Phosphodiesterase function and regulation

Pivotal role of PDE10A in the integration of dopamine signals in mice striatal D1 and D2 medium-sized spiny neurones.

The paper investigates the role of PDE10A in dopamine signal integration in striatal D1 and D2 MSNs using FRET biosensors, finding that PDE10A uniquely reduces cAMP to baseline in both neuron types.

Radiosynthesis and preclinical evaluation of a carbon-11 labeled PDE7 inhibitor for PET neuroimaging

This paper develops and evaluates [11C]26, a PET probe for imaging PDE7 in the brain, showing promising in vitro performance and moderate specific binding in nonhuman primates.

cGMP signaling: probing antagonistic cyclic nucleotide platelet signals by modeling and experiment

The paper develops and validates a model of cGMP signaling and VASP phosphorylation in platelets using data-driven approaches and experimental validation.

Inhibition of phosphodiesterase - 10A by Papaverine protects human cortical neurons from quinolinic acid-induced oxidative stress and synaptic proteins alterations

This study shows that papaverine inhibits PDE10A, reducing oxidative stress and protecting synaptic proteins in human cortical neurons exposed to quinolinic acid.

Investigating the role of N-terminal domain in phosphodiesterase 4B-inhibition by molecular dynamics simulation

This study uses molecular dynamics simulations to analyze the role of the N-terminal domain in PDE4B inhibitor binding and shows it enhances ligand affinity and stability.

Guanine-nucleotide Exchange Modulator, GIV/Girdin, Serves as a Tunable Valve for Growth Factor-Stimulated Cyclic AMP Signals

The paper presents a network-based model of GIV/Girdin-dependent cAMP signaling, revealing its role as a tunable control valve distinct from GPCRs and PDEs.