Corneal Surgery and Treatments

Perturbation of epithelial and limbal stem cell identity in a mouse model of pathologic corneal neovascularization

This study examines the effects of corneal injury and duloxetine treatment on limbal stem cell identity using single-cell transcriptomics in a mouse model.

Integrated tear proteomics define the molecular blueprint of corneal epithelial repair

This study identifies conserved and species-specific molecular pathways in tear film during corneal wound healing in humans and mice.

V-Cornea:A computational model of corneal epithelium homeostasis, injury, and recovery

V-Cornea models corneal epithelium homeostasis, injury, and recovery, accurately predicting healing times and structural changes following trauma or chemical exposure.

A Practical and Safe Model of Nitrogen Mustard Injury in Cornea

This paper introduces a safe and practical model using mechlorethamine gel to study sulfur mustard-induced corneal injuries in ex vivo porcine corneas.

In Situ UNIversal Orthogonal Network (UNION) Bioink Deposition for Direct Delivery of Corneal Stromal Stem Cells to Corneal Wounds

This paper develops a collagen bioink for delivering corneal stem cells to wounds, promoting transparency and re-epithelialization in a rabbit model.

Inhibition of pterygium cell fibrosis by the Rho kinase inhibitor

This study investigates the effect of a Rho kinase inhibitor on pterygium cell fibrosis, finding it reduces cell viability, migration, and extracellular matrix markers.

The Hippo/YAP Pathway Mediates the De-differentiation of Corneal Epithelial Cells into Functional Limbal Epithelial Stem Cells In Vivo

This study shows corneal epithelial cells can de-differentiate into functional limbal epithelial stem cells in vivo, mediated by the Hippo/YAP pathway, offering a new approach for treating limbal stem cell deficiency.

Single cell RNA-seq identifies developing corneal cell fates in the human cornea organoid

This study uses single-cell RNA-seq to map cell fates in human cornea organoids and identifies developmental states of corneal cell types.

Multiple roles of Pax6 in corneal limbal epithelial cells and maturing epithelial cell adhesion

This study investigates the role of Pax6 in corneal limbal epithelial cells and maturing epithelial cell adhesion through conditional depletion in different ocular domains.

Time-course single-cell RNA sequencing reveals transcriptional dynamics and heterogeneity of limbal stem cells derived from human pluripotent stem cells

This study uses time-course single-cell RNA-seq to analyze transcriptional dynamics and heterogeneity of hPSC-derived limbal stem cells, identifying new markers and developmental trajectories.

Defining compartmentalized stem and progenitor populations with distinct cell division frequency in the ocular surface epithelium

The paper identifies compartmentalized stem and progenitor populations in the ocular surface epithelium with distinct division frequencies using lineage tracing in mice.