Olfactory and Sensory Function Studies

Metabolic state modulates neural processing of odors in the human olfactory bulb

This study shows that metabolic state affects odor processing in the human olfactory bulb, with higher gamma power observed during hunger compared to satiety.

The spiking output of the mouse olfactory bulb encodes large-scale temporal features of natural odor environments

This study investigates how mouse olfactory bulb spiking activity encodes temporal features of natural odor plumes, finding that population-level activity captures plume onset, offset, and presence/absence, while individual cells encode only limited features.

Molecular, Cellular, and Developmental Organization of the Mouse Vomeronasal Organ at Single Cell Resolution

This study generates single-cell transcriptomic atlases of the mouse vomeronasal organ, revealing new cell types, lineage relationships, and molecular mechanisms of receptor specification.

Sniffing can be initiated by the actions of dopamine on ventral striatum neurons

This study shows dopamine in the ventral striatum initiates sniffing by modulating respiratory rate and neuronal activity.

Inflammation-related pathology in the olfactory epithelium: its impact on the olfactory system in psychotic disorders

This study investigates how inflammation in the olfactory epithelium affects the olfactory bulb in schizophrenia and related disorders, finding correlations between immune-related gene expression and OB volume reduction.

Long-Run Olfactory Enrichment Promotes Non-Olfactory Cognition, Noradrenergic Plasticity And Remodeling Of Brain Functional Connectivity In Aged Mice

This study shows that lifelong olfactory enrichment in mice improves cognitive performance and brain connectivity, linked to noradrenergic plasticity and network remodeling in aging.

Foxj1 controls olfactory ciliogenesis and differentiation program of the olfactory sensory neurons

This study identifies Foxj1's role in regulating olfactory cilia formation and OSN differentiation in zebrafish and mice.

Single cell transcriptomics of vomeronasal neuroepithelium reveals a differential endoplasmic reticulum environment amongst neuronal subtypes

The paper performs single-cell transcriptomics on mouse vomeronasal sensory epithelium to identify cell types and functional differences, finding distinct ER environments in neuronal subtypes.

Monorhinal and Birhinal Odor Processing in Humans: an fMRI investigation

This study uses fMRI to investigate whether nostril-specific odor stimulation produces asymmetrical activation in olfactory cortical structures in humans.

Do Fossorial Water Voles have a Functional Vomeronasal Organ? A Histological and Immunohistochemical Study

This study confirms the presence of a functional vomeronasal system in fossorial water voles through histological and immunohistochemical analysis.

Neural responses to social cues in the accessory olfactory bulb are altered by context and experience.

This study examines how context and experience influence neural activity in the accessory olfactory bulb in response to social cues using fiberphotometry.

Engineered odorant receptors illuminate structural principles of odor discrimination

The paper uses engineered odorant receptors to uncover structural principles of odor discrimination by solving cryoEM structures of consensus ORs and comparing their ligand recognition properties.

Short-term consumption of ultra-processed semi-synthetic diets impairs the sense of smell and brain metabolism in mice

This study shows that short-term consumption of ultra-processed semi-synthetic diets impairs olfactory function and brain metabolism in mice.

Odor representations from the two nostrils are temporally segregated in human piriform cortex

The paper shows that odor information from each nostril is encoded separately in the piriform cortex, with ipsilateral odors processed faster than contralateral ones.

Lifelong olfactory deprivation-dependent cortical reorganization restricted to orbitofrontal cortex

The paper replicates and extends findings showing that lifelong olfactory deprivation leads to orbitofrontal cortex morphological changes, but not in piriform cortex.

The how, when, and what of odor valence communication between the olfactory bulb and piriform cortex

This study identifies the timing, frequency bands, and direction of odor valence communication between the olfactory bulb and piriform cortex using human neural activity and valence ratings.

Stimulus-induced theta band LFP oscillations format neuronal representations of social chemosignals in the mouse accessory olfactory bulb

Aberrant circuitry underlying olfaction in the face of severe olfactory bulb degeneration

This study shows that olfactory function can be preserved in mice with severe olfactory bulb degeneration due to altered circuitry compensating for lost structures.

Molecular diversity and connectivity of accessory olfactory system neurons

The paper investigates molecular diversity and connectivity patterns in accessory olfactory system neurons, revealing lineage- and sex-specific differences in connectivity.

Dynamic intraglomerular neuronal ensembles represent odor identity and concentration

The paper identifies intraglomerular neuronal ensembles in the olfactory bulb that encode both odor identity and concentration.

Odor modality is transmitted to cortical brain regions from the olfactory bulb

The paper demonstrates that the olfactory bulb encodes ortho and retronasal odor modality through mitral cell activity and shows that synaptic inhibition affects this encoding.

Regulatory Mechanisms Orchestrating Cellular Diversity in Cd36+ Olfactory Sensory Neurons Revealed by Single-Cell Multi-omics Analysis.

Sensory Adaptations: Insights into the Vomeronasal System of the Iberian Wolf

This study examines the vomeronasal system of the Iberian wolf, revealing functional similarities and microscopic differences compared to domestic dogs, and discusses implications for conservation strategies.

Reward contingency modulates olfactory bulb output via pathway-dependent peri-somatic inhibition

The paper shows reward-related inhibition in mitral cells of the olfactory bulb during odor discrimination, suggesting early value processing in sensory circuits.

Olfactory-driven beta band entrainment of limbic circuitry during neonatal development

This study shows that olfactory bulb activity synchronizes limbic circuits in the beta frequency range during neonatal development, shaping communication in the lateral entorhinal cortex, hippocampus, and prefrontal cortex.

The rules of sex and strain: deciphering the chemical language of inbred and wild mouse conspecific scents

The paper analyzes sex- and strain-specific chemical signals in mouse urine using VNO activity and molecular profiling to understand their discriminatory power and differences between inbred and wild mice.

Neural circuits for fast Poisson compressed sensing in the olfactory bulb

This paper proposes a rate-based Poisson compressed sensing model for the olfactory bulb that accurately detects odors within a single sniff.

Shedding light on human olfaction: electrophysiological recordings from sensory neurons in acute slices of olfactory epithelium

This study records electrophysiological properties of human olfactory sensory neurons using acute slices, revealing functional transduction mechanisms involving cAMP.

Olfactory cortex output pathways exhibit robust differences in their ability to drive learned aversion

The paper identifies differences in the ability of piriform cortex neurons projecting to different brain regions to drive learned aversion behavior.

Antagonistic interactions between odorants alter human odor perception.

The paper identifies odorant antagonists that reduce perception of malodors by interacting with olfactory receptors.