Insect Resistance and Genetics

Reduced processing and toxin binding associated with resistance to Vip3Aa in a resistant strain of fall armyworm (Spodoptera frugiperda) from Louisiana

Novel regional specific voltage-gated sodium channel (vgsc) mutations underlying pyrethroid resistance in Aedes albopictus (Skuse) from Northern Peninsular Malaysia

Preimaginal development of Aedes aegypti in brackish water produces adult mosquitoes with thicker cuticles and greater insecticide resistance

This study shows that Aedes aegypti mosquitoes developing in brackish water have thicker cuticles and higher insecticide resistance compared to those developing in fresh water.

Aedes aegypti aminopeptidase N3 is a functional binding receptor of Bacillus thuringiensis subsp. israelensis Cry4Ba toxin

This study identifies APN3 as a functional receptor for Cry4Ba toxin in Aedes aegypti, showing its role in toxin binding and larvicidal activity through genetic knockout experiments.

dsRNAEngineer: a web-based tool of comprehensive dsRNA design for pest control

dsRNAEngineer is a web tool for designing dsRNA molecules targeting pests while avoiding non-pest organisms, using transcriptome data to improve specificity and efficiency.

Cytochrome P450 inhibition impedes pyrethroid effects on insects through Nav channel regulation

This study shows that PBO inhibits cytochrome P450, reducing deltamethrin efficacy by altering Nav channel interactions through an octopamine-dependent pathway.

Genetic diversity in the IIS6 domain of Voltage Gated Sodium Channel (VGSC) gene among Aedes aegypti populations from different geographical regions in India

This study examines genetic diversity in the IIS6 domain of the VGSC gene in Aedes aegypti across India, identifying mutation frequencies and their correlation with insecticide resistance and population structure.

The dual resistance mechanism of CYP325G4 and CYP6AA9 in Culex pipiens pallens legs according to transcriptome and proteome analysis

This study identifies CYP325G4 and CYP6AA9 as key P450 enzymes involved in deltamethrin resistance in Culex pipiens legs through transcriptome and proteome analysis.

Temperature, but not plant cultivar, influence the efficacy of insecticidal dsRNA in Colorado potato beetle

This study shows that temperature affects the efficacy of insecticidal dsRNA in Colorado potato beetle larvae, while plant cultivar does not.

Field-evolved resistance to neonicotinoids in the mosquito, Anopheles gambiae, is associated with downregulation and mutations of nicotinic acetylcholine receptor subunits combined with cytochrome P450-mediated detoxification

Knockout of the SfVipR1 gene confers high-level resistance to Bacillus thuringiensis Vip3Aa toxin in Spodoptera frugiperda

This study shows that knocking out SfVipR1 in Spodoptera frugiperda confers high-level resistance to Vip3Aa toxin but not Cry1Fa.

Genome-wide Search for Gene Mutations likely Conferring Insecticide Resistance in the Common Bed Bug, Cimex lectularius

This study identifies gene mutations associated with pyrethroid resistance in bed bugs by comparing genomes of resistant and susceptible strains.

Simultaneous silencing of gut nucleases and a vital target gene by adult dsRNA feeding enhances RNAi efficiency and mortality in Ceratitis capitata adults.

This paper demonstrates that simultaneous silencing of intestinal nucleases and a vital gene via dsRNA feeding significantly improves RNAi efficiency and mortality in Mediterranean fruit fly adults.

Insecticide resistance in Myzus persicae collected from sweet pepper

This study investigates insecticide resistance in Myzus persicae by comparing sensitivity of specific genotypes to various insecticides and screening for resistance mutations.

CRISPR-mediated chromosome deletion facilitates genetic mapping of Vip3Aa resistance gene within complex genomic region in an invasive global pest

The paper identifies a Vip3Aa resistance gene in fall armyworm using CRISPR-mediated chromosome deletion and multi-omics analysis, revealing CHS2 as a candidate gene responsible for resistance.

The genetic architecture of resistance to flubendiamide insecticides in Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae)

This study identifies genetic loci associated with flubendiamide resistance in Helicoverpa armigera using GWAS and QTL mapping, revealing an oligogenic architecture and potential molecular markers for resistance monitoring.

Metabolomic differentiation of amino acid profiles in adult deltamethrin-resistant Aedes albopictus (L.)

This study identifies amino acids that differentiate deltamethrin-resistant from susceptible Aedes albopictus mosquitoes using GC-MS and logistic regression.

Effective target genes for RNA interference-based management of the cabbage stem flea beetle

This study identifies highly effective target genes for RNA interference-based control of the cabbage stem flea beetle, showing 100% mortality and reduced leaf damage with dsRNA.

Anatomy of a pest control failure: Introgression of cytochrome P450 337B3 alleles from invasive old-world bollworm into native corn earworm.

The paper identifies introgression of OWBW-specific CYP337B3 alleles into CEW in Colorado, linking it to pyrethroid resistance and agricultural impact.

Transcriptome analysis of Drosophila suzukii reveals molecular mechanisms conferring pyrethroid and spinosad resistance

This study identifies molecular mechanisms of pyrethroid and spinosad resistance in Drosophila suzukii through transcriptome analysis and validates findings using Drosophila melanogaster mutants.

CUAD biotechnology offers 0.5 USD per hectare for aphid control: innovative platform for low-cost plant protection

The paper demonstrates that CUAD-based oligonucleotide insecticides can effectively control aphids at a low cost, with minimal environmental impact.

Ruvbl1 is required for the reproduction of the corn planthopper, Peregrinus maidis

This study shows that silencing Ruvbl1 in corn planthoppers reduces egg production and hatching, suggesting it as a potential target for RNAi-based insect control.

CUADb-based oligonucleotide insecticides and RNA biocontrols: molecular bases and potential in plant protection

This paper reviews the molecular mechanisms and species-specific efficacy of CUADb-based oligonucleotide insecticides and RNAi-based RNA biocontrols for plant protection against insect pests.

PROTEOME DATA BASED IDENTIFICATION OF POTENTIAL RNAi TARGETS FOR COTTON MEALYBUG (Phenacoccus solenopsis Tinsley) POPULATION MANAGEMENT

The paper identifies potential RNAi targets for cotton mealybug management using proteome data and evaluates dsRNA delivery for pest control.

Uncovering the genetic diversity in Aedes aegypti insecticide resistance genes through global comparative genomics

The paper analyzes genetic diversity in four insecticide resistance genes of Aedes aegypti across global populations to identify mutations and copy number variations associated with insecticide resistance.

Optimising the production of dsRNA biocontrols in microbial systems using multiple transcriptional terminators.

This study optimizes dsRNA production in E. coli using synthetic transcriptional terminators, achieving higher yields and demonstrating scalability and efficacy in insect mortality.

Retrotransposon-mediated variation of a chitin synthase gene confers insect resistance to Bacillus thuringiensis Vip3Aa toxin

The paper identifies a retrotransposon-mediated mutation in the chitin synthase gene SfCHS2 as a cause of high resistance to Vip3Aa toxin in fall armyworm.

Superior target genes and pathways for RNAi mediated pest control revealed by genome wide analysis in the red flour beetle Tribolium castaneum

The paper identifies superior target genes and pathways for RNAi-based pest control in the red flour beetle using genome-wide analysis and validates effective targets for oral application in other pests.

Recombine and succeed: a story of Cry toxins to expand the host range

The paper identifies 50 recombination events in Cry toxins, showing domain swaps shape toxin sequences, bacterial strain composition, and host range through genomic context-driven recombination.

Transposon accumulation at xenobiotic gene family loci: a comparative genomic analysis in aphids

The paper examines TE accumulation at xenobiotic gene family loci across 20 aphid genomes, finding significant TE enrichment at these genes compared to others.