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This study investigates the biodistribution and effects of Ronapreve in a mouse model of SARS-CoV-2 infection, showing it does not reach the brain but reduces viral loads in the lung and brain.

The paper develops a deep learning tool to analyze endometrial histology and identifies morphological correlates of miscarriage risk.

The paper investigates the association between Alzheimer's disease and Biondi body amyloid in hippocampal-associated choroid plexus epithelial cells and ependymal cells, finding a near-significant increase in BB-containing CPECs and a significant increase in BB-like amyloid in ependymal cells in AD.

COLOR-3D improves 3D histology by enhancing dye penetration and enables quantitative analysis of tissue morphology and aging-related changes in mouse liver.

This study identifies age and adiposity-related lipid droplet accumulation in human choroid plexus epithelial cells, with associations with BMI, sex, and Alzheimer's Disease.

This study shows hepatocyte TEAD1 promotes fibrosis and inflammation in cholestatic liver injury but not bile acid metabolism, suggesting it as a therapeutic target in PSC.

This study generates two mouse models of nephronophthisis by inactivating Nphp3 at different developmental stages, revealing distinct disease mechanisms and treatment responses.

This paper develops an interpretable AI framework for leukocyte morphology classification in peripheral blood smears, achieving high accuracy with reduced annotation needs and providing clinical tools for integration.

This paper develops a registration pipeline to align multimodal 3D imaging data from colon cancer tissue and uses unsupervised clustering to identify spatially coherent tissue regions.

This study observes specific patho-phenotypes in tomato leaves infiltrated with Ralstonia pseudosolanacearum, including petiole bending, epinasty, and senescence, which are hrp-dependent and not seen with other bacteria.

This study characterizes the genotypic and functional differences between healthy and pressure sore-derived fibroblasts, revealing reduced ECM protein expression and impaired myofibroblast differentiation.

The paper identifies BRRF1 as a key driver of transcriptome-wide splicing defects during gammaherpesvirus reactivation by hijacking the CCR4-NOT complex.

The paper quantifies placental pathology and maternal perfusion in healthy primate pregnancies, revealing associations between stromal mineralization and reduced perfusion, and identifying key pathologies linked to vascular malperfusion.

DigitAb predicts cell types from H&E-stained slides using deep learning, achieving high accuracy without specialized assays or immunostains.

This study develops a dual-action nanoconjugate combining r-tPA and DNase to target r-tPA-resistant clots, showing improved reperfusion and reduced lesion volume in an ischemic stroke model.

The paper investigates how hydraulic fracturing in aortic dissection causes medial damage beyond the false lumen, leading to structural weakening of the aortic wall.

This study develops a murine model of slow-progressing knee osteoarthritis by inducing non-invasive posterior cruciate ligament rupture and compares its progression to the destabilized medial meniscus model.

This study shows that Huntington disease in mice causes early embryonic changes in neocortical patterning, leading to postnatal sensorimotor deficits.