Discover, rate, and discuss biology preprints.

The paper develops an analytical framework for reaction diffusion equations in Ca nanodomains, showing that Ca bound buffers and sensors propagate as traveling waves, supported by experimental measurements.

This study shows Bacillus subtilis biofilms use polymer composition to drive gel formation and morphological transitions through swelling and cross-linking.

The paper investigates how the highly acidic SH3 domain binds to an intrinsically disordered partner through an encounter complex intermediate, revealing the role of long-range electrostatic interactions.

This paper investigates how whirligig beetles generate hydrodynamic torque for rapid surface-to-underwater diving by bending their abdomen.

This paper derives a metabolic cost-based model for optimal vascular tree shear stress profiles and shows how staged growth and fluctuating demand influence vascular topology.

The paper introduces Zephyr, a diffusion model for generating structural ensembles of disordered proteins, achieving high accuracy and faster sampling than molecular dynamics simulations.

The paper tests a dynamical model of PU.1 regulation during hematopoietic differentiation and finds that additional regulatory inputs beyond autoregulation and C/EBP feedback are required to explain observed data.

This study uses molecular dynamics simulations to investigate conformational changes in the ND2 subunit of complex I, revealing a previously unobserved structural transition linked to proton pumping.

This paper introduces a method using ultrasonic excitation in plunge freezing tweezers to reduce preferred particle orientation in cryo-EM, achieving a complete reconstruction of hemagglutinin at 2.5 Å resolution.

This study identifies a 'kiss-and-ride' mechanism for lipid transfer mediated by Osh6, showing that transient membrane tethering facilitates cargo extraction and transport.

This study investigates the functional roles of red chlorophylls in the PSI core antenna by mutating specific sites and analyzing structural and spectroscopic changes.

This study shows that Gag proteolysis drives HIV-1 Env conformational closure through the gp41 cytoplasmic tail, revealing a mechanism for immune evasion.

This study maps 5mC and H3K9me3 co-localization on individual chromosomes using AFM, revealing mechanical stiffness differences between cancer and non-tumorigenic cells.

The paper studies how mechanical forces, bacterial growth, and viral infection dynamics interact during the expansion of an E. coli colony, revealing phage hitchhiking and anisotropic spread.

This study identifies CTL1 as a phospholipid-binding protein that deforms membranes, revealing its structural basis and potential role in phospholipid homeostasis.

This study uses smFRET to reveal conformational changes in the prokaryotic NavAb channel during slow inactivation, identifying key residues that coordinate structural transitions.

This study introduces OpenCGChromatin, a model that simulates chromatin structure and phase separation, revealing how linker-DNA length and histone modifications affect chromatin organization.

The paper identifies an anisotropic attractor and predictive feedback control mechanism governing cellular density homeostasis using single-cell mass-volume measurements.

This paper introduces fp-SMD to simulate single-molecule force spectroscopy data by aligning simulation timescales with experiments, revealing force-induced pathway switching in a host-guest complex.

The paper derives a non-equilibrium model for biomolecular condensate sorting, identifying a critical Damkohler number threshold for bistability and quality control.