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This study develops a probe-independent qPCR method to identify APOL1 variants in kidney transplant recipients and assesses their impact on transplant outcomes.

This study shows that vitamin C increases young LINE-1 element expression in mouse ESCs through H3K9me3 demethylation by KDM4A/C, without increasing somatic insertion rates.

This study identifies ppGpp as a molecule present in Drosophila that regulates sleep and starvation-induced sleep loss through the mesh1 gene and Dilp2 neurons.

This study compares growth retardation in mouse models of Kabuki syndrome 1 and 2, finding similar transcriptional profiles in their chondrocyte models.

This study identifies shared genes between atopic dermatitis and major depression disorder using machine learning and finds SNCA and PARD3 as consistent biomarkers.

This study identifies regional DNA methylation associations with early childhood appetitive traits using epigenome-wide analysis of cord blood samples.

This study uses zebrafish tcn2 knockout to investigate B12's role in embryonic development, finding that B12 supplementation partially rescues developmental defects and alters gene expression in key pathways.

This study identifies biases in proxy GWAS using parental Alzheimer's history, showing misleading genetic correlations and highlighting design issues in biobank cohorts.

The paper identifies KLF4 as a transcriptional regulator of the alternative SHBG promoter in male germ cells through functional analysis of promoter elements.

The paper uses interventional data to infer causal networks for blood traits, revealing regulatory relationships among 788 genes.

The paper uses long-read RNA sequencing to analyze CLN3 transcript complexity in healthy samples, identifying over 100 novel transcripts and 48 ORFs, with the canonical isoform being the most abundant.

This paper introduces molecular time capsules to capture and preserve transcriptomic data from living cells, enabling retrospective analysis of gene expression during cellular transitions.

This study identifies TAF4b's role in regulating transcription during quiescence of mouse prospermatogonia, showing it controls cell cycle genes and has sex-dependent and -independent effects on fertility.

This paper corrects a mouse model of phenylketonuria by transplanting Cypor-deficient hepatocytes selected with acetaminophen, achieving stable normalization of blood phenylalanine levels.

The paper identifies csr-1b as a novel regulator of the Integrator complex involved in snRNA 3' processing through RNAi screens and isoform analysis.

This paper presents a temperature-regulated Cas12a-based gene-drive system and demonstrates double gene drives using Cas9 and Cas12a to spread two engineered alleles.

The paper analyzes 500 whole genomes from 39 Tibeto-Burman populations to uncover genetic differentiation and adaptive features linked to geography and environment.

This paper presents a new high-quality reference genome for South American Plasmodium vivax isolates, showing improved representation compared to existing genomes.

The paper investigates DNA methylation patterns at the mating type locus MRP3 in diatoms, finding that hypomethylation is necessary but not sufficient for MRP3 expression in sexual cells.

The paper identifies male gonad-enriched microRNAs in C. elegans that regulate sperm production and fecundity through functional analysis and small RNA sequencing.