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This study shows that co-delivering PD-L1 with AAV-delivered bNAb 10-1074 reduces ADA responses and improves bNAb durability in rhesus macaques.

This study identifies redundant γc cytokines that enhance IL-1-driven neutrophil inflammation via MEK/ERK convergence, showing that blocking the shared γc receptor or MEK/ERK reduces disease severity.

This study identifies age-related defects in CXCL13+ T follicular helper cells in human tonsil organoids, linking them to reduced antibody responses.

This study shows that entinostat enhances CD8+ T cell responses in tumors but only when administered during a specific window after T cell activation, and this effect can be restored by prior oncolytic virus treatment.

The paper shows that human IgE+ plasma cells are selectively killed by BCR crosslinking due to a JNK/PTEN/BIM signaling axis, distinct from mouse mechanisms, and highlights therapeutic implications for anti-IgE antibodies.

This study shows that CSF1R-dependent macrophages are essential for hematopoiesis but many functions of tissue resident macrophages are redundant or strain-specific in mice.

This study demonstrates that Coated Bacterial Vaccines (CBVs) enhance the immunogenicity of a GnRH-based peptide vaccine, inducing a strong Th2-biased humoral response and effective immunocastration in mice.

The paper identifies lipid mediator networks associated with COVID-19 severity and risk of critical illness using multi-omics profiling across disease severity groups.

This study develops a spectral flow cytometry approach to identify macrophage subpopulations in healthy and MASH livers, revealing distinct autofluorescence signatures and highlighting the importance of accurate AF correction.

This study characterizes nano- and microplastics in pediatric tonsils and shows they trigger transient immunomodulatory responses in lymphoid organoids.

A CRISPRi screen identifies SON and MAP4K1 as regulators of IL-22 and IL-17 expression in innate lymphoid cells, revealing new therapeutic targets for immune-mediated diseases.

This study shows that anti-MDA5 autoantibodies and MDA5 form a complex that promotes fibroblast proliferation and pro-fibrotic responses in lung fibroblasts, contributing to interstitial lung disease.

This study compares IL-33-induced proteomic responses across different mast cell types and identifies p38 MAPK as a key regulator of the inflammatory programme.

This study identifies SCD as a lipid metabolic checkpoint that regulates macrophage activation and plasticity by maintaining lipid desaturation balance and preventing pro-inflammatory responses.

This study uses EGFP-talin1 knock-in mice to show talin-1 dynamics during neutrophil migration in vivo, revealing its polarization during directional movement.

This study evaluates an intratumoral B7H3:CD3 TCE in canine sarcoma patients, showing localized T-cell accumulation without systemic toxicity.

This study shows that macrophages alter cytokine responses and bacterial spatial organization in airway epithelial cultures without changing bacterial burden.

This study shows that vaccination of macaques with an Env-ferritin nanoparticle rapidly elicits V2-apex broadly neutralizing antibodies with immunogenetic features that may be applicable to humans.