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This study analyzes genetic diversity and population dynamics of feral horses in the Western US using microsatellite markers, finding variation influenced by management practices and geographic proximity.

The paper shows that highly parameterized polygenic scores overfit to population stratification by including random variants, reducing their generalizability.

The paper shows calcineurin regulates RNAi-mediated transgene silencing and small RNA production in Cryptococcus neoformans through P-body localization and substrate interactions.

The paper identifies and analyzes nonreference sequences in human genomes using long-read sequencing and graph-based pangenome methods, revealing their functional, evolutionary, and phenotypic significance.

This paper presents a digital imaging workflow for standardized, multiplexed quantitative analysis of adult Drosophila eye phenotypes, reducing variability and enabling precise morphometric comparisons.

The paper investigates the evolutionary origins of viral phosphodiesterases (PDEs) that inhibit the OAS-RNase L antiviral pathway, identifying multiple horizontal transfer events and structural divergence patterns.

The paper develops a patient-derived cortical organoid model of UBA5-associated encephalopathy, identifies neurodevelopmental defects, and highlights potential therapeutic strategies.

This study shows that Hippo pathway inactivation reduces cytoophidium length and number in Drosophila posterior follicle cells, linking Hippo signaling to CTPS activity.

This paper generates and characterizes CRISPR-Cas9-mediated XPC gene knockout in human skin cells to model XP-C disease and study its phenotypes and molecular mechanisms.

This study identifies gene expression changes in adolescent rat hippocampus due to prenatal ethanol exposure, highlighting cell adhesion, immune response, and toxin metabolism pathways.

This study identifies dynamic histone lactylation at meiosis-specific sites in mouse spermatogenesis, linking it to gene expression and recombination.

The paper shows that organisms with fewer slightly-deleterious variants are more likely to survive stress, leading to purifying selection on populations.

The paper identifies mutations in Snn1 genes that affect susceptibility to Septoria nodorum blotch and develops markers to eliminate these genes for improved wheat resistance.

The paper identifies a naive piRNA surveillance system that broadly monitors the germline transcriptome for newly invading elements, showing it is abundance-coupled and independent of canonical piRNA pathways.

This study shows that depletion of DNA primases in C. elegans activates the endoplasmic reticulum unfolded protein response (UPR-ER), which is required to alleviate replication stress.

The paper demonstrates that IS110 insertion sequences use a structured RNA to direct sequence-specific DNA recombination, enabling modular genome editing.

The paper develops a multiplex PCR test using COI gene data to identify biting midge species and clades, achieving high sensitivity for Culicoides subgenus Avaritia.

The paper investigates tissue-specific gene expression responses to copper stress in Drosophila melanogaster using differential expression analysis and eQTL mapping across 96 inbred strains.

This paper develops a SNP panel for high-resolution genetic assessment of European bison, enabling accurate genotyping from non-invasive samples and supporting conservation efforts.

This study investigates the function of two ecdysteroid kinase-like genes in Drosophila melanogaster using genetic approaches, finding that they may not directly inactivate ecdysteroids but could have novel roles in development.