Oral microbiology and periodontitis research

Bioinformatic evaluation of the potential oral-gut translocation of periodontal pathogens in patients with colorectal polyps

This study uses 16S rRNA sequencing to analyze oral and gut microbiota in colorectal polyp patients, finding shared bacterial genera between oral and intestinal environments.

Microbial functional pathways based on metatranscriptomic profiling enable effective saliva-based health assessments for precision wellness

The paper develops microbial functional pathway scores from metatranscriptomic data to assess oral health and disease phenotypes using saliva samples.

Hemin availability induces coordinated DNA methylation and gene expression changes in Porphyromonas gingivalis

This study investigates how hemin availability affects DNA methylation and gene expression in Porphyromonas gingivalis, identifying coordinated changes in six genes related to virulence.

Investigating Metabolic Trends in the Oral Cavity to Identify Novel Metabolites

This study identifies novel secondary metabolites and a metabolic lag during oral dysbiosis recovery, linking them to oral and systemic disease progression.

Metagenome-genome-wide association studies reveal human genetic impact on the oral microbiome

This study identifies genetic loci associated with the oral microbiome using metagenome-genome-wide association studies in over 1,915 individuals.

Modulation of the host cell transcriptome and epigenome by Fusobacterium nucleatum

This study investigates how three Fusobacterium nucleatum strains modulate host cell transcriptomes and epigenomes through RNA-seq and ChIP-seq, revealing inflammation-related gene upregulation and chromatin remodeling during host cell invasion.

OTUs clustering should be avoided for defining oral microbiome

This study evaluates primer pairs for 16S rRNA gene amplicon sequencing in the oral microbiome, showing that OTUs defined by 97% similarity often miscluster species, affecting diversity metrics and health-disease associations.

Single-cell atlas of human oral mucosa reveals a stromal-neutrophil axis regulating tissue immunity in health and inflammatory disease

This paper constructs a single-cell transcriptome atlas of human oral mucosa in health and periodontitis, identifying a stromal-neutrophil axis regulating tissue immunity.

Development of an oral swab based microbiome test for the detection of feline dental disease

This study develops a feline dental health test using oral microbiome data from 38,000 cats to predict periodontal disease, tooth resorption, and halitosis with varying model performance.

Proteomics, lipidomics, metabolomics and 16S rDNA sequencing of dental plaque from patients with diabetes and periodontal disease

The paper integrates proteomics, lipidomics, metabolomics, and 16S rDNA sequencing to analyze dental plaque from patients with diabetes and periodontal disease, identifying microbial and host factors associated with these conditions.

Susceptibility to gingipains and transcriptomic response to P. gingivalis highlights the ribosome, hypothalamus, and cholinergic neurons

The paper identifies genes susceptible to P. gingivalis gingipains and links them to Alzheimer's disease through ribosomal genes, hypothalamus, and cholinergic neurons.

Epigenetic findings in periodontitis in UK twins: a cross sectional study

This study identifies DNA methylation changes in blood and tissue samples associated with periodontal disease in older female twins.

A computational protocol to characterize elusive Candidate Phyla Radiation bacteria in oral environments using metagenomic data

This paper presents a computational protocol to detect Candidate Phyla Radiation bacteria from metagenomic data, enabling the reconstruction of draft genomes and functional gene analysis.