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This paper investigates the role of BRCA1-BARD1 E3 ubiquitin ligase activity in DNA damage repair and meiosis in C. elegans, finding both ligase-dependent and independent functions.

This study identifies genes and pathways that interact with early-life nutrition to influence sleep behavior and brain morphology in Drosophila.

The paper identifies a novel Myc enhancer activated in B cells shortly after activation but finds it is not essential for Myc expression or cell proliferation.

The paper constructs a duck pan-genome and identifies transposon-derived structural variations linked to bodyweight and white plumage traits in ducks.

The paper measures mitotic DNA methylation inheritance at single CpG sites and finds that intermediate methylation is imprecise due to DNMT1 activity, challenging the stability of DNA methylation as an epigenetic mark.

The paper identifies four Neanderthal introgressed alleles on chromosome 3 that may modulate the regulation of CCR1 and CCR5, contributing to severe COVID-19 risk.

This study shows that inactivating the Arp2/3 complex in mouse fibroblasts causes genomic instability, micronuclei formation, and cellular senescence due to mitotic defects.

The paper simulates GWAS in rats to show that larger sample sizes lead to an exponential increase in the number of significant loci detected.

The paper introduces a pangenome analysis pipeline (PSVCP) for rice that improves functional gene identification by capturing structural variations and provides insights into genomic diversity and trait associations.

The paper identifies de novo telomere addition at a hotspot near SUL1 in yeast under sulfate-limiting conditions, stabilizing linear amplicons and contributing to genomic plasticity.

The paper develops statistical methods to estimate variance and covariance of R2 values for polygenic scores, enabling significance testing of predictive ability differences across samples and SNP types.

The paper shows that the attP40 transgenic landing site in Drosophila disrupts Or47b olfactory receptor neuron glomerular organization, suggesting potential genetic interactions or background effects.

The paper estimates transcription fidelity in human cells, identifies factors controlling its accuracy, and links transcription errors to Alzheimer's disease progression.

This study identifies Adr1 as a transcription factor regulating ergosterol pathway and azole resistance in C. albicans, with functional interactions with Upc2.

This paper compares traditional and chatbot-based consent processes for genomics research, finding shorter consent times and positive participant feedback with the chatbot.

This study models toxin-antidote gene drives using Wolbachia's CifA and CifB genes, finding they can create confined drives with varying introduction thresholds and persistence depending on ecological factors.

This paper shows that f-statistics can be biased when using non-outgroup SNP ascertainment schemes and proposes a pan-African ascertainment approach to reduce bias in population history inference.

This study identifies and functionally characterizes IsAQP1, an aquaporin in Ixodes scapularis, showing it is a water channel with low glycerol permeability and salivary gland-specific expression.

This paper introduces a Bayesian framework to infer temporally variable selection from ancient DNA data by modeling genotype likelihoods and sample uncertainties, demonstrating improved selection inference using ancient horse coat color loci.

This paper describes the optimization of base editing to correct the SMN2 exon 7 mutation in SMA, achieving high editing efficiency and increased SMN protein levels in vitro and in vivo.