Memory and Neural Mechanisms

Locus coeruleus-hippocampal pathway activation promotes spatial memory updating during reversal learning

This study shows that activating the locus coeruleus-hippocampal pathway improves spatial memory updating during reversal learning but not initial spatial learning.

Granule cells reorient cortical trajectories to separate contexts

In mice learning two tasks, cerebellar granule cells kept the low-rank geometry of premotor cortical output within each task but rotated their population trajectories apart between tasks, while cortex generalized.

Pharmacological blockade of opioid receptors in the ventrolateral periaqueductal gray does not affect avoidance acquisition or performance in rats

This study tests if opioid receptor blockade in the vlPAG affects avoidance learning in rats, finding no significant impairment in acquisition or performance.

HDAC3 inhibitor RGFP966 enhances memory persistence in a biphasic manner and modulates NF-kB nuclear localization

This study shows that HDAC3 inhibition with RGFP966 enhances memory persistence in mice at two time points and increases NF-kB nuclear localization during memory consolidation.

Transcription-specific synaptic plasticity mediates engram computations

The paper shows that transcription-specific synaptic plasticity in distinct neuronal ensembles drives memory computations in mice.

Prefrontal cortex glucocorticoid receptors during fear memory consolidation shift the balance between salience and default-mode networks at retrieval in rats

This study shows that blocking glucocorticoid receptors in the dmPFC of rats after fear conditioning reduces memory specificity and shifts retrieval networks from salience to default-mode configurations.

The geometry of knowledge in the hippocampal-prefrontal system

The paper shows that neural manifolds in the medial prefrontal cortex and hippocampus represent task variables as smooth gradients in low-dimensional space, with time-aligned geometry across brain areas.

The hippocampus and cortical memory networks have an inflection point in middle childhood

The paper examines age-related changes in hippocampal function and connectivity in children and adults, finding an inflection point around 7 years of age.

Criterion-selective neurons in the human medial frontal cortex track decision thresholds during memory-based decision making

The paper identifies two types of neurons in the medial frontal cortex that track decision criteria and memory strength during memory-based decision making.

Systemic diazepam alters local hippocampal CA1 circuits and differentially affects entorhinal and CA3 inputs

This study examines how systemic diazepam affects hippocampal circuit function in rats during behavior, finding altered inhibition, theta and low-gamma power, and reduced spatial precision.

Deleting learning-induced dendritic spines disrupts the memory they encode

The paper shows that deleting newly formed dendritic spines after learning disrupts memory formation, but not existing memories or new learning.

Working memory retention by medial entorhinal cortex low-dimensional neural dynamics

This study investigates how the medial entorhinal cortex (mEC) maintains information during working memory, finding that low-dimensional neural dynamics, not limited to grid cells, support memory retention through recurring activity patterns.

CA3 sparsity stabilises high-connectivity recurrent autoassociation: complementary binary and spiking computational modes in a DG->CA3 model

This paper investigates how CA3 recurrent connectivity affects autoassociation in a DG->CA3 model, finding that sparsity stabilizes high-connectivity networks and that binary and spiking CA3 types have opposing failure modes.

Coordinated behavioural and neural variability in hippocampal reward coding

The paper examines correlations between behavioural variability and neural coding in the hippocampus during reward-based navigation in mice.

Distinct prefrontal-amygdala connectivity drives consolidated fear memories

This study identifies a specific prefrontal-amygdala circuit that is essential for consolidated fear memories, showing that post-learning engagement of a distinct sub-circuit is required.

Claustral pathway coordinates distributed cortical dynamics with hippocampal output during sleep to promote memory consolidation

The paper identifies a claustral neuron population that coordinates cortical and hippocampal activity during sleep to enhance memory consolidation.

Stochastic resonance in the impact of afferent sensory noise on grid-patterned firing and path integration in a continuous attractor network

This study investigates how sensory noise affects grid-patterned firing and path integration in a continuous attractor network, finding that low levels of noise can enhance performance through stochastic resonance.

Electrophysiological dissociation of human posterior cingulate cortex contributions to value- and memory-based decision-making

This study identifies a functional dissociation in human posterior cingulate cortex, showing dorsal PCC integrates value and memory-based decisions while ventral PCC does not.

Nucleus reuniens is organised as parallel circuits rather than a prefrontal-hippocampal relay

The paper challenges the idea that the nucleus reuniens acts as a relay between prefrontal cortex and hippocampus, showing instead that it contains distinct circuits with separate projections.

Sex differences in diverse conditioned fear behaviors following systemic naloxone administration

This study examines sex differences in fear behaviors after naloxone administration in rats, finding sex-specific effects on freezing, shock response, and ultrasonic vocalizations.

GO, NO-GO: A SENSITIVE PERIOD FOR DEVELOPING SEX-SPECIFIC VISUALLY-GUIDED PREY PURSUIT-PREDATOR AVOIDANCE TRADE-OFF STRATEGIES

The paper investigates how adolescence shapes sex-specific strategies for balancing prey pursuit and predator avoidance in mice.

Hippocampal-midbrain interactions link encoding-related pupil response to memory success

This study links encoding-related pupil responses to memory success by showing their correlation with hippocampal-midbrain interactions during memory formation.

Circuit-specific reorganization of hippocampal-entorhinal-prefrontal subnetworks supports memory recall across the lifespan

The paper examines how memory recall circuits reorganize across the lifespan in mice, showing a shift from hippocampal to broader cortical networks involving the entorhinal cortex.

Oxytocin receptor Gαi signaling drives valence reassignment to facilitate reversal of social trauma-induced avoidance

The paper identifies a specific neural mechanism involving oxytocin receptor Gαi signaling in the caudal lateral septum that facilitates the reversal of social trauma-induced avoidance.

The lattice scales of grid-cell activity

The paper reanalyzes grid-cell datasets and finds that scale ratios follow a geometric progression, refuting a developmental theory and supporting an efficient-coding explanation.

Rats use darting as a strategy to navigate between reward and safety during platform-mediated active avoidance under different social contexts.

This study examines darting behavior in rats during the PMA task, finding that social context influences darting frequency, speed, and location, suggesting it is a learned navigation strategy.

Reusable modular architecture enables flexible cognitive operations in the mouse brain and artificial recurrent networks

This study shows that mice and artificial neural networks reuse modular neuronal subspaces to perform complex cognitive tasks.

Distinct cortical spatial representations learned along disparate visual pathways

The paper builds a learning model to show how diverse spatial properties in the postrhinal cortex emerge from visual input processing through the superior colliculus pathway.

Topographic CA1 input shapes subicular spatial coding

The paper shows that precise CA1 input topography shapes subicular spatial coding and network dynamics, while preserving single-cell tuning and impairing boundary vector coding and long-term stability.

Distinct Working Memory for Near and Far in a T-Maze Delayed Alternation Task: Evidence for Dual-Process Dynamics in Hippocampal-Prefrontal Coordination

The paper examines working memory differences in rats at varying task distances using electrophysiological recordings, finding distinct dynamics in prefrontal-hippocampal interactions.