Discover, rate, and discuss biology preprints.

This paper develops a synthetic receptor system that enables mesenchymal stromal cells to target and respond specifically to damaged cartilage in osteoarthritis.

This study shows that deleting the MpkA kinase in Aspergillus nidulans alters mycelial material mechanical properties, including increased tensile strength and resistance to fragmentation.

This study examines metabolic changes in chondrocytes under simulated microgravity, finding metabolic shifts linked to early osteoarthritis.

This paper shows that sparse neural networks reduce power consumption in implantable BMIs by pruning decoders, enabling efficient decoding with minimal performance loss.

The paper introduces a label-free microfluidic platform to sort cells based on glycolytic activity by measuring pH changes, enabling the isolation of distinct metabolic cell populations.

This study evaluates the robustness of time domain near infrared spectroscopy to variations in skin pigmentation using tissue phantoms and pediatric volunteers, finding negligible effects on results.

This paper develops a system for continuous monitoring of spinach spoilage using paper-based electrical gas sensors integrated into packaging, enabling smartphone-based evaluation via NFC.

This paper demonstrates that graphene-polymer nanofibers can be optically stimulated to enhance electrical activity in stem cell-derived cardiomyocytes and brain organoids.

This study develops two mouse models with acquired skin appendage dysfunction to study regeneration, showing that thin grafts produce skin with minimal appendages.

This paper uses laser speckle imaging to monitor chick embryo heart rate and blood flow in response to nifedipine and amlodipine, showing drug-specific effects on cardiovascular parameters.

This study evaluates the cytoprotective and neuroinductive effects of three thiol-containing simple signaling molecules on neural stem cells exposed to oxidative stress.

This paper develops an optical nanosensor using carbon nanotubes to rapidly detect estrogen receptor status in breast cancer biopsies with high accuracy.

This paper introduces TRACeR-II, a platform for developing MHC-II binders using a single loop, demonstrating its versatility and applicability to SARS-CoV-2 peptides.

This paper develops an in silico affinity maturation pipeline to enhance nanobody binding to the SARS-CoV-2 Omicron RBD, achieving three-fold improved affinity through computational and experimental validation.

This study shows PIEZO1 regulates collagen synthesis in hASCs based on substrate architecture, with YAP/TAZ translocation and collagen production being independent outcomes of PIEZO1 activation.

This paper introduces a variational method for removing stripe artifacts from images, showing effectiveness in light-sheet microscopy, FIB-SEM, and remote sensing data.

The paper develops a computational model to predict bilirubin removal in binder dialysis systems and finds it is independent of dialysate flow rate within clinical ranges.

The paper simulates alpha particle doses at the micron scale from prostate cancer bone metastatic biopsies using GATE to evaluate energy and dose distributions in patient-derived specimens.

The paper decomposes reactive joint torques during balance recovery into feedforward and feedback components using a modified sensorimotor response model.

This paper develops a human heart assembloid model that recapitulates cardiac neural crest integration and reveals antidepressant effects on cardiac development.