Olfactory and Sensory Function Studies

Bilateral alignment of receptive fields in the olfactory cortex

The paper shows that odor responses in the olfactory cortex of mice are highly matched between hemispheres, allowing decoding of odor identity and laterality through Hebbian plasticity.

Data Science in Olfaction

The paper presents a data science approach to olfaction, using machine learning to classify neural responses to odors in mice and proposes a standard dataset for olfactory research.

Hypothalamic representation of the imminence of predator threat detected by the vomeronasal organ in mice

The paper shows that fresh cat saliva activates distinct VMH neurons in mice, correlating with freezing behavior intensity, indicating a time-sensitive olfactory circuit for predator threat detection.

Human Olfactory Perception is Sensitive to Temporal Information within a Single Sniff

This study shows human olfaction can distinguish odorants based on their temporal order within a single sniff, with performance improving as the onset asynchrony increases.

Neuroanatomy of the Accessory Olfactory Bulb in the Fossorial Water Vole

This study characterizes the morphological and neurochemical organization of the accessory olfactory bulb in the fossorial water vole, revealing distinct structural features and functional distinctions from the main olfactory bulb.

Regional deficits in endogenous regeneration of olfactory sensory neuron axons in the mouse olfactory bulb

This study shows that after olfactory sensory neuron ablation, axon reinnervation of the mouse olfactory bulb is regionally impaired, with the dorsomedial region showing the most deficit.

Mammalian chemosensory bile acid detection supports species and gut microbiome evaluation

The paper identifies taurine-conjugated bile acids (tauro-BAs) as novel vomeronasal ligands that activate rodent accessory olfactory system neurons and vary in feces across species and gut microbiomes.

Reconstruction of functional olfactory sensory tissue from embryonic nasal stem cells

This study creates OE organoids from mouse embryonic stem cells that mimic the structure and molecular features of olfactory epithelium, including single OR expression and axon guidance gene patterns.

Different behaviourally relevant stimuli evoke different forms of adaptation in the olfactory system

The paper investigates how different behaviorally relevant stimuli induce distinct adaptation forms in the zebrafish olfactory system, finding varied responses to food and alarm substances.

Cholinergic feedback for context-specific modulation of sensory representations

This study shows that cholinergic feedback axons in the olfactory bulb shift their activity from movement-correlated to odor-aligned responses during odor discrimination tasks in mice, enhancing task performance.

Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism.

This study shows that GHSRs in the olfactory bulb link hunger to olfactory sensitivity, affecting food-seeking and metabolism in mice.

Vasopressin differentially modulates the excitability of rat olfactory bulb neuron subtypes

This study investigates how vasopressin modulates excitability in different neuron subtypes of the rat olfactory bulb, revealing subtype-specific effects on synaptic responses and calcium influx.

Fast-spiking interneuron detonation drives high-fidelity inhibition in the olfactory bulb

The paper investigates how fast-spiking interneurons in the olfactory bulb provide high-fidelity inhibition through synaptic detonation mechanisms.

The Ca2+-activated Cl- channel TMEM16B shapes the response time course of olfactory sensory neurons

This study shows that TMEM16B, a Ca2+-activated Cl- channel, influences the response kinetics and action potential generation of olfactory sensory neurons, while the CNG channel primarily determines response delay and adaptation.

Main compounds in sweat, such as squalene and fatty acids, should be promising pheromone components for humans

The paper identifies squalene and fatty acids as potential pheromone components in human sweat through GC-MS analysis and speculates on their role in transmitting olfactory information.

Development of a noninvasive olfactory stimulation fMRI system in marmosets

The paper develops an olfactory stimulation fMRI system in marmosets to study olfactory pathway activity and its potential link to neurodegenerative diseases.

Parvalbumin interneuron ErbB4 controls ongoing network oscillations and olfactory behaviours in mice

This study shows that ErbB4 in PV interneurons regulates inhibitory circuits and ongoing oscillations in the olfactory bulb, affecting olfactory discrimination and dishabituation in mice.

Olfactory cortical outputs recruit and shape distinct brain-wide spatiotemporal networks

This study investigates the spatiotemporal properties of brain-wide neural interactions in olfactory networks using optogenetics, fMRI, and computational modeling, revealing distinct roles of olfactory bulb and cortical outputs.

Ex vivo functional characterization of mouse olfactory bulb projection neurons reveals a heterogenous continuum

The paper characterizes mouse olfactory bulb projection neurons ex vivo, finding a functional continuum rather than distinct mitral/tufted cell types.

Synaptic connectivity and electrophysiological properties of the nucleus of the lateral olfactory tract

This study characterizes the synaptic connectivity and electrophysiological properties of the nucleus of the lateral olfactory tract (NLOT) in mice, revealing its role in integrating olfactory and amygdalar inputs to assign emotional value to odors.

Acquisition of non-olfactory encoding improves odour discrimination in olfactory cortex

This study shows that learning enhances odour discrimination in the piriform cortex by integrating non-olfactory contextual information into neuronal responses.

Control of innate olfactory valence by segregated cortical amygdala circuits

The paper identifies a topographic organization in the posterolateral cortical amygdala (plCoA) that controls innate olfactory attraction and aversion through distinct cell types and projections.

Reduction in olfactory ability in aging Mitf mutant mice without neurodegeneration

This study shows that aged Mitf mutant mice have reduced olfactory ability without neurodegeneration, but increased potassium channel gene expression suggests compensatory mechanisms.

The Incisive Duct as a Pathway for Early Vomeronasal Communication in Neonatal Dogs

This study confirms functional communication between the incisive duct and vomeronasal duct in neonatal dogs through histological analysis.

Distinct information conveyed to the olfactory bulb by feedforward input from the nose and feedback from the cortex

The paper investigates how feedforward and feedback inputs to the olfactory bulb encode odor information, finding that feedback provides sparse, decorrelated representations of complex odors.

Following the p63/Keratin5 Basal Cells in the Sensory and Non-sensory Epithelia of The Vomeronasal Organ

The paper identifies p63/Keratin5-positive basal cells in the vomeronasal organ's sensory and non-sensory epithelia, showing their role in self-renewal and differentiation into apical cells.

A mechanosensory feedback that uncouples external and self-generated sensory responses in the olfactory cortex

The paper shows that in the olfactory cortex, mechanosensory feedback decouples odor concentration representation from inhalation speed, ensuring sniff-invariant odor encoding.

Robust encoding of sub-sniff temporal information in the mouse olfactory bulb

The paper investigates how temporal information from odour stimuli is encoded in mouse olfactory bulb neurons, finding a consistent temporal resolution and separable encoding of odour quality and dynamics.

Distinct subpopulations of ventral pallidal cholinergic neurons encode valence of olfactory stimuli

The paper identifies two distinct subpopulations of VP cholinergic neurons that encode valence of olfactory stimuli and differentially regulate approach and avoidance behaviors.

Behavioral discrimination and olfactory bulb encoding of odor plume intermittency

This study shows mice can discriminate odor plume intermittency and the olfactory bulb encodes this property, with sniffing behavior influencing both performance and neural representation.