Wound Healing and Treatments

This paper develops a hydrogel patch that releases oxygen and buffers acidity in oral wound models, improving cell viability and pH balance.

This study shows that Schwann cell dysfunction contributes to diabetic wound healing impairment and that oncostatin M treatment partially improves wound repair in diabetic mice.

This study shows that exercise-induced sweat promotes wound healing in diabetic foot ulcers by enhancing re-epithelialization, collagen deposition, and angiogenesis in a mouse model.

This paper introduces a bioelectronic dressing that senses and treats chronic wounds through real-time biochemical monitoring, drug release, and electrical stimulation.

This study compares the effects of ultra-wideband low-intensity mechanical waves (UMUS) and low-intensity pulsed ultrasound (LIPUS) on wound healing in a rat amputation model, finding UMUS more effective in reducing wound size and promoting tissue repair.

The paper evaluates the in vivo efficacy of VeritaCell-derived autologous skin cell suspensions in a rat wound model, showing accelerated healing and reduced scarring.

This study shows that different modes of macrophage cell death affect wound healing outcomes, with necroptosis impairing repair and apoptosis promoting better tissue recovery.

This study identifies osteopontin (OPN) as a critical mediator of tissue repair during Staphylococcus aureus skin infections by analyzing single-cell transcriptomics in a murine model.

This study uses proteomics to show that snail slime induces redox modulation, controlled apoptosis, and enhanced migration in human dermal fibroblasts, supporting its regenerative potential.

This study shows that increasing SPARC expression in mesenchymal stem cells enhances their secretome's ability to promote skin regeneration and wound healing.

This study evaluates bioabsorbable magnesium wires in a murine wound model, showing improved granulation tissue, reduced inflammation, and enhanced neovascularization.

The paper defines the role of smooth muscle cells in ECM remodeling during human wound healing and identifies TIMP1 as a key factor in effective repair.

This study shows that a regenerative stem cell-derived matrix improves diabetic wound healing by enhancing granulation tissue remodeling, nerve formation, and vascular maturation.

This study shows immune checkpoint inhibitors enhance type 2 immunity and regeneration in ECM-treated wounds by promoting Treg/TH2 plasticity and pro-regenerative macrophages.

The paper presents OWHA, a 4D multimodal atlas of wound healing in mice, revealing a conserved Basal IV/SEMA3C circuit that coordinates repair, and shows its disruption in diabetic wounds.

The paper shows that actin remodeling during wound healing inactivates ERK1/2, unmasking DNMT3a's nuclear localization signal and enabling its nuclear translocation to regulate epigenetic reprogramming.

This study shows that relaxin-2 reduces fibrosis and promotes regenerative healing by inhibiting TGF-b1-driven ECM deposition in both in vitro and in vivo models.

This study shows that mitophagy enhances WNT5A/Ca2+ signaling to promote fibroblast migration and wound healing, with Urolithin A treatment improving healing outcomes.

This study identifies mitophagy's role in enhancing keratinocyte migration during wound healing via ANGPTL4 and metabolic reprogramming.

The paper integrates microbiome, metabolome, and clinical data to predict chronic wound healing with 94% accuracy using DIABLO.

This study shows trehalose enhances keratinocyte migration and wound closure via the VEGF/JNK/PI3K pathway in vitro.

This study evaluates a vitamin C-loaded hyaluronic acid/collagen scaffold for enhanced wound healing in rat models, showing improved fibroblast activity and reduced inflammation.

This study shows that GPR132b in zebrafish affects wound healing and infection resistance by modulating macrophage activity and lipid signaling pathways.

This study develops a 3D multicellular in vitro model to assess ADSC-EVs' impact on vascularisation and wound healing, finding enhanced vessel formation and macrophage co-localisation with EV treatment.

This study shows that xylazine and fentanyl co-administration in mice delays wound healing, while neither drug alone does so at tested doses.

This study shows that γδ T cells interact with NPY1R+ neurons in skin during wound repair, and obesity impairs these interactions, suggesting a neuroimmune disruption in wound healing.

This study shows that topical 4-aminopyridine delivered via a gel formulation accelerates burn wound healing by enhancing re-epithelialization, hair follicle regeneration, and fibroblast to myofibroblast transformation.

The paper develops a collagen-GAG scaffold with ultrasound-triggered sequential release of AAV vectors to promote chronic wound healing.

This study identifies reparative fibroblasts in aged mice that enhance scarless wound healing through EREG signaling, showing their role in regenerative outcomes.

This study shows ROS inhibit myosin phosphorylation to counteract wound contraction, delay closure, and impair regrowth, while chronic ROS depletion alters tissue stiffness and impairs healing.