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Coherent Structured Illumination Microscopy with Enhanced Optical Sectioning

This paper introduces a 5-beam c-SIM technique that improves optical sectioning and lateral resolution in non-fluorescent samples by suppressing coherent defocus effects.

Growth factor-free synthetic matrices reveal intrinsic skeletal progenitor competence

This study shows that growth factor-free synthetic matrices reveal donor-specific differences in human skeletal progenitor cell osteogenic potential, which are masked by conventional methods.

Simple 3D-Printed Stirred Bioreactor Enhances Retinal Organoid Production Via Improved Oxygenation

The paper develops a 3D-printed stirred bioreactor to improve retinal organoid production by maintaining physiological oxygen levels, enhancing yield and consistency.

Evaluating the effects of aging on biodistribution and gene silencing activity of lipid-siRNA conjugates delivered into cerebrospinal fluid

This study evaluates how aging affects the distribution and gene silencing activity of lipid-siRNA conjugates in the cerebrospinal fluid of mice.

Analysis of Plasma Extracellular Vesicles in Normal-Weight and Overweight Type 2 Diabetes Using Multimodal SERS and RNA-Seq

The paper uses multimodal SERS and RNA-Seq to analyze plasma extracellular vesicles in T2DM patients, identifying subtype-specific molecular features and miRNA expression patterns.

Direct quantification of the metabolic heat output of individual Drosophila brains

This study measures metabolic heat output of individual Drosophila brains to examine effects of sex, genotype, age, and disease on brain metabolism.

Effects of Ankle Stiffness on Total Leg Kinematics, Mechanics, and Muscle Activation during Walking

This study examines how changes in ankle stiffness affect gait mechanics, muscle activation, and joint work during walking in healthy individuals.

Minimally invasive delivery of optical nanosensors using injectable hydrogels

This paper introduces injectable hydrogels encapsulating SWCNT sensors for in situ drug concentration monitoring, showing preserved fluorescence response in physiological conditions.

Entanglement-governed protein networks enable mechanically adaptive artificial skin for transplantation-scale skin replacement

This paper develops a mechanically adaptive artificial skin using entanglement-mediated protein networks, showing improved toughness, regenerative compatibility, and wound healing in mice.

Bi-level inverse optimal control for preoperative prediction of postoperative squat kinematics after total knee replacement

This paper develops a predictive simulation framework using bi-level inverse optimal control to link preoperative implant alignment to postoperative squat kinematics after total knee replacement.

In vivo brain temperature measurement using quantum dot imaging temperature sensors

This study uses quantum dot imaging temperature sensors to measure brain temperature in mice, revealing vascular cooling's role in protecting against heat stress in pathological conditions.

Validation of Dynamic Bayesian Optimization for Human-in-the-Loop Optimization of Exoskeleton Control at User-Driven Walking Speed

This study validates dynamic Bayesian optimization (DBO) for human-in-the-loop exoskeleton control, showing it improves walking speed and personalization compared to standard Bayesian optimization (BO).

Attenuation of Inflammatory Cytokines by Selective Vagal Motor Stimulation via Silicone Spiral Nerve Cuff

This study shows that optogenetic stimulation of cholinergic vagal neurons reduces pro-inflammatory cytokines, while glutamatergic stimulation does not, demonstrating the importance of pathway selectivity in vagus nerve stimulation.

Continuous Capture of recombinant AAV Particles Using Twin-Column CaptureSMB

This paper introduces a continuous twin-column capture process (CaptureSMB) for purifying rAAV5 directly from perfusion harvest, improving yield and efficiency while maintaining product quality.

Microfluidic Core-Shell Encapsulation Enables Scalable Generation of Apical-Out Intestinal Spheroids

This paper introduces a microfluidic method to generate scalable apical-out intestinal spheroids by encapsulating cells in core-shell hydrogel microcapsules.

Systematic Evaluation of Signal Peptide-Driven Protein Secretion in the Fast-Growing Cyanobacterium Synechococcus sp. PCC 11901

This study evaluates signal peptide-driven protein secretion in Synechococcus sp. PCC 11901, finding that FutA from the Tat pathway outperforms Sec pathways, but optimal selection depends on the target protein.

Structural co-modulation: An individualized measure of inter-component interactions in source-based morphometry

This paper introduces a structural co-modulation measure to quantify individualized interactions between brain components using source-based morphometry, finding reduced co-modulation in schizophrenia patients.

AI-enabled discovery of small molecules targeting complementary pathways for hair follicle rejuvenation

This study uses AI to discover small molecules that rejuvenate hair follicles by targeting complementary pathways, showing increased cell viability and suppression of follicular miniaturization.

Emulating the gingival-tooth interface during bacterial, fungal, and viral infection in a microphysiological model of the human oral cavity

This study develops a microphysiological model of the human oral cavity to study host-microbe interactions during bacterial, fungal, and viral infections.

3D-Printed Scaffolds for Local Chemotherapeutic Delivery in Resected Spine Metastases

This study evaluates 3D-printed composite scaffolds for local chemotherapy delivery in spinal metastases, showing effective drug release and bone integration in animal models.