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No detectable effect of P2 neurons on female post-mating changes in sleep and feeding in Drosophila melanogaster

This study investigates the role of P2 neurons in post-mating behavioral changes in Drosophila melanogaster and finds they are not responsible for altered sleep and food consumption after mating.

Regeneration-associated utrophin expression in skeletal muscle: implications for utrophin-targeted therapies

This study shows that utrophin expression in skeletal muscle is closely tied to regeneration phases and cannot be used alone to assess therapeutic effects, suggesting the need for combined markers.

Sixteen thousand grafts reveal limited scion genetic control of grapevine bench-grafting success

The paper investigates the genetic factors influencing grapevine grafting success using a scion mapping population and identifies a QTL on chromosome 7 associated with increased success.

Unmasking genetic load: Genomic inbreeding drives growth depression in captive critically endangered Chinese Bahaba (Bahaba taipingensis)

The paper investigates genomic inbreeding effects on growth depression in captive Chinese bahaba, identifying genetic factors linked to skeletal and immune pathways.

Point mutations and complex variants impact gene expression and addiction-related behaviors in Heterogeneous Stock rats

The paper identifies non-SNP variants as significant regulators of gene expression and addiction-related traits in HS rats using joint cis-eQTL analysis.

Multi-omic integration using interpretable machine learning reveals genetic mechanisms of trait variation and phenotypic plasticity in switchgrass

This study integrates multi-omic data with interpretable machine learning to identify genetic mechanisms underlying trait variation and phenotypic plasticity in switchgrass across environments.

Synergistic Variants in C-terminal Binding Protein 1 and Alkaline Phosphatase Lead to Mandibular Hypoplasia Through Impaired Wnt Signaling: An Oligogenic Model

The paper identifies synergistic variants in CTBP1 and ALPL causing mandibular hypoplasia through impaired Wnt signaling in a mouse model.

IAP retrotransposons contribute to the transcriptional diversity of the murine placenta

The paper investigates the role of IAP retrotransposons in regulating placental gene expression and transcriptional diversity in mice.

Diversity at the HYP1 locus in potato cyst nematodes does not result from developmentally-programmed somatic mutations

The paper investigates whether diversity at the HYP1 locus in potato cyst nematodes arises from developmental editing or sequencing errors, concluding it is due to evolutionary forces.

Distinct genetic architectures of mRNA expression and splicing QTL in the Diversity Outbred mouse population

The paper maps eQTL, isoQTL, irQTL, and sQTL in DO mice, showing distinct genetic effects on mRNA expression and splicing, and identifies candidate genes and regulatory mechanisms.

QINT, a novel simplified QF/QUAS expression system with integrated temporal expression control

The paper introduces QINT, a temperature-controlled gene expression system that enables temporal regulation of gene expression in Drosophila and other organisms.

Sampling Protein Language Models for Functional Protein Design

This paper evaluates sampling methods for protein language models, showing that multi-mutant strategies outperform single-mutant approaches in capturing epistatic interactions for functional protein design.

Intergenerational instability of the C9orf72 hexanucleotide repeat

The paper investigates intergenerational instability of C9orf72 hexanucleotide repeats, finding increased instability in alleles with >20 repeats and a paternal expansion bias in 20-40 repeat alleles.

Identification of septoria nodorum blotch susceptibility genes in hard winter wheat

The paper identifies susceptibility genes for septoria nodorum blotch in U.S. hard winter wheat using genetic markers and association studies.

Transcription-driven establishment of DNA methylation at the PWS/AS imprinted region

This study shows that transcription across the PWS-SRO is necessary but not sufficient for de novo DNA methylation at the PWS/AS locus, requiring differentiation-dependent cues.

SPLENDID incorporates continuous genetic ancestry in biobank-scale data to improve polygenic risk prediction across diverse populations

SPLENDID improves polygenic risk prediction across diverse populations by incorporating continuous genetic ancestry without requiring discrete ancestry labels.

Telomere length of both parents contributes to heritable POT1 cancer-predisposition syndrome

The paper investigates how POT1 mutations affect telomere inheritance and cancer risk by analyzing telomere length in families with POT1 mutations.

Germline removal reprograms somatic genome maintenance towards faster, energy-efficient, high-fidelity DNA defence and repair

This study shows that removing the germline in zebrafish reprograms somatic DNA repair and stress responses, favoring high-fidelity mechanisms and altering gene expression patterns across multiple organs.

Genome-wide association study of food liking and food preference patterns in young adults

This study conducts a GWAS of food liking in young adults, identifying 16 genome-wide significant associations across 14 traits and one food preference pattern.

A New Disease Gene for Hypokalemic Periodic Paralysis, KCNA7, Established in a Multigenerational Family

The paper identifies a KCNA7 missense variant as a new disease gene for hypokalemic periodic paralysis through genetic, structural, and electrophysiological analyses in a multigenerational family.