Discover, rate, and discuss biology preprints.

The paper examines colocalization and discordance between plasma and brain cis-pQTLs, finding that most colocalize but some show opposite genetic effects, with implications for interpreting protein-trait associations.

This study uses temporal allele frequency changes to detect adaptive variants in winter wheat breeding programs, finding that selection signals identify non-neutral variants associated with grain yield and protein content.

The paper generates a genetically diverse panel of iPSCs from a mouse population and identifies regulatory loci influencing gene expression variation.

This study links the schizophrenia risk gene znf804a to circadian behaviors in zebrafish by showing altered gene expression and transcript processing in mutants.

MCNV2 assesses CNV quality using Mendelian Precision, offering tools to compute, explore, and optimize CNV call accuracy in parent-offspring trios.

The paper develops a chimeric human-mouse lung vascular model using hiPSCs to study BMPR2-related pulmonary hypertension, revealing novel molecular and functional defects in human endothelial cells.

The paper introduces a genomic prediction model that forecasts yield performance across environments and future climates and identifies adapted maize landraces by integrating genomic offset and gene diversity.

ExTaSy enables flexible endogenous gene tagging in Drosophila by swapping 3XHA tags via crosses and provides software for guide RNA design.

The paper quantifies genomic differences between lab-cultivated lineages of C. elegans isolates, finding SNP and indel enrichment in introns and SV enrichment in intergenic regions.

The paper investigates how human transcription factors bind specific DNA sites in yeast, finding that disordered regions influence binding selectivity beyond DNA motifs.

The paper fine-maps PD GWAS signals across cell types, revealing convergent glial-neuronal risk genes and a shared vesiculopathy network.

This paper shows how transposable elements facilitated the de novo origin and diversification of antifreeze protein genes in snailfishes through regulatory sequence recruitment and locus expansion.

The paper reports whole-genome sequencing of a mid-20th-century femur from Israel, revealing Arab ancestry instead of the proposed Ashkenazi Jewish origin.

The paper investigates how evolutionary origins and chromatin states influence X-chromosome upregulation patterns in eutherian and metatherian embryogenesis.

This study uses CRISPR activation to upregulate PIKFYVE in Fig4 deficient mice, showing that a 2-fold increase is insufficient to rescue lysosomal enlargement and survival.

This study finds that men exposed to trauma have elevated sperm miRNAs linked to anxiety and depression in offspring, though not all trauma-exposed men show increased anxiety or depression themselves.

This paper identifies 18 novel X chromosome loci associated with dietary intake traits using multiple X-WAS models in the UK Biobank.

This study shows that replication-associated single-stranded DNA increases formaldehyde-induced mutagenesis through specific repair pathways.

The paper uses a modified MPRA to assess CYP3A4 enhancer variants with their native promoter, identifying variants with significant regulatory impact on drug response and cancer severity.

SNPic uses topic modeling to cluster complex phenotypes by interpreting GWAS data as a corpus, identifying interpretable genetic modules and biological mechanisms.