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This paper shows that low statistical power in pool-seq GWAS can create the illusion of polygenicity by masking simple genetic architectures through noise.

This study evaluates the long-term viability of wild-type and gene-edited pennycress seeds under different field conditions, finding that gene-edited seeds lose viability faster than wild-type seeds.

The paper constructs a cattle pangenome to identify novel non-reference unique insertions (NRUIs) and links them to economically important traits.

The paper shows that linkage disequilibria from stabilizing selection slow allele-frequency dynamics and provides more accurate predictions than previous formulas.

This study shows that loss of mitochondrial glutathione reductase and thioredoxin reductase in C. elegans causes growth, fertility, and muscle defects, activates a constitutive UPRmt, and alters mitochondrial morphology.

The paper compares skeletal phenotypes between two Down syndrome mouse models, Ts65Dn and Ts66Yah, using a novel PCA-based method to assess the impact of non-Hsa21 trisomic genes on bone structure and function.

The paper identifies genetic and environmental factors influencing multicellular-like phenotypes in fission yeast through experimental and genomic analyses.

The paper identifies tumor-induced factors that reduce brain NPF signaling, leading to low protein appetite and early organ wasting in a fly model of cancer cachexia.

The paper investigates the role of sphingomyelin synthase-1 in C. elegans and finds that its loss does not cause egg retention or locomotion defects, suggesting potential background mutations in the studied mutant.

This paper evaluates primary template-directed amplification (PTA) for whole exome sequencing on small cell samples, showing improved coverage and reduced allelic dropout compared to conventional methods.

This study uses a simulation-based deep learning model to analyze how different parameters affect mosquito suppression and malaria prevalence in Anopheles gambiae.

The paper shows larger eQTL studies detect more signals that colocalize with GWAS signals, improving understanding of gene-trait relationships.

This study evaluates qPCR reporting in top genetics and plant science journals, finding frequent omissions of critical details like RNA integrity, housekeeping gene information, and reagent specifics.

This paper demonstrates that overexpressing Foxp3a in zebrafish induces Treg-mediated immune tolerance, enabling efficient transplantation of gonadal primordia and germline stem cells.

VDJ-Insights annotates IG and TCR loci with high accuracy, identifying novel alleles in human haplotypes.

This study identifies DMT3 as a 6mA demethylase in unicellular eukaryotes and shows its role in maintaining transcriptional and developmental integrity by preventing ectopic 6mA deposition at TSS.

This study reveals fine-scale genetic structure in the Saguenay-Lac-Saint-Jean region using genotype data and genealogies, showing a genetic gradient and historical migration patterns.

This paper investigates the protective effect of the LIG1 K845N variant in Huntington's disease by showing it increases ligase fidelity and suppresses somatic CAG repeat expansion.

The paper compares endogenous small RNAs with synthetic siRNAs using RNA-FM and biological features, finding piRNAs have higher GC content and melting temperature than miRNAs and siRNAs.

The paper examines allelic variation in tRNA genes across three nematode species, finding high mutation rates and purifying selection, with functional mismatches between tRNA anticodons and amino acids.