Discover, rate, and verify biology preprints.

Closed-loop optical optimization enables patterned retinal stimulation in vivo at cellular scales

This paper introduces a closed-loop optical platform for precise retinal stimulation in mice, achieving high-resolution patterned stimulation with real-time focus correction.

Prior photon measurement density function constructed in a standard channel space for functional near-infrared spectroscopy

The paper constructs a prior photon measurement density function (PMDF) using a standard channel space and structural MRI database, outperforming template-based PMDF in fNIRS studies.

Hyaluronidase isoforms can promote or suppress glioma invasion within 3D Hyaluronic Acid Matrices

This study shows HYAL1 suppression in glioma cells increases invasion by altering ROS levels and adhesion molecule expression in 3D hyaluronic acid matrices.

Spatial control of light-responsive proteins and optogenetics within hydrogels via volumetric bioprinting

This study uses volumetric bioprinting to enable post-printing optogenetic stimulation of cells within hydrogel constructs, demonstrating spatial control over light-responsive proteins and gene expression.

Nature-inspired nanodiscs for lesion-targeted delivery reprogram macrophages and attenuate established abdominal aortic aneurysms

This paper develops nanodiscs for targeted delivery of an anti-inflammatory drug to macrophages in AAA, showing reduced disease progression in mice.

Patterned ELR-Gelatin Hydrogels Enable Rapid Endothelial Monolayer Formation via Bioactive Matrix Chemistry and Surface Topography

Immunomodulatory mechanisms of submicron phosphatidylserine-exposing polymeric particles (PSPs)

This study develops submicron phosphatidylserine-exposing polymeric particles (PSPs) that modulate macrophage activity by reducing inflammation and promoting resolution through redox adaptation and suppression of inflammatory signaling.

Colorimetric Hydrogel Dressing with Smartphone Detector for Point-of-Care Wound pH Monitoring

This paper develops a colorimetric hydrogel dressing that uses a smartphone camera to monitor wound pH in real-time, enabling point-of-care diagnostics for chronic wounds.

Closed-Loop Vibrotactile Neuromodulation for Reducing Tremor-Related Propranolol Use

This paper develops a closed-loop vibrotactile stimulation system to reduce tremor amplitude and propranolol use by modeling a nonmonotonic tremor-vibration relationship.

Dissolution of Phosphate and Precipitation of Carbonate in the Bio-mineralization of the Bivalve Shell Limnoperna fortunei

This study investigates the role of phosphate and carbonate in the biomineralization of bivalve shells, identifying phosphate as the primary phase and carbonate as a secondary phase in Limnoperna fortunei.

Spectroscopic DNA-PAINT for simultaneous multiplexed super-resolution microscopy

This paper introduces sDNA-PAINT, a method that improves spectral precision and multiplexing in super-resolution microscopy using DNA Origami Nanorulers and spectroscopic SMLM.

The crossmodal congruency task as a measure of intuitiveness of sensory feedback in the lower limb

The study tests if a crossmodal congruency task can measure the intuitiveness of sensory feedback in lower limb prostheses, finding it effective at the knee but not the foot.

Sustained Volumetric Compression Induces Cell Jamming and Primes Breast Cancer Cells for Enhanced Post-Compression Migration and Invasion

This study shows that sustained volumetric compression of breast cancer cells induces a jammed state, which primes them for enhanced migration and invasion after recovery.

Predictive vascular growth and remodeling in pulmonary hypertension: simulating intervention effects from captured evolution

This paper develops a multiscale computational model of pulmonary vascular remodeling in PH, showing it can predict pressure, wall thickness, and stiffness changes in response to treatment.

Scalable 3D Bioprinting of Human Islets in a Pancreatic Decellularized Extracellular Matrix-Enriched Bioink for Beta-Cell Replacement Therapy

This paper develops a 3D bioprinting method using decellularized extracellular matrix-enriched bioinks to create functional human islet constructs for beta-cell replacement therapy in type 1 diabetes.

Evidence of tornadic phenomena in cerebral aneurysms

This paper introduces a topology-based framework to describe near-wall hemodynamics in cerebral aneurysms, identifying tornadic-like fluid structures linked to aneurysm pathology and validated using 4D flow MRI.

Blood-Mediated Opto-Acoustic Stimulation of Brain Cortex at Sub-millimeter Precision

This paper introduces blood-mediated optoacoustic stimulation (BOAS) for precise brain cortex stimulation, showing it can trigger neuronal activity comparable to natural visual stimulation and is more efficient than photothermal methods.

Design and characterization of SAKe, a new building block for protein self-assembly

The paper introduces SAKe, a designer protein that forms stable, pH-dependent two-dimensional assemblies for functional protein-based materials.

FLIP2: Expanding Protein Fitness Landscape Benchmarks for Real-World Machine Learning Applications

FLIP2 adds seven protein fitness datasets and 16 splits for enzymes, light-sensitive proteins, and interactions; simple ridge and zero-shot baselines often rival fine-tuned protein language models.

Cyclic voltammetry electropolymerization of PEDOT: Polydopamine on gold electrodes

This paper describes a method to create PEDOT:PDA coatings on gold electrodes using cyclic voltammetry, resulting in enhanced electrochemical performance for bioelectronic applications.