do not resolve non-specificity across conditions.

Intrinsic timescale develops hierarchically from sensorimotor to association cortex in youth and stabilizes in adulthood

Resting-state fMRI intrinsic timescale lengthens with age in association, not sensorimotor, cortex during ages 8-22, following the sensorimotor-association axis in two cohorts; it is largely age-stable in young adults.

Normative Modeling of Molecular-Enriched Functional Connectivity for Detecting Deviations from Healthy Brain Aging

This paper develops normative models to detect deviations in molecular-enriched functional connectivity associated with amyloid burden in healthy aging brains.

A Comparison of Brain Metabolic Connectivity Methods Topology, Cognition, Age, Structure, and Genetics

This paper compares brain metabolic connectivity methods using PET and fMRI data, finding that different approaches yield distinct topological, cognitive, structural, and genetic signatures, with fPET showing strongest cognitive associations and age-related declines.

Brain age prediction from structural and functional connectivity across the lifespan using connectome-based predictive modeling

This study uses connectome-based predictive modeling to predict chronological age from structural and functional brain connectivity across different lifespan stages and finds that both modalities contribute complementary age-related information.

TE-aware state analysis and evolution in dynamic network connectivity

The paper analyzes how dynamic brain connectivity states change across different echo times (TEs) in fMRI data using a bi-exponential model and finds TE-dependent variance and state transitions.

Divergence in neurodivergent brains: mapping the relationship between developmental trajectories in functional connectivity and clinical outcomes

The paper examines age-related changes in functional connectivity and clinical outcomes in neurodivergent and neurotypical youth, finding divergence in connectivity patterns during adolescence that precedes clinical differences.

An fMRI dysmaturity signature in preterm neonates: Responsiveness of brain areas and its relation to newborn brain development

This paper introduces response-based metrics to capture dynamic brain organization in preterm neonates, finding reduced responsiveness and preserved hierarchical structure despite developmental delays.

Concordance between the fast and efficient mixed-effects algorithm (FEMA) and conventional mixed-effects modeling for whole-brain connectivity in longitudinal chronic pain

The paper benchmarks the Fast and Efficient Mixed-Effects Algorithm (FEMA) against conventional mixed-effects modeling for longitudinal neuroimaging data and finds high concordance with minor differences in variance component estimates.

Frontoparietal effective connectivity supports working memory in early childhood

This study examines how age and task performance influence frontoparietal effective connectivity during a visuospatial working memory task in children.

Topographic and somatotopic organization of functional connectivity between the intraparietal sulcus and primary somatosensory cortex in macaque monkeys

Age-related reorganization of locus coeruleus-cortical functional connectivity gradients

This study examines age-related changes in locus coeruleus-cortical functional connectivity gradients using MRI and PET data, finding reduced functional differentiation in older adults during negative emotional stimuli.

Structure-function coupling reveals hemisphere-specific network reorganization after stroke

The paper examines structural and functional connectivity coupling in the mouse brain after stroke, revealing hemisphere-specific network reorganization that is not detectable when analyzing structural and functional connectivity separately.

Parent-Child Cortical Similarity Indexes Multiple Dimensions of Sensitivity in the Association Between Family Environment and Adolescent Internalizing Symptoms

The paper examines how parent-child cortical similarity moderates the effect of family environment on adolescent internalizing symptoms across different cortical systems.