Hearing, Cochlea, Tinnitus, Genetics

This study shows that mammalian octopus cells detect frequency sweep direction through synaptic sequence detection, not cross-channel coincidence, using in vivo recordings and a biophysical model.

This study shows that OHC-type II spiral ganglion afferents are critical for MOC efferent-mediated protection against noise-induced hearing loss in mice.

This study identifies interferon response gene upregulation in chicken supporting cells during sensory hair cell regeneration, linked to JAK/STAT signaling and the emergence of nascent hair cells.

This study shows that fusiform neurons in the mouse dorsal cochlear nucleus transition from a quiet to an active firing state after hearing onset, linked to increased persistent sodium current.

This study determines the cryo-EM structures of Prestin in multiple states, revealing its mechanism of area expansion and anion-binding site competition with salicylate.

This study uses scRNA-Seq to analyze zebrafish hair cell regeneration, identifying three sequential transcriptional modules involved in the process.

This study shows that Bmper promotes BMP signaling during semicircular canal development in zebrafish, leading to duct truncations in mutants.

This study shows that Oncomodulin prevents early progressive hearing loss in C57 and CBA mice by maintaining Ca2+ signaling in outer hair cells.

This study uses OCT to image the gerbil cochlea in vivo and postmortem, revealing changes in organ of Corti structures and fluid spaces during death.

This study shows that transient hearing loss during adolescence in gerbils causes long-lasting perceptual deficits due to altered auditory cortex processing, unlike adulthood hearing loss.

This study shows that activating ERBB2 signaling in cochlear supporting cells can partially reverse noise-induced hearing loss in mice.

The paper uses PSTR to predict adaptation and spontaneous firing rates in human auditory nerve fibers, showing agreement with single-unit recordings in animals.

This study shows that MOC efferent nerves also innervate cochlear supporting cells, modulating gap junctions and affecting OHC electromotility, which impacts hearing sensitivity and noise protection.

This study compares optogenetic and acoustic stimulation in guinea pigs, finding similar auditory responses to light and sound, with increased amplitude at higher light intensity.

This study investigates neural mechanisms of misophonia using fMRI, finding increased orbitofrontal connectivity and auditory-limbic pathway interactions in response to trigger sounds.

This paper develops an automated 3D inner ear modeling method to assess morphological similarities across species, finding mini pigs closely resemble humans in key structures.

This study demonstrates that antisense oligonucleotides targeting the c.151C>T mutation in COCH can reduce mutant transcript levels in transgenic cells, suggesting potential as a therapy for DFNA9.

This study investigates how contextual information affects aversive responses to sounds in individuals with misophonia, finding that the same sound can be perceived as more or less aversive based on context.

The paper models LSO neurons to replicate human sensitivity to envelope interaural time difference (ITDENV) across varying frequencies and modulation rates.

This study shows that loud noise exposure differentially affects firing properties of type A and B pyramidal cells in the auditory cortex of mice one week post-exposure.

This study shows that the MOC efferent system couples bilateral spontaneous activity in the developing auditory system, and its absence reduces auditory sensitivity at hearing onset.

The paper identifies pathogenic mutations in GJB2, GJB3, and GJB6 genes in an Indian cohort with non-syndromic sensorineural hearing loss and finds lower mutation rates compared to other populations.

The paper investigates the mechanisms of cochlear duct morphogenesis by analyzing cellular dynamics and signaling patterns during development.

The paper identifies and characterizes four lncRNAs in the mouse cochlea, showing their expression patterns and potential roles in inner ear function.

The paper studies a VGLUT3 variant causing DFNA25 deafness, showing fused stereocilia bundles and elongated synaptic ribbons in a mouse model.

The paper shows that the MOC reflex enhances speech understanding by gating auditory signals in degraded or noisy environments, with different brain regions engaged depending on the type of speech challenge.

The paper shows that simulated hearing loss in Mongolian gerbils leads to improved sensitivity at the notched frequency but not outside, and behavioral signs of phantom sounds.

The paper investigates age-related changes in auditory ribbon synapses of mice, finding increased synaptic transmission and potential compensation for synapse loss.

This study shows that LBH is essential for maintaining cochlear hair cells and stereocilia bundles, with its loss causing progressive hearing loss and OHC degeneration.

This study investigates the recovery of cochlear vibrations after reducing the endocochlear potential, finding that amplification requires both active electromotility and physical shifts in operating conditions.