Discover, rate, and verify biology preprints.

Constitutive discovery in the living human heart

This paper develops a framework to discover constitutive models of passive myocardial mechanics directly from in vivo cardiac imaging data, improving accuracy over existing models.

A mechanistic framework for photon-to-carbon efficiency: coupling photosynthetic energy supply and light respiration in microalgae

The paper develops a mechanistic framework to link photon absorption, energetic coupling, and light respiration in microalgae to improve photon-to-carbon efficiency.

Capillary Network Generation Framework for Estimating Volumetric Capillary Density from Histological Vascular Measurements

This paper develops a framework to estimate volumetric capillary density from histological vascular measurements by generating 3D capillary networks that match experimental data.

Tissue nanotransfection-mediated induction of neurogenic programs promotes myoprotective responses in denervated skeletal muscle

This study uses tissue nanotransfection to deliver neurogenic factors to denervated muscle, promoting myoprotective responses and regeneration.

Aligned basement membrane-modified collagen scaffolds for skeletal muscle tissue engineering

This study develops collagen-glycosaminoglycan scaffolds with aligned pores and basement membrane proteins to enhance skeletal muscle tissue engineering.

Structure-guided design of a CD81-binding mini-protein that blocks hepatitis C virus entry

This paper designs a CD81-binding mini-protein using deep learning to block HCV entry, showing high affinity, stability, and antiviral activity.

Peptide additives reprogram the lipid nanoparticle corona and enhance gene delivery in a serum-free environment for lung epithelium

This study develops peptide-lipid nanoparticles (hpLNPs) for pulmonary DNA delivery, showing enhanced transgene expression and demonstrating the importance of serum interactions for in vivo efficacy.

Overcoming the Limits of Traditional Rate Calculations from Sparse Concentration Data: A Probabilistic Framework for Bioprocess Modeling

This paper introduces a probabilistic framework using Bayesian inference to improve metabolic rate estimation from sparse concentration data in bioprocesses.

A Method for Image-Based Modeling of Uterine Passive Mechanics During Late Pregnancy

The paper develops an image-based modeling pipeline to study uterine passive mechanics during late pregnancy, achieving computational savings and accurate strain predictions.

Tuning selectivity of electrochemical sensors with polymer coatings

This study shows that polymer coatings can tune the oxidation potentials of biomarkers, improving selectivity in electrochemical sensors for molecular discrimination.

Biodegradable Intra-arterial Devices for Focal Drug Delivery to Targeted Organs

This paper develops biodegradable intra-arterial drug delivery devices for targeted organ treatment, showing improved drug levels in the kidney and brain compared to oral administration.

Interstitium-mimicking porous alveolar membranes enable physiologic aerosol transport and distinct acute-chronic lung injury responses

This paper develops an interstitium-mimicking alveolar membrane for lung-on-chip systems that enables physiologic aerosol transport and reveals distinct acute-chronic lung injury responses.

Expanding genetic code to generate human brain organoids with both vasculature and microglia

This paper develops a method to generate human brain organoids with vasculature and microglia using genetic code expansion, showing enhanced neurovascular interactions and ZIKV-induced dysfunction.

LYNX: a deep generative model for linking spatial dynamics and cellinteractions in multimodal spatial data

LYNX is a deep generative model that integrates multimodal spatial data to model spatial dynamics and cell-cell interactions across tissues.

Field-Correcting GRAPPA (FCG): a technique to correctspatiotemporal-varying phase errors in Echo Planar Imaging

This paper introduces FCG, a technique that corrects spatiotemporal-varying phase errors in EPI using an MLP, improving image quality on high-performance systems.

Murine Abdominal Aortic Aneurysm Intraluminal Thrombus Composition and Structure

This study investigates the composition and structure of intraluminal thrombus in murine abdominal aortic aneurysms and its association with aneurysm expansion.

Xeno-Free Peptide-Functionalized Hydrogels Support hiPSC Encapsulation and In Situ Differentiation into Cardiomyocytes with Enhanced Structural Maturation

This study develops a xeno-free hydrogel platform to support hiPSC expansion and in situ differentiation into structurally mature cardiomyocytes.

CFD-Informed Hybrid Modeling Unlocks Scalable, Tunable Amino Acid Production in Methanothermobacter marburgensis

This study develops a hybrid modeling approach to scale up amino acid production in Methanothermobacter marburgensis using CFD and DOE techniques.

Cumulative Transfer Function for Assessment of MRI-Induced RF Heating Risk in Pediatric Patients Implanted with Bifurcated Leads

This paper develops and validates a cumulative transfer function (cTF) framework to improve RF-heating risk assessment for bifurcated cardiac leads in MRI, showing significant error reduction compared to single-branch approximations.

Lower-limb mechanical power accounts for running energy expenditure and enables single-IMU estimation

This study quantifies how segment-level mechanical power contributes to running energy expenditure and shows that hip joint power from a single IMU can accurately estimate EE.