Memory and Neural Mechanisms

A distributed pallial circuit links sensory and bodily representations to aversive motivational value in the goldfish dorsomedial pallium

This paper identifies a distributed functional organization in the goldfish dorsomedial pallium, showing distinct domains that process sensory inputs and generate aversive motivational value through interconnected circuits.

The brain architecture of punishment learning

This study maps how punishment learning reorganizes brain networks across scales using combined whole-brain analysis and spatial transcriptomics.

Safety learning produces rapid fear suppression and distinct amygdala-prefrontal engagement

This study compares fear and safety learning in rats, finding distinct neural activation patterns and behavioral outcomes, with safety learning promoting faster fear suppression.

Functional specialization of mPFC-BLA and mPFC-NAc pathways in affective state representation

The paper identifies distinct functional roles of mPFC-BLA and mPFC-NAc pathways in representing anxiety-like and positive valenced behavioral states through neural activity patterns.

Habit and the hippocampus: Model-based spatial representations without outcome-sensitive control

This study shows that hippocampal-dependent navigation can be insensitive to outcome revaluation, suggesting it supports habitual-like behavior in a spatial task.

Pathway-specific short-term synaptic dynamics and lateral inhibition shape frequency-dependent input integration and population-level pattern separation in the dentate gyrus

This paper uses computational models to show how pathway-specific synaptic dynamics and lateral inhibition shape frequency-dependent input integration and noise-robust pattern separation in the dentate gyrus.

Activation of the medial entorhinal cortex drives memory-guided navigation behavior

This study shows that spatially consistent activation of the medial entorhinal cortex (MEC) biases reward-predictive behaviors and supports memory-guided navigation.

Distinct Working Memory for Near and Far in a T-Maze Delayed Alternation Task

This study examines how delay duration and task distance affect working memory in rats using a T-maze task, finding that both factors independently influence performance.

Reciprocal feedback inhibition and divergent intrinsic firing properties between behaviorally defined classes of neurons in the mouse ventromedial hypothalamus

This study identifies reciprocal feedback inhibition and distinct intrinsic firing properties between two neuron classes in the mouse ventromedial hypothalamus involved in defensive behaviors.

Generative replay across hippocampal-neocortical circuits

The paper shows that generative replay occurs in primary visual cortex during sleep, influenced by hippocampal activity, suggesting a mechanism for building hierarchical generative models for flexible behavior.

An update on the model of connectivity of the hippocampal formation (I): the perforant pathway to the dentate gyrus

The paper updates a model of connectivity from the entorhinal cortex to the dentate gyrus, revealing higher divergence and synaptic complexity than previously described.

Hippocampal-cortical coupling dynamics drive system consolidation of remote memory

This study investigates how hippocampal-cortical coupling dynamics during learning and sleep contribute to the system consolidation of remote memory.

Generalisation between motor and declarative memory sequences: A conceptual replication of Mosha & Robertson (2016)

This study replicates Mosha and Robertson's (2016) findings on cross-domain memory generalisation but finds no performance benefit from shared ordinal structure between declarative and motor sequence tasks.

Subicular Plateaus Signal Reward Locations during Goal-Directed Behavior

This study identifies subicular plateaus as a cellular substrate of hippocampal bursting output during goal-directed learning, showing that membrane potential state organizes their behavioral associations.

A Parallelized, Automated System for Higher-Throughput Spatial Navigation Testing of Rats

This paper describes a parallelized maze system for automated spatial navigation testing in rats, improving throughput and reducing experimenter variability.

Spontaneous emergence of context-dependent statistical learning in humans and neural networks

This study shows humans and neural networks can learn context-dependent statistical patterns even with changing, unsignaled contexts, and identifies distributed representations as key to preventing interference.

Mild and Reversible Proprioception Perturbation Suggests Causal Biomechanics for Memory-Dependent Spatial Behavior in Mice

This study uses optogenetics to reversibly perturb proprioception in mice during spatial tasks, showing its role in path integration and spatial memory.

Intratelencephalic neurons in the medial prefrontal cortex mediate the acquisition of goal-directed actions.

The paper identifies mPFC intratelencephalic neurons as critical for goal-directed learning through chemogenetic inhibition and synaptic plasticity analysis.

A selective cortico-limbic network organizes behavior during reward seeking under threat

This study identifies a selective cortico-limbic network involved in resolving motivational conflict during reward seeking under threat by inactivating brain regions in rats.

A Neurotensin Brake on Exploratory Drive under Persistent Threat

This study identifies a neural circuit in mice linking neurotensin in the lateral septum to avoidance behaviors under chronic stress.

Memory encoding reprograms neuronal transcriptional responses via durable chromatin remodeling

This study shows that chromatin remodeling in engram neurons during memory storage alters their transcriptional responses to future experiences, dampening further information storage.

Synaptic engram underlies memory

The paper shows that synaptic depression between memory-encoding engram cells impairs memory, demonstrating that synaptic plasticity between these cells causally supports memory.

Hippocampal theta distinguishes between memory-guided and exploratory saccades in humans

This study shows that hippocampal theta oscillations distinguish memory-guided from exploratory eye movements in humans through power and coherence changes.

Predictive abstract task representations support few-shot learning in the rat brain

This study shows that rats can rapidly adapt to new task contingencies using abstract representations in the orbitofrontal cortex, supporting few-shot learning.

Experience reorganizes content-specific memory traces in macaques

The paper shows that memory traces in macaques become more stable over time, with older memories showing less drift and stronger sleep reactivation.

Excitatory cholecystokinin neurons in CA3 area regulate the navigation learning and neuroplasticity

This study shows that excitatory CCK neurons in the CA3 area regulate hippocampal-dependent navigation learning and neuroplasticity through their projections to CA1 pyramidal neurons.

Beyond Temporary Scaffolding: Persistent Hippocampal Engagement and Brain-Wide Network Reorganization in Remote Memory Consolidation

This paper challenges the standard model of memory consolidation by showing persistent hippocampal engagement and brain-wide network reorganization during remote memory retrieval.

Selective enhancement of fronto-temporal mechanisms for adaptive memory

This study uses transcranial ultrasound stimulation to enhance memory performance in macaques by targeting specific fronto-temporal brain regions.

Structured navigation in a goal-directed task reveals flexible spatial coding

The paper introduces a platform for studying navigation in rats that combines free movement with controlled stimuli and rewards, revealing spatial coding in the medial entorhinal cortex.

Remembering the "When": Hebbian Memory Models for the Time of Past Events

The paper develops Hebbian memory models to simulate how neural mechanisms enable remembering the time of past events, showing multiple biologically plausible implementations.