Memory and Neural Mechanisms

A computational model of the two dentate gyrus blades

The paper introduces a computational model of the two dentate gyrus blades, showing how they support pattern separation and integration through distinct architectures and mechanisms.

Structured experience shapes strategy learning and neural dynamics in the medial entorhinal cortex

This study shows that structured early training improves generalization and flexible strategy learning in both mice and recurrent neural networks.

Neural correlates of place learning in the cane toad, Rhinella marina

This study investigates place and cue learning in cane toads using a maze and brain activity visualization, showing distinct neural activity patterns for place learning in the dorsal and lateral pallium.

Brain injury degrades the precision of hippocampal spatial representations

This study shows that traumatic brain injury (TBI) reorganizes hippocampal spatial representations by increasing spatially unresponsive neurons and broadening place fields, despite preserved overall CA1 activity.

Sensory cortical disinhibition is required for long-term fear memory in humans

This study uses HD-tACS and neural decoding to show that sensory cortical disinhibition is necessary for long-term fear memory in humans.

Brainwide representation of navigation

The paper shows spatial position is represented across the brain in mice, with the hippocampal formation showing slightly more uniform representation than other regions.

Hippocampal representations of possible futures predict motor output in the superior colliculus

The paper shows that hippocampal representations of possible future paths predict motor output in the superior colliculus during navigation.

Anxiety-Related Traits Are Associated with Subjective Biases but not Altered Threat-Safety Discrimination

This study examines how anxiety-related traits are linked to subjective fear responses but not to altered threat-safety discrimination across different phases of fear conditioning.

Amygdalostriatal transition zone neurons encode sustained cue responses to guide defensive behaviors

The paper identifies the amygdalostriatal transition zone (ASt) as a critical structure for encoding sustained cue responses that guide defensive behaviors.

Habit learning shapes activity dynamics in the central nucleus of the amygdala

This study investigates how CeA neurons encode behavioral features during habit formation in rats performing a maze task, finding increased cFos expression and specific outcome-related activity.

Environmental complexity reveals memory-guided search as the locus of learning in prey capture

This study shows that mice improve prey capture by reorganizing search strategies in complex environments, using memory and learned object values.

Entorhinal grid coding as a functional link between tau accumulation and episodic memory in human aging

The paper investigates how tau accumulation in the entorhinal cortex affects episodic memory by analyzing grid-cell-like signals in older adults using MRI and tau PET.

Predictability and controllability shape aversive learning and stress responses through independent computational mechanisms

This study investigates how predictability and controllability affect aversive learning and stress responses through distinct computational mechanisms.

Decoding medial entorhinal cortical dynamics produces planning-like alternations in hippocampal theta sequences

The paper shows that left-right alternation in hippocampal theta sequences is driven by medial entorhinal cortex dynamics, not intentional planning.

Phylogeny of cortical-hippocampal projections reveals selective elimination of input from sensory regions

The paper examines cross-species differences in cortical-hippocampal projections across six mammals, finding that direct unimodal input from sensory regions is selectively eliminated as brain size increases.

Obesogenic Diet Impairs Social Memory Through Alterations of Hippocampal CA2 Excitability and Oxytocin Signaling

This study shows that an obesogenic diet impairs social memory in mice by altering hippocampal CA2 excitability and oxytocin signaling, with specific effects on endocannabinoid plasticity and social novelty discrimination.

Learning a threat converges on the circuit processing innate threat

The paper shows that innate and learned threats in mice use similar circuit mechanisms but differ in how access to these mechanisms is achieved.

Asymmetrical modulation of fear expression via GABAB receptors in the mouse medial habenula

This study shows that the left medial habenula (MHb) in mice has functional asymmetry in fear expression, mediated by GABAB receptors, and this asymmetry is influenced by internal organ laterality.

Transcriptomic characteristics along the longitudinal axis of the hippocampus and medial entorhinal cortex across species

The paper uses spatial transcriptomics and single-nucleus RNA sequencing to analyze dorsoventral molecular organization in hippocampus and medial entorhinal cortex across five species, identifying conserved and species-specific patterns.

Subicular spatial codes arise from predictive mapping

This study shows that subicular neurons encode predictive spatial representations by integrating behavioral biases into the successor representation framework, explaining their diverse activity patterns.

Structural generalization and continual learning enabled by factorized entorhinal-hippocampal memory and entorhinal-parietal action circuits

The paper develops a computational model of memory and learning in the brain that enables generalization and continual learning through factorized entorhinal-hippocampal and entorhinal-parietal circuits.

Locomotion-invariant prefrontal-thalamic goal states organize spatially aligned episode-specific hippocampal maps

The paper shows that prefrontal-thalamic pathways encode goal states in a way that allows hippocampal maps to remain spatially aligned across different navigation episodes.

Contextual Inference Drives Motor Memory Protection and Disruption

The paper investigates how memory reactivation influences motor memory interference, finding that reactivating a memory before interference protects it from disruption.

Hippocampal CA2 Inhibition Disrupts Prefrontal and Thalamic Connectivity

This study shows that inhibiting hippocampal CA2 neurons disrupts prefrontal and thalamic connectivity and impairs social behavior.

The pERKs of Temporal Order Memory in mice

This study investigates the molecular mechanisms of temporal order memory in mice, finding dynamic ERK2-MKP3 signaling in the prefrontal cortex and revealing behavioral features of memory retrieval.

Neuronal selectivity and geometric alignment in the human hippocampus support abstract generalization

This study shows that category-selective neurons in the human hippocampus enhance cross-context generalization by aligning population geometry across contexts.

Joint experience-dependent representations of odors and temporal context in the zebrafish homolog of piriform cortex

This study shows that zebrafish pDp represents odor and temporal information together, with experience improving how well this information is organized and generalized.

A theory-guided model maps four recurrent modes of fear-goal arbitration across learning and relapse in rats

The paper uses a theory-guided model to identify four modes of fear-goal arbitration in rats during learning and relapse, showing fear reduction without full functional recovery.

Heterogeneous single-cell dynamics support stable population codes for objects in the mouse anterior cingulate cortex

The paper shows that the mouse anterior cingulate cortex uses dynamic single-cell activity to maintain stable population codes for object locations across repeated experiences.

Distinct and overlapping correlates of fear acquisition and extinction across different neuroimaging modalities

The paper examines brain correlates of fear acquisition and extinction using multimodal neuroimaging data and identifies overlapping and distinct brain regions involved in these processes.