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The paper introduces a surface-free single-molecule blotting platform called DNA Hanger that reduces nonspecific binding and improves sensitivity for detecting sub-picomolar concentrations of fluorophore-conjugated proteins.

This study analyzes how different antibodies interact with SARS-CoV-2 spike protein using computational methods to identify binding hotspots and resistance mechanisms against variants.

The paper investigates low-frequency sound percepts (LFSPs) by comparing hearing thresholds and spontaneous otoacoustic emissions in individuals with and without LFSPs, suggesting subjective tinnitus as a likely cause.

This study creates and characterizes extracellular biomolecular condensates using heparan sulfate to explore their interactions with cells and properties.

The paper investigates how glandular trichome rupture in tomato plants serves as a rapid and sensitive defense mechanism against insect herbivory.

This study identifies the mumps virus SH protein as a pentameric viroporin and shows it functions as a chloride channel inhibited by BIT225.

This study shows that Ydj1, a heat shock protein 40, prevents amyloid fibril formation by promoting heterotypic phase separation of tau through electrostatic and hydrophobic interactions.

This study uses cryo-EM and HDX-MS to reveal structural changes in TRPM8 channels that underlie cold sensitivity and menthol activation.

This paper introduces a dominance analysis framework to determine the molecular mechanism of condensate modulation, demonstrating its application to G3BP1/RNA condensates disrupted by suramin.

This study shows that base distribution along an invading strand strongly affects DNA-RNA strand displacement kinetics, enabling design of sequences with reaction rates spanning two orders of magnitude.

This study reveals that membrane phosphoinositides allosterically regulate β-arrestin dynamics, enabling engagement with minimally phosphorylated GPCRs.

This study uses RNA-seq to analyze gene expression changes in human blood after X-ray exposure, identifying novel radiosensitive genes and pathways.

ProGuide generates structural models of protein conformations using DEER-derived distance restraints, revealing novel conformational states in the angiotensin II type 1 receptor.

This paper uses molecular dynamics simulations to study the asymmetric opening of MscL mutants under tension, revealing the S1 state and its free energy profile.

This study determines the structure of the PelBC exopolysaccharide transporter in Pseudomonas aeruginosa and identifies its gating mechanism for exopolysaccharide transport.

This paper analyzes sequence-dynamics relationships in subtilisin-like serine proteases to understand thermal adaptation mechanisms, revealing structural features that contribute to thermophilic and psychrophilic stability.

This paper introduces DEFORM-Net, a deep learning method for estimating full-field displacement in biological images, outperforming traditional and recent approaches in accuracy, speed, and spatial sampling.

The paper measures interfacial tension in epithelial tissues and shows how it contributes to delamination from substrates, revealing mechanical stability mechanisms.

The paper investigates how optimizing information transmission between FGF and ERK signaling in ascidian embryos depends on cell surface contact geometry, finding that optimal contacts align with experimental observations.

This paper introduces cryoSBI, a method using simulation-based inference to infer biomolecular conformations from cryo-EM images, achieving fast and accurate results.