Thyroid Disorders and Treatments

Stressful exposure from the 2004 Indian Ocean Tsunami drives long-term changes in thyroid hormone physiology

This study finds that exposure to the 2004 Indian Ocean tsunami led to long-term reductions in free triiodothyronine levels and increased cardiometabolic risk 20 years later.

Public Cohort Analysis Identifies Thyroglobulin Variants as Hypothyroidism Risk Factors

The paper identifies thyroglobulin variants associated with hypothyroidism risk using biobank data and molecular characterization, revealing distinct pathophysiological mechanisms for different variants.

Thyroid hormone promotes fetal neurogenesis

This study shows thyroid hormone promotes fetal neurogenesis by inducing transcriptional changes in neural precursor cells, highlighting the importance of maternal thyroid hormone levels for brain development.

Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen

The paper investigates thyroglobulin phase separation in thyroid follicles, showing it forms storage depots and reveals a mechanism for hormone homeostasis.

Identification and determination of the urinary metabolite of iodotyrosine in vivo

This study identifies novel urinary metabolites of iodotyrosine in rats and confirms their elevation in Dehal1 knockout mice, suggesting IHPA as a potential biomarker for congenital hypothyroidism.

Genome-wide association studies of thyroid-related hormones, dysfunction, and autoimmunity among 85,421 Chinese pregnancies

This study performs GWAS on thyroid traits in Chinese pregnancies, identifying 176 genetic loci and linking thyroid function to pregnancy complications and later health outcomes.

Molecular Investigation of TSHR gene in Bangladeshi Congenital Hypothyroid patients

The paper identifies two TSHR gene mutations in congenital hypothyroid patients and evaluates their impact on drug binding and protein stability using computational methods.

A PATHWAY FOR T3 SIGNALING IN THE BRAIN TO IMPROVE THE VARIABLE EFFECTIVENESS OF THERAPY WITH L-T4

The paper identifies a neuronal pathway for T3 transport and signaling in the brain that explains variable L-T4 therapy effectiveness and resolves the paradox of T3 signaling amid high D3 activity.

Triac treatment prevents neurodevelopmental and locomotor impairments in thyroid hormone transporter Mct8/Oatp1c1 deficient mice

This study compares Triac and Ditpa in Mct8/Oatp1c1 deficient mice, finding Triac more effective in improving CNS development and locomotor function when administered early postnatally.

An atlas of thyroid hormone receptors target genes in mouse tissues

The paper compiles RNA-seq and ChIP-seq data to create an atlas of thyroid hormone receptor target genes in mouse tissues, revealing variations in target gene repertoires and factors influencing hormonal response.

A pivotal genetic program controlled by thyroid hormone during the maturation of GABAergic neurons in mice

This study identifies TR1-dependent gene regulation in GABAergic neurons during post-natal maturation, revealing a critical role for thyroid hormone in neurodevelopment.

Zebrafish duox mutations provide a model for human congenital hypothyroidism

This study shows that zebrafish duox mutants exhibit congenital hypothyroidism-like phenotypes, which can be rescued by T4 treatment, suggesting their utility as a model for human hypothyroidism.