Topic · Surgery · Medicine

Infectious Diseases and Tuberculosis

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

3 papers

Contribution of cytotoxic CD8 T cells, neutrophils and type 1 interferon signaling to hyperinflammation in HIV-associated TB meningitis

James R. Barnacle, Nonzwakazi Bangani, Hubert Slawinski, Christopher Barrington, Katalin Andrea Wilkinson, Cari J. Stek, Rachel Lai, Fabrice Bonnet, Graeme Meintjes, Brian D. Robertson, Martin Gengenbacher, Angharad Davis, Daniel L. Barber, Anne O’Garra, Robert John Wilkinson

This study identifies a hyper-inflammatory immune response in HIV-associated TB meningitis, marked by cytotoxic CD8 T cells, activated neutrophils, and type 1 interferon signaling.

bioRxiv · Mar 23, 2026 · PreprintImmunology

Digital PCR detection of Mycobacterium tuberculosis and HIV-1 co-localization in spinal tuberculosis biopsies

Robyn Waters, Adrian R. Martineau, Maritz Laubscher, Robert Neil Dunn, Michael F. G. Held, Melissa-Rose Abrahams, Anna K. Coussens

The paper uses ddPCR to detect and quantify Mtb and HIV-1 in spinal tuberculosis biopsies, finding reciprocal relationships between pathogen abundance and immune microenvironment factors.

bioRxiv · Jun 11, 2025 · PreprintMicrobiology

A Bayesian analysis of the association between Leukotriene A4 Hydrolase genotype and survival probability of tuberculous meningitis patients treated with adjunctive dexamethasone

Laura J. Whitworth, Jacob Coxon, Arjan van Laarhoven, Nguyễn Thụy Thương Thương, Sofiati Dian, Bachti Alisjahbana, Ahmad Rizal Ganiem, Reinout van Crevel, Guy Edward Thwaites, Mark A. Troll, Paul H. Edelstein, Roger Sewell, Lalita Ramakrishnan

The paper uses Bayesian analysis to show the LTA4H TT genotype improves survival in TBM patients in Vietnam and Indonesia, but only when disease severity is not the primary cause of mortality.

bioRxiv · Aug 3, 2020 · PreprintMolecular Biology