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This paper introduces a mathematical framework to classify, quantify, and compare genetic buffering relationships between genes using a ratio scale and a novel 'parallel' model.

The paper generates two novel D2hgdh loss-of-function mutations in Drosophila to study D-2HG accumulation and its effects on development and metabolism.

The paper identifies PALS-22 as a regulator of AGO expression in C. elegans, showing its role in balancing immunity and germline health through modulation of RNAi and epigenetic inheritance.

The paper introduces diplo-locus, a Python toolkit for simulating and inferring parameters from time-series genetic data under diploid selection models.

The paper develops a framework to estimate genetic and social homogamy using family data and finds that indirect assortative mating better explains educational attainment similarities than direct assortment.

This study compares phase-free and phase-based local ancestry inference methods, finding phase-free methods provide more accurate results despite lower phase quality.

This study examines epigenetic changes in Borrelia-infected ticks, finding increased EHMT2 expression but no change in DNA methylation of specific repeats.

This study identifies transposon activities as key drivers of sweet orange cultivar selection and diversification over the last 500 years.

The paper describes a high-efficiency method for homology-dependent genome editing in Cryptococcus neoformans using CRISPR/Cas9 and a Ku80 mutant strain.

This paper investigates how geographic breadth of sampling affects the discovery and frequency of rare, deleterious variants in genetic studies.

This study identifies diencephalic and neuropeptidergic dysfunction in zebrafish with autism-risk mutations, revealing potential molecular and behavioral mechanisms.

The paper applies the MR-Horse method to reduce selection bias in GWAS of disease progression by accounting for genetic correlation and pleiotropy, showing reduced bias and controlled type 1 error rates.

The paper identifies a 5 kb deletion causing Sex-linked orange coat color in cats by ectopic Arhgap36 expression, which inhibits PKA and disrupts melanogenic pathways downstream of Mc1r.

The paper presents an algorithm to calculate the expected Site Frequency Spectrum (SFS) in structured populations, enabling demographic parameter inference in the symmetrical n-island model.

The paper investigates the physiological role and mechanisms of a noncoding haplotype associated with blood pressure by combining animal models, genome editing, and chromatin analysis.

The paper introduces Variant-FlowFISH to measure the effects of DNA sequence variants on gene expression, identifies regulatory mechanisms, and benchmarks predictive models.

clusIBD detects IBD segments from poor-quality DNA samples with high genotype errors, outperforming existing tools in simulated and ancient DNA data.

This study identifies genetic loci associated with seed protein composition in pea using GWAS and QTL mapping, revealing overlapping regions and candidate genes involved in protein biosynthesis and modification.

The paper introduces a new inverse probability of selection weighted Cox model to correct for outcome-dependent sampling bias in survival analysis, demonstrating its effectiveness through simulations and real datasets.

The paper identifies genetic loci associated with saline self-administration in mice, finding distinct genetic bases compared to cocaine self-administration.