Discover, rate, and verify biology preprints.

Fibronectin-Assisted Coating of Low-Molecular-Weight Fucoidan Creates a Biomimetic Interface for Endothelialization of Cobalt-Chromium Stents

This paper develops a fibronectin-LMWF coating for Co-Cr stents that enhances endothelialization by improving cell adhesion, proliferation, and cytoskeletal organization without cytotoxicity.

A compact three-way junction oligonucleotide probe for widefield and super-resolution imaging of RNAs and proteins

This paper introduces a compact three-way junction oligonucleotide probe for multiscale RNA and protein imaging, enhancing detection while preserving nanoscale resolution and enabling large-field tissue analysis.

Wearable Estimation of Knee Joint Contact Forces: SiMPLeSENSE, a Simulated-IMU Pipeline Validated Against In Vivo Loads

The paper develops SiMPLeSENSE, a simulated-IMU pipeline that estimates knee joint contact forces using motion capture and EMG, validated against in vivo measurements with high accuracy.

Engineering and characterisation of AAVS1 FRT cell lines for inducible and dose-dependent gene expression

This paper develops a stable RPE1 cell line with inducible and dose-dependent transgene expression using CRISPR/Cas9 and FRT/Tet-On systems, validated through multi-omics analysis.

Patient-Derived Synovium-on-a-Chip Recapitulates Disease and Treatment Response and Permits Study of Resistance

This paper develops a patient-derived synovium-on-a-chip model to study RA disease and treatment response, finding that it correlates with clinical outcomes and identifies ECM signaling as a resistance mechanism.

MaxCAT-Net: Hybrid Transformer-Based Skin Lesion Classification and Lightweight Segmentation with Calibration and Cross-Dataset Validation

MaxCAT-Net improves skin lesion classification and segmentation with hybrid architecture and calibration, showing performance on benchmark datasets but with preliminary results.

Cross-species structure-mechanics prediction in the intervertebral disc

This study develops a cross-species framework linking collagen structure to mechanical vulnerability in intervertebral discs using multiscale imaging and modeling.

Bioresorbable, Injectable In Situ-Formed Electroactive mRNA-Delivering Device for Precision Gene Therapy after Myocardial Infarction

This paper develops an injectable, bioresorbable device for localized mRNA delivery to the heart after myocardial infarction, showing improved cardiac function and reduced remodeling in mice.

Feasibility of an anterior abdominal electrode array for non-invasive measurement of uterine contractions across the menstrual cycle

This study evaluates the feasibility of using a non-invasive anterior abdominal electrode array for measuring uterine contractions across the menstrual cycle through simulation and experiment.

Bone Response to Mechanical Loading is Highly Heritable and Correlates with Osteocyte Lacunar Morphology in Genetically Diverse Mouse Strains

This study shows that genetic background strongly influences bone response to mechanical loading in mice, with high heritability and correlations with osteocyte lacunar morphology.

An adjuvant for in vivo CAR-T therapy potentiation against solid tumors

This paper introduces an adjuvant (iCTA) that enhances in vivo CAR-T therapy against solid tumors by improving T-cell recruitment, antigen presentation, and tumor microenvironment.

Fluidized Bed Cathodes Enable High-Rate CO2 to Formate Production and In Situ Microbial Growth

This paper develops a fluidized bed cathode system for CO2 to formate electrochemical conversion that supports in situ microbial growth for biomass production.

Cell-in-drop genotyping detects megabase-scale loss of heterozygosity as a quantitative marker for CRISPR-Cas9 on-target toxicity

Investigating the therapeutic potential of soluble TREM2 interactions with Transgelin-2 in Alzheimer's disease

This study identifies the structural basis of sTREM2-TG2 interaction in Alzheimer's disease and develops improved peptide modulators based on these findings.

Raman-probe-derived biomarkers account for cartilage composition, structure, and viscoelastic properties

This study uses Raman spectroscopy to identify biomarkers that correlate with cartilage composition, structure, and viscoelastic properties in equine osteochondral explants.

De novo design of mini-proteins as specific binders to PACAP-38, a key mediator of migraine

This study designs mini-proteins that bind PACAP-38 with high affinity, showing improved potency and stability compared to earlier versions.

An Improved Manufacturing Method for Infusible Extracellular Matrix Materials to Enable Efficient Scale-Up, Improved Efficacy, and Clinical Translation

This paper introduces a new manufacturing method for infusible extracellular matrix (iECM) using depth filtration and tangential flow filtration (DF-TFF) to improve production efficiency, concentration, and compliance with cGMP standards.