Oral microbiology and periodontitis research

Fusobacterium nucleatum is enriched in invasive biofilms in colorectal cancer

Multi-probe imaging and 16S rRNA profiling of Malaysian colorectal cancers show that Fusobacterium nucleatum, dominated by subspecies animalis clade 2, is enriched specifically within mucus-invasive tumor biofilms.

On the Impact of Smoking on The Oral-brain Axis: The Microbiome-Metabolism-Brain Interactions

This study examines how smoking affects interactions between the oral microbiome, metabolism, and psychological traits using multi-omics datasets and network analysis.

Inter-Kingdom Interactions and Environmental Influences on the Oral Microbiome in Severe Early Childhood Caries

This study examines bacterial-fungal dynamics in severe early childhood caries, finding reduced bacterial diversity, increased cariogenic species, and a role for Candida albicans, while showing no link between iron/fluoride and microbial communities.

Complete genome sequences of Fusobacterium watanabei sp. isolates

The paper reports the complete genome sequences of eight clinical isolates of Fusobacterium watanabei and classifies them within the 'Fusobacterium nucleatum_J' group.

Mechanistic Modeling of Periodontal Pathogen Fusobacterium nucleatum-Induced Epithelial Oncogenic Transformation in Carcinomas via Selected FadA-Lactate-Angiogenesis Pathway

This study models how Fusobacterium nucleatum induces epithelial oncogenic transformation through the FadA-lactate-angiogenesis pathway, identifying lactate accumulation and VEGF upregulation as key factors in cancer progression.

A Strain of Streptococcus mitis Inhibits Biofilm Formation of Caries Pathogens via Abundant Hydrogen Peroxide Production

This study identifies a Streptococcus mitis strain that inhibits biofilm formation of S. mutans through high hydrogen peroxide production, but is less effective against pre-formed biofilms.

Streptococcus mutans LiaS gene regulates its cross-kingdom interactions with Candida albicans to promote oral candidiasis

This study shows that the S. mutans LiaS gene regulates cross-kingdom interactions with C. albicans, reducing hyphal formation and biofilm production in dual-species infections.

Mechanism Underlying Carvacrol-induced Alveolar Bone Repair via the Phosphatidylinositol 3-kinase Pathway in Periodontal Disease

This study shows carvacrol hydrogel promotes alveolar bone repair by activating the PI3K pathway and reducing inflammation in periodontal disease.

In Vitro Evaluation of Anti-Inflammatory, Anti-Plaque Efficacy, and Biocompatibility of Norway Spruce (Picea abies) Resin Extract for Oral Care Applications

Biological Drivers of Early Childhood Caries in Preschool Children of Northern Arizona and Hawaii

This study investigates the relationship between demographic factors, S. mutans colonization, and early childhood caries risk in preschool children from northern Arizona and Hawaii.

Streptococcus abundance and oral site tropism in humans and non-human primates reflects host and lifestyle differences

The paper examines Streptococcus clade abundance in humans and non-human primates, finding conserved clade dominance across oral sites and lifestyle-related differences in species presence.

Characterization of Clinical Fusobacterium nucleatum Isolates from Oral Squamous Cell Carcinoma Patients

This study characterizes Fusobacterium nucleatum isolates from oral squamous cell carcinoma patients and non-cancer individuals, revealing differences in virulence traits and cancer cell interactions.

Associations between oral microbiota pathogens and elevated depressive and anxiety symptoms in men

This study examines the link between oral microbiota pathogens and depressive/anxiety symptoms in men, finding associations with specific bacterial species but not overall microbial diversity.

Association Between Oral Microbiota and Close-Range Proximity in a Primary School

This study examines the link between close-range proximity and oral microbiota similarity in children, finding that more time spent in proximity correlates with greater microbiota similarity.

Diversity and characteristics of the oral microbiome influenced by race and ethnicity

The paper analyzes oral microbiome diversity and functional potential across racial/ethnic groups, finding higher virulence and antibiotic resistance in African American and Hispanic American populations.

HDAC6-Mediated FoxO1 Acetylation And Phosphorylation Control Periodontal Inflammatory Responses

This study identifies HDAC6's role in regulating FoxO1 acetylation and phosphorylation to control periodontal inflammation, showing reduced inflammation and bone loss in HDAC6-deficient models.

Quantifying synthetic bacterial community composition with flow cytometry: efficacy in mock communities and challenges in co-cultures

This study evaluates flow cytometry's ability to quantify synthetic bacterial communities, showing it outperforms PCR-based methods in mock communities but faces challenges in co-cultures due to phenotypic changes.

Neutrophils drive sexual dimorphism in experimental periodontitis

This study investigates sex-specific differences in periodontitis progression, finding that neutrophil inflammation drives sexual dimorphism in bone loss.

Microbial dysbiosis is evident in oral squamous cell carcinoma (OSCC) tissues of a group of Sri Lankan male patients with oral risk habits: Revisiting for confirming

This study identifies microbial dysbiosis in OSCC tissues of Sri Lankan male patients with oral risk habits, highlighting specific pathogens and their associations with oral cancer.

Identification of V. parvula and S. gordonii adhesins mediating co-aggregation and its impact on physiology and mixed biofilm structure

This study identifies adhesins in V. parvula and S. gordonii that mediate co-aggregation and shows its role in biofilm structure without affecting cell-cell communication.

Nepali oral microbiomes reflect a gradient of lifestyles from traditional to industrialized

This study examines oral microbiomes of Nepali individuals with different lifestyles, finding that lifestyle, not geography, shapes microbiome composition across a gradient from foraging to industrialized.

The protease interpain A of Prevotella intermedia promotes human oral squamous cell carcinoma cells proliferation and migration

This study identifies interpain A (InpA) from Prevotella intermedia as a protease that promotes oral squamous cell carcinoma cell proliferation and migration via PAR-2 signaling.

Altered oral microbiota of drug-resistant organism carriers exhibit impaired gram-negative pathogen inhibition

The paper examines oral microbiota differences between individuals carrying multidrug-resistant gram-negative bacilli and non-carriers, finding reduced inhibition of pathogens and altered resistome profiles.

Multi-way modelling of oral microbial dynamics and host-microbiome interactions during induced gingivitis

This study uses PARAFAC to analyze oral microbiome and metabolome dynamics during experimental gingivitis, identifying microbial subcommunities and metabolic pathways linked to inflammation.

Glycerol Metabolism Contributes to Competition by Oral Streptococci through Production of Hydrogen Peroxide

This study shows that glycerol metabolism in oral commensal streptococci produces hydrogen peroxide, enhancing competition against the pathogen Streptococcus mutans.

Microscale Spatial Dysbiosis in Oral biofilms Associated with Disease

The paper examines spatial bacterial arrangement in oral biofilms from healthy and diseased implants, finding that disease is associated with single-genus patches and proposing spatial structure as a biomarker for microbiome stability.

Bacterial Protein Signatures Identified in Porphyromonas gingivalis Containing-Autophagic Vacuoles Reveal Co-Evolution Between Oral Red/Orange Complex Bacteria and Gut Bacteria

The paper identifies shared protein signatures between oral and gut bacteria, revealing co-evolutionary relationships through phylogenetic analysis and mass spectrometry.

Glutamate is a key nutrient for Porphyromonas gingivalis growth and survival during intracellular autophagic life under nutritionally limited conditions

This study shows that Porphyromonas gingivalis relies on glutamate for growth and survival in intracellular autophagic vacuoles by utilizing glutamate dehydrogenase and preferentially using glutamate-glutamate dipeptide.

Exploring Porphyromonas gingivalis Pathogenesis and Antibody Pool Effect Using a Novel Mouse Reproductive Model

This study uses a mouse model to show that a mixture of antibodies with P. gingivalis infection causes more reproductive damage than infection alone, suggesting an antibody pool effect in pathogenesis.

Spaceflight Shifts in Community rRNA Copy Number in the Salivary Microbiome of Astronauts

The paper examines how spaceflight affects the salivary microbiome by analyzing changes in rRNA copy numbers and species abundance.