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The paper examines non-redundant roles of paralogous proteins in yeast glucose-sensing pathways through gene deletion and multi-omics analyses.

This study identifies QTLs for internode length and diameter linked to lodging resistance in rice using a recombinant inbred line population and RNA-Seq analysis.

This study evaluates how rescaling population genetic simulations affects evolutionary dynamics in Drosophila-like populations, finding biases in summary statistics under certain conditions.

The paper identifies 490 genes involved in beetle defensive stink gland function using RNAi screening and transcriptomics, highlighting Laccase2 as the phenoloxidase responsible for toxic para-benzoquinone synthesis.

The paper evaluates the transportability of in-vitro gene perturbation models to in-vivo human phenotypes using CRISPR data and UK Biobank, finding some models are predictive while others are not.

This study evaluates strategies to improve homing gene drive efficiency using multiplexed gRNAs, finding that population-level multiplexing enhances drive efficiency despite increased vulnerability to resistance.

This study identifies LIPL-1 and LIPL-2 as TCER-1-regulated lysosomal lipases with distinct roles in balancing immunity and fertility in C. elegans.

This paper identifies GulpR, a Drosophila GPCR expressed in enteroendocrine cells, and shows it regulates Tachykinin transcription, essential for lipid mobilization during nutrient limitation but not infection.

This study identifies VILMIR as a long noncoding RNA that enhances the host interferon response by interacting with transcriptional and translational regulators in human epithelial cells.

The paper identifies novel microRNA regulators of stem cell function in Drosophila adult intestine through profiling and functional validation of miR-31a and miR-34.

This study investigates the role of m6A RNA methylation in X-chromosome inactivation and X to autosome dosage compensation in early embryonic lineages, finding that m6A depletion has a minor effect on dosage compensation.

This study maps single-cell eQTLs in lung tissue, revealing cell-type-specific genetic regulation and linking it to lung cancer susceptibility.

The paper introduces ARG-RHE, a method to estimate heritability and perform association testing using ancestral recombination graphs, showing improved results over imputation alone.

The paper investigates how different dietary macronutrient conditions affect insulin-like peptide expression and developmental outcomes in Drosophila.

Airqtl accelerates single-cell eQTL mapping and enables cell state-specific causal gene regulatory network inference using efficient linear mixed models.

The paper investigates the phenotypic effects of archaic protein-altering variants in living humans using UK Biobank data, finding no significant differences in health or cognitive traits among carriers.

The paper finds that higher serum theobromine levels are associated with slower epigenetic ageing in humans, as measured by GrimAge and DNAmTL.

The paper analyzes the distribution of simple repeat lengths across mammalian genomes and shows that long repeats are abundant due to mutational dynamics, not natural selection.

The paper describes the development of a congenic C57BL/6 rd1 mouse model to improve retinal degeneration research by reducing genetic variability.