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The paper shows that boosting TCA cycle activity through nutritional strategies improves neonatal host defense against infection by enhancing disease tolerance and resistance.

The paper profiles HLA immunopeptidomes and interactomes in microglia, identifying disease-associated epitopes and their interactions.

This study uses single-cell and spatial transcriptomics to analyze granuloma formation in a natural CGD mouse model and identifies therapeutic targets.

This study shows that antibiotic-induced microbiome modulation in mice alters immune responses to gluten, increasing duodenal eosinophils and activating epithelial γδ T-cells.

This paper develops an in vitro model of SIV latency in rhesus macaque CD4+ T cells, generating latently infected cells that mimic in vivo reservoirs and enabling studies of latency mechanisms and cure strategies.

This study identifies how IL-10 suppresses inflammatory gene expression by targeting IRF transcription factors and altering chromatin accessibility and histone marks in human monocytes.

This study shows that type 1 immunity, via IFNγ signaling, protects intestinal tissue from damage during helminth infection without reducing parasite burden.

This study identifies JAK inhibitor-selective epigenetic regulation of IFN-γ signature genes in macrophages from RA and COVID-19 patients, revealing therapeutic insights and risks.

This study shows that influenza virus infection causes reduced immune cell counts and impaired differentiation in the thymus and bone marrow, linked to systemic inflammation and oxidative stress.

This study identifies RBM39 as a regulator of innate immunity by controlling transcription and splicing of key interferon response factors, revealing its potential as a therapeutic target.

The paper expands hematopoietic progenitors to study T cell development, identifying key regulators that control progression.

The paper develops fluorescence-barcoded cell lines expressing membrane-anchored influenza neuraminidases to study antibody responses and vaccine efficacy.

This paper shows that an mRNA vaccine encoding the CCHFV nucleocapsid protein provides 100% protection against lethal viral challenge in mice.

TRAIT compiles nearly 8 million experimentally validated TCR-antigen pairs to provide a comprehensive resource for T-cell receptor interactions, aiding immunotherapy and vaccine design.

This study identifies phosphoethanolamine as a key metabolite in tumor interstitial fluid that suppresses T cell function by inhibiting TCR signaling.

This study identifies mitochondrial hyperactivity and reactive oxygen species as critical drivers of innate immunity to the YFV-17D vaccine, enhancing IFN response and vaccine effectiveness.

The paper identifies shared proliferation acceleration and heterogeneous transcriptional changes during B-lymphoid and neutrophil/monocyte lineage restriction from CD34+ cord blood cells.