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This paper develops a computational platform to evaluate anti-sickling agents by integrating PK/PD models with RBC sickling kinetics, demonstrating its utility in predicting therapeutic efficacy and noncompliance outcomes for existing and potential drugs.

This study uses single-cell transcriptomics to analyze NK cell expansion in PBMC cultures, identifying factors influencing donor variability and suggesting strategies to improve NK cell fraction and expansion.

This study evaluates how different temporal resolutions affect CFD-derived left atrial flow metrics, finding that higher frame rates improve accuracy while lower rates preserve patient ranking.

The paper introduces an adaptive feature-weighted stacking ensemble model for predicting prolonged length of stay in elderly trauma patients, showing improved predictive accuracy over standard methods.

This study uses biophysical methods to characterize lipid nanoparticle properties and predict their transfection efficiency.

This study uses microspectroscopic techniques to analyze sulfur species and zinc distribution in rat temporomandibular joint condylar zones, linking them to biological pathways and potential diagnostic biomarkers.

This paper develops antigen-dextramers to stain and functionally assess CAR T cells, showing they enable both detection and activation analysis with adjustable antigen density.

This study uses human muscle microtissues to show that humoral factors from ICU patients predict clinical risk factors of ICUAW and CIM.

This paper develops an in vitro cardiac fibrosis model using exogenous ECM to study how extracellular environment affects tissue formation and cell behavior.

This study uses base editing to create a universal FIX variant for hemophilia B treatment, increasing FIX activity in cell and mouse models.

This study shows that nuclear mechanics influence intestinal stem cell differentiation by sensing tissue shape and modulating lamin-A levels.

This paper introduces a scalable filtration method to isolate exomeres, showing they are stable, miRNA-rich NVEPs that could improve RNA delivery.

The paper characterizes CDK4/hTERT-immortalized ovine satellite cells through multi-omics analysis, showing molecular changes and preserved myogenic traits relevant for cultivated meat.

The paper investigates how ultrasound affects microparticle behavior in disturbed vascular vortices, showing microbubbles self-assemble and anchor to vessel walls, suggesting a new therapeutic strategy.

This paper engineers isoprene production in Chlamydomonas reinhardtii using herbicide resistance markers and CO2-fed cultivation optimization to generate biomass and isoprene from wastewater.

This paper introduces a confounder-aware foundation model for cell imaging that improves phenotype profiling and compound target prediction, achieving state-of-the-art results for both seen and unseen compounds.

This study shows that H2 solubility limits C. ljungdahlii growth on CO2 and H2, but high H2 mass transfer enables rapid growth using CO2 as the sole carbon source.

This paper develops a machine vision-enhanced lateral flow immunoassay using functionalized gold nanoparticles for rapid, sensitive detection of cardiac biomarkers cTnI and Myo in point-of-care settings.

This paper introduces a near-IR dual-RNA/DNA-targeting probe that enables discrimination of multiple cell states by detecting RNA-DNA changes, offering greater informational content than existing fluorophores.