Memory and Neural Mechanisms

Theta-paced stimulation of the thalamic nucleus reuniens entrains mPFC-HPC oscillations and facilitates the acquisition of extinction memories

This paper shows that theta-paced stimulation of the thalamic nucleus reuniens reduces freezing behavior and enhances extinction memory in rats.

Prefrontal default-mode network interactions with posterior hippocampus during exploration

This study investigates how interactions between the prefrontal default-mode network and posterior hippocampus influence exploration versus exploitation in a continuous reward environment using fMRI and reinforcement learning modeling.

Decoding hidden goal-directed navigational states and their neuronal representations using a novel labyrinth paradigm and probabilistic modeling framework

The paper introduces a labyrinth paradigm and probabilistic modeling framework to study hidden navigational states in mice, revealing impaired states in an Alzheimer's model and linking them to gamma oscillations in the PPC.

Early impairment in dentate pattern separation in a rodent model of temporal lobe epilepsy.

This study shows that early in temporal lobe epilepsy, the dentate gyrus has impaired pattern separation despite stable spatial coding, linking network changes to memory deficits.

Pre-existing and emergent cortical neuronal assembly sequences during learning

The paper investigates neuronal assembly sequences in the mouse orbitofrontal cortex during learning, finding pre-existing and emergent sequences involved in memory consolidation and retrieval.

The Primate Hippocampus Constructs a Temporal Scaffold Anchored to Behavioral Events

This study shows that the primate hippocampus segments experience into discrete events through abrupt population activity shifts, reflecting abstract task structure rather than specific sensory features.

Progressive remote memory decline coincides with parvalbumin interneuron hyperexcitability and enhanced inhibition of cortical engram cells in a mouse model of Alzheimer's disease

The paper shows that in a mouse model of Alzheimer's disease, remote memory decline with age is linked to increased inhibition of cortical engram cells by hyperexcitable parvalbumin interneurons.

Acetylcholine reflects uncertainty during hidden state inference

This study shows acetylcholine reflects uncertainty during hidden state inference in mice performing a probabilistic task.

Heterogeneous plasticity of amygdala interneurons in associative learning and extinction

This study investigates the plasticity of amygdala interneurons during fear learning and extinction, revealing complex single-cell and population-level responses.

Dynamic coupling between visual landmark processing in area 29e and parahippocampal path integration circuits of the rodent cortex

The paper investigates how area 29e in the rodent parahippocampus processes visual landmarks and interacts with spatial circuits during navigation, finding that 29e maintains landmark coupling while other regions decouple.

Hippocampal OLM interneurons regulate CA1 place cell plasticity and remapping

This study shows that OLM interneurons inhibit synaptic plasticity and influence place cell remapping by modulating dendritic calcium signaling in the hippocampus.

Sex Dependent Effects of Minocycline on Contextual Fear Memory

This study investigates how minocycline affects contextual fear memory in rats, showing sex-dependent differences in its impact on memory reconsolidation, extinction, and forgetting.

Slow-wave sleep alters the stability landscape of synaptic-weight space allowing life-long learning

This paper uses a biophysically realistic network model to show how sleep replay reorganizes synaptic-weight space to support both old and new memories.

Competition between memories for reactivation as a mechanism for long-delay credit assignment

The paper proposes a neural mechanism for long-delay credit assignment through memory reactivation competition in a spiking neural network model.

Stability through plasticity: Finding robust memories through representational drift

This paper shows that representational drift uncovers noise-robust neural representations that are difficult to learn but beneficial for memory stability.

Bayesian multilevel modeling of group and participant level effect sizes: Stronger inter-individual differences in pupil dilation compared to EEG alpha power during aversive conditioning

This study compares pupil dilation and EEG alpha power during aversive conditioning, finding greater inter-individual variability in pupil dilation effects at the participant level.

Fronto-Hippocampal Synchronization in Rapid Spatial Learning in Humans

This study investigates how OFC gamma oscillations and hippocampal ripples interact during rapid spatial learning in humans using iEEG recordings.

Phase-Specific Hippocampal and Cortical Medial Temporal Lobe Involvement in Allocentric Working Memory

This study uses fMRI to examine phase-specific involvement of hippocampal and cortical MTL regions in allocentric working memory, finding distinct patterns across encoding, delay, and test phases.

Too little and too much: balanced hippocampal, but not medial prefrontal, neural activity is required for intact novel object recognition in rats

This study investigates the role of GABAergic inhibition in the hippocampus and prefrontal cortex on novel object recognition in rats, finding that hippocampal inhibition is critical while prefrontal inhibition is not.

Single-cell resolution spatial transcriptomic signature of the retrosplenial cortex during memory consolidation

This study identifies the transcriptional changes in the retrosplenial cortex during spatial memory consolidation using spatial transcriptomics and shows the role of excitatory neurons in memory formation.

Reactivating aversive memories in humans: An EEG and Microstates study of post-retrieval processes

This study investigates neural correlates of post-retrieval processes of implicit threat memory using EEG and microstate analysis in humans.

Sickness engrams modulate anticipatory immune responses

This study shows that sickness experiences are encoded as brain engrams that, when reactivated, trigger metabolic and immune responses similar to natural sickness.

Similar processing of novelty in rat dorsal and intermediate CA1 despite differences in spatial tuning

The paper compares how CA1 cells in dorsal and intermediate hippocampal regions process spatial and social/odor novelty, finding similar responses despite differences in spatial tuning.

Retrosplenial cortex enables context-dependent goal-directed sensorimotor transformation

This study identifies the retrosplenial cortex's role in context-dependent sensorimotor transformation through behavioral tasks and optogenetic inactivation in mice.

A semantotopic map in human hippocampus

The paper maps semantic organization in the human hippocampus, finding semantotopic patterns and multiscale semantic similarity along the mediolateral axis.

The hippocampus as an epistemic forager: When curiosity and reward jointly steer exploration and hippocampal replay

This paper introduces the Epistemic Replay Algorithm (ERA) to explain hippocampal replay by integrating curiosity and reward, showing it better accounts for replay properties than non-curious models.

Hippocampus facilitates reinforcement learning under partial observability

This study uses deep reinforcement learning to show that hippocampal circuitry enables learning in partially observable environments, aligning with animal behavior and experimental data.

Cell type and locus-specific epigenetic editing of memory expression

This study uses CRISPR-based epigenetic editing in adult mouse brains to show that site-specific epigenetic changes in learning-related neurons are causally involved in memory expression.

The Intermediate CA1 and CA3 Subfields of the Hippocampus Differentially Encode Social Recognition

This study uses calcium imaging to show that iCA3 neurons better distinguish novel vs. familiar conspecifics, while iCA1 neurons encode spatial position during social recognition.

Dentate spikes comprise a continuum of relative input strength from the lateral and medial entorhinal cortex.

The paper identifies a third type of dentate spike (DS3) that represents a continuous distribution of input strength from lateral and medial entorhinal cortex, challenging the traditional bimodal classification.