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CellSpliceNet predicts alternative splicing outcomes in C. elegans neurons by integrating multiple data modalities and achieving high predictive accuracy.

The paper describes five new Caenorhabditis species from Indonesia, reports their phylogenetic placement, and identifies exceptions to Haldane's rule in interspecific hybrid fertility.

The paper identifies trans-regulatory loci influencing gene expression plasticity in Arabidopsis under salicylic acid treatment, showing most loci act in trans and are under-detected in GWAS.

The paper describes a method to achieve targeted sex ratio distortion in mice using a selfish supergene component, resulting in a high prevalence of non-transgenic offspring of the desired sex.

The paper examines the evolution of the NLRP3 inflammasome pathway genes across mammals, revealing chromosomal reorganization and gene duplication events, particularly in Caspase-1 and neighboring genes.

The paper describes a protocol for an in vitro minigene splice assay using the pET01 vector to study aberrant splicing when patient samples or accessible tissues are unavailable.

This study shows that using cryopreserved genetic resources can help manage genetic diversity in animal populations, either by slowing its loss or guiding selection, but requires careful management to avoid issues with old genetic material.

This study investigates the functional impact of pathogenic RHD mutations in Runx2 on skeletal and dental development in a mouse model of cleidocranial dysplasia.

This study shows that the timing of fruit fly death by the fungus Entomophthora muscae is controlled by an endogenous fungal circadian clock, independent of host genetics.

The paper mathematically analyzes bounds on allele-sharing dissimilarity (ASD) statistics, showing how expected ASD values are constrained by allele frequencies, explaining narrow empirical ranges observed in human populations.

This study identifies the genetic interaction between ZmFDL1 and ZmGL15 in maize that modulates cuticle composition and improves drought tolerance by enhancing cutin content and reducing leaf permeability.

Seq2KING uses transformer models to uncover genetic relatedness patterns in humans without predefined labels, revealing continent-based connectivity and population substructures.

MIXPRS improves multi-population polygenic risk score prediction by integrating GWAS summary statistics without individual-level data, outperforming existing methods across multiple traits and populations.

The paper introduces a synthetic CRISPR guide sequence for generating entry strains in C. elegans when the standard dpy-10 guide is unsuitable.

The paper identifies three high-impact mutations in Arabidopsis thaliana that drive DNA methylation variation during colonization of the Cape Verde Islands.

The paper tracks DNA methylation across generations in Arabidopsis lineages to identify a genetic modifier that increases epimutation rates and supports a punctuated-equilibrium model of methylation evolution.

This study links preschool musicality to school-age communication abilities through genetic factors related to rhythmicity using polygenic scores and structural equation modeling.

The paper identifies two HOT regions in the C. elegans dlg-1 gene, showing the upstream region is essential for transcription and development, while the intronic region modestly enhances transcription in epidermal cells.

This paper benchmarks forensic ancestry prediction tools against TabPFN, showing TabPFN outperforms existing methods in accuracy and ROC AUC.

This paper introduces Epi-PHR, a non-disruptive method for single-cell spatial epigenetic profiling, revealing region-specific epigenetic profiles and allele-specific chromatin states.